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Death receptor-induced cell killing.
Thorburn A. Thorburn A. Cell Signal. 2004 Feb;16(2):139-44. doi: 10.1016/j.cellsig.2003.08.007. Cell Signal. 2004. PMID: 14636884 Review.
An apoptosis signaling pathway induced by the death domain of FADD selectively kills normal but not cancerous prostate epithelial cells.
Morgan MJ, Thorburn J, Thomas L, Maxwell T, Brothman AR, Thorburn A. Morgan MJ, et al. Cell Death Differ. 2001 Jul;8(7):696-705. doi: 10.1038/sj.cdd.4400866. Cell Death Differ. 2001. PMID: 11464214
FADD-DN induces caspase activation in normal epithelial cells as demonstrated using a Fluorescence Resonance Energy Transfer assay that measures caspase activity in individual living cells. ...Therefore, the death domain of FADD has a previously unrecognized role in …
FADD-DN induces caspase activation in normal epithelial cells as demonstrated using a Fluorescence Resonance Energy Transfer assay th …
Recruitment of TRADD, FADD, and caspase 8 to double-stranded RNA-triggered death inducing signaling complexes (dsRNA-DISCs).
Iordanov MS, Kirsch JD, Ryabinina OP, Wong J, Spitz PN, Korcheva VB, Thorburn A, Magun BE. Iordanov MS, et al. Apoptosis. 2005 Jan;10(1):167-76. doi: 10.1007/s10495-005-6071-x. Apoptosis. 2005. PMID: 15711932
Double-stranded RNA (dsRNA), a viral product, is potently and rapidly apoptogenic in susceptible cells. Caspase 8 plays an important role in the dsRNA-induced apoptosis; however, the mechanisms of caspase 8 activation in response to dsRNA are unknown. ...
Double-stranded RNA (dsRNA), a viral product, is potently and rapidly apoptogenic in susceptible cells. Caspase 8 plays an important …
BCL-2 family inhibitors enhance histone deacetylase inhibitor and sorafenib lethality via autophagy and overcome blockade of the extrinsic pathway to facilitate killing.
Martin AP, Park MA, Mitchell C, Walker T, Rahmani M, Thorburn A, Häussinger D, Reinehr R, Grant S, Dent P. Martin AP, et al. Mol Pharmacol. 2009 Aug;76(2):327-41. doi: 10.1124/mol.109.056309. Epub 2009 May 29. Mol Pharmacol. 2009. PMID: 19483105 Free PMC article.
The lethality of sorafenib was enhanced in pancreatic tumor cells in a synergistic fashion by pharmacologically achievable concentrations of the HDACIs vorinostat or sodium valproate. ...Sorafenib + HDACI exposure generated a CD95- and Beclin1-dependent protective f …
The lethality of sorafenib was enhanced in pancreatic tumor cells in a synergistic fashion by pharmacologically achievable concentrat …
The Autophagy Machinery Controls Cell Death Switching between Apoptosis and Necroptosis.
Goodall ML, Fitzwalter BE, Zahedi S, Wu M, Rodriguez D, Mulcahy-Levy JM, Green DR, Morgan M, Cramer SD, Thorburn A. Goodall ML, et al. Dev Cell. 2016 May 23;37(4):337-349. doi: 10.1016/j.devcel.2016.04.018. Dev Cell. 2016. PMID: 27219062 Free PMC article.
MAP3K7 is a tumor suppressor gene associated with poor disease-free survival in prostate cancer. Here, we report that Map3k7 deletion in mouse prostate cells sensitizes to cell death by TRAIL (TNF-related apoptosis-inducing ligand). ...These data show that the autophagy ma …
MAP3K7 is a tumor suppressor gene associated with poor disease-free survival in prostate cancer. Here, we report that Map3k7 deletion …
TRAIL receptor signaling regulation of chemosensitivity in vivo but not in vitro.
Menke C, Goncharov T, Qamar L, Korch C, Ford HL, Behbakht K, Thorburn A. Menke C, et al. PLoS One. 2011 Jan 14;6(1):e14527. doi: 10.1371/journal.pone.0014527. PLoS One. 2011. PMID: 21264287 Free PMC article.
However, selective inhibition of TRAIL receptor signaling caused reduced tumor regression and clearance in vivo when tested in a NOD/SCID mouse model. ...
However, selective inhibition of TRAIL receptor signaling caused reduced tumor regression and clearance in vivo when tested in a NOD/ …
EGFR-targeted diphtheria toxin stimulates TRAIL killing of glioblastoma cells by depleting anti-apoptotic proteins.
Horita H, Thorburn J, Frankel AE, Thorburn A. Horita H, et al. J Neurooncol. 2009 Nov;95(2):175-184. doi: 10.1007/s11060-009-9914-4. Epub 2009 May 17. J Neurooncol. 2009. PMID: 19449148 Free PMC article.
DT-EGF kills GBM cells by a non apoptotic mechanism whereas TRAIL kills by inducing apoptosis. GBM cells treated with DT-EGF and TRAIL were killed in a synergistic fashion in vitro and the combination was more effective than either treatment alone in vivo. ...These …
DT-EGF kills GBM cells by a non apoptotic mechanism whereas TRAIL kills by inducing apoptosis. GBM cells treated with DT-EGF and TRAI …
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) pathway signaling.
Thorburn A. Thorburn A. J Thorac Oncol. 2007 Jun;2(6):461-5. doi: 10.1097/JTO.0b013e31805fea64. J Thorac Oncol. 2007. PMID: 17545839 Review.
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)/Apo1L is a death ligand, a cytokine that activates apoptosis through cell surface death receptors. ...
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)/Apo1L is a death ligand, a cytokine that activates apoptosis t …
Fatty acid synthase: a novel target for antiglioma therapy.
Zhao W, Kridel S, Thorburn A, Kooshki M, Little J, Hebbar S, Robbins M. Zhao W, et al. Br J Cancer. 2006 Oct 9;95(7):869-78. doi: 10.1038/sj.bjc.6603350. Epub 2006 Sep 12. Br J Cancer. 2006. PMID: 16969344 Free PMC article.
Cell cycle analysis demonstrated a time- and dose-dependent increase in S-phase cell arrest following cerulenin treatment for 24 h. ...These findings suggest that FAS might be a novel target for antiglioma therapy....
Cell cycle analysis demonstrated a time- and dose-dependent increase in S-phase cell arrest following cerulenin treatment for 24 h. . …
Induction of apoptosis by tumor cell-targeted toxins.
Thorburn A, Thorburn J, Frankel AE. Thorburn A, et al. Apoptosis. 2004 Jan;9(1):19-25. doi: 10.1023/B:APPT.0000012118.95548.88. Apoptosis. 2004. PMID: 14739595 Review.
Targeted toxins are fusion proteins that combine a targeting molecule that selectively binds to and enters tumor cells with a protein toxin that kills the target cells. These molecules represent an exciting approach to develop effective cancer-specific therapeutics …
Targeted toxins are fusion proteins that combine a targeting molecule that selectively binds to and enters tumor cells with a
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