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Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α.
Thorne CA, Hanson AJ, Schneider J, Tahinci E, Orton D, Cselenyi CS, Jernigan KK, Meyers KC, Hang BI, Waterson AG, Kim K, Melancon B, Ghidu VP, Sulikowski GA, LaFleur B, Salic A, Lee LA, Miller DM 3rd, Lee E. Thorne CA, et al. Nat Chem Biol. 2010 Nov;6(11):829-36. doi: 10.1038/nchembio.453. Epub 2010 Oct 3. Nat Chem Biol. 2010. PMID: 20890287 Free PMC article.
A biochemical screen for identification of small-molecule regulators of the Wnt pathway using Xenopus egg extracts.
Thorne CA, Lafleur B, Lewis M, Hanson AJ, Jernigan KK, Weaver DC, Huppert KA, Chen TW, Wichaidit C, Cselenyi CS, Tahinci E, Meyers KC, Waskow E, Orton D, Salic A, Lee LA, Robbins DJ, Huppert SS, Lee E. Thorne CA, et al. J Biomol Screen. 2011 Oct;16(9):995-1006. doi: 10.1177/1087057111416657. Epub 2011 Aug 21. J Biomol Screen. 2011. PMID: 21859680 Free PMC article.
Generation and Quantitative Imaging of Enteroid Monolayers.
Sanman LE, Chen IW, Bieber JM, Thorne CA, Wu LF, Altschuler SJ. Sanman LE, et al. Among authors: thorne ca. Methods Mol Biol. 2020;2171:99-113. doi: 10.1007/978-1-0716-0747-3_6. Methods Mol Biol. 2020. PMID: 32705637
A Kinase Divided.
Karra AS, Taylor CA 4th, Thorne CA, Cobb MH. Karra AS, et al. Among authors: thorne ca. Cancer Cell. 2015 Aug 10;28(2):145-7. doi: 10.1016/j.ccell.2015.07.008. Cancer Cell. 2015. PMID: 26267529 Free article.
Feedback in the β-catenin destruction complex imparts bistability and cellular memory.
Cantoria MJ, Alizadeh E, Ravi J, Varghese RP, Bunnag N, Pond KW, Kettenbach AN, Ahmed Y, Paek AL, Tyson JJ, Doubrovinski K, Lee E, Thorne CA. Cantoria MJ, et al. Among authors: thorne ca. Proc Natl Acad Sci U S A. 2023 Jan 10;120(2):e2208787120. doi: 10.1073/pnas.2208787120. Epub 2023 Jan 4. Proc Natl Acad Sci U S A. 2023. PMID: 36598937 Free PMC article.
43 results