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AMPK and p53 help cells through lean times.
Thoreen CC, Sabatini DM. Thoreen CC, et al. Cell Metab. 2005 May;1(5):287-8. doi: 10.1016/j.cmet.2005.04.009. Cell Metab. 2005. PMID: 16054073 Review.
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1.
Sancak Y, Peterson TR, Shaul YD, Lindquist RA, Thoreen CC, Bar-Peled L, Sabatini DM. Sancak Y, et al. Among authors: thoreen cc. Science. 2008 Jun 13;320(5882):1496-501. doi: 10.1126/science.1157535. Epub 2008 May 22. Science. 2008. PMID: 18497260 Free PMC article.
Rapamycin inhibits mTORC1, but not completely.
Thoreen CC, Sabatini DM. Thoreen CC, et al. Autophagy. 2009 Jul;5(5):725-6. doi: 10.4161/auto.5.5.8504. Epub 2009 Jul 22. Autophagy. 2009. PMID: 19395872
Discovery of 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancer.
Liu Q, Chang JW, Wang J, Kang SA, Thoreen CC, Markhard A, Hur W, Zhang J, Sim T, Sabatini DM, Gray NS. Liu Q, et al. Among authors: thoreen cc. J Med Chem. 2010 Oct 14;53(19):7146-55. doi: 10.1021/jm101144f. J Med Chem. 2010. PMID: 20860370 Free PMC article.
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