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28 results
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Protein kinase C beta is dispensable for TCR-signaling.
Thuille N, Gruber T, Böck G, Leitges M, Baier G. Thuille N, et al. Mol Immunol. 2004 Jun;41(4):385-90. doi: 10.1016/j.molimm.2004.03.007. Mol Immunol. 2004. PMID: 15163535
Protein kinase Cepsilon is dispensable for TCR/CD3-signaling.
Gruber T, Thuille N, Hermann-Kleiter N, Leitges M, Baier G. Gruber T, et al. Among authors: thuille n. Mol Immunol. 2005 Feb;42(3):305-10. doi: 10.1016/j.molimm.2004.07.007. Mol Immunol. 2005. PMID: 15589318
Critical role of novel Thr-219 autophosphorylation for the cellular function of PKCtheta in T lymphocytes.
Thuille N, Heit I, Fresser F, Krumböck N, Bauer B, Leuthaeusser S, Dammeier S, Graham C, Copeland TD, Shaw S, Baier G. Thuille N, et al. EMBO J. 2005 Nov 16;24(22):3869-80. doi: 10.1038/sj.emboj.7600856. Epub 2005 Oct 27. EMBO J. 2005. PMID: 16252004 Free PMC article.
PKCtheta and PKA are antagonistic partners in the NF-AT transactivation pathway of primary mouse CD3+ T lymphocytes.
Hermann-Kleiter N, Thuille N, Pfeifhofer C, Gruber T, Schäfer M, Zitt C, Hatzelmann A, Schudt C, Leitges M, Baier G. Hermann-Kleiter N, et al. Among authors: thuille n. Blood. 2006 Jun 15;107(12):4841-8. doi: 10.1182/blood-2005-10-4044. Epub 2006 Mar 2. Blood. 2006. PMID: 16514061
Comment on "PDK1 nucleates T cell receptor-induced signaling complex for NF-kappaB activation".
Gruber T, Freeley M, Thuille N, Heit I, Shaw S, Long A, Baier G. Gruber T, et al. Among authors: thuille n. Science. 2006 Apr 7;312(5770):55; author reply 55. doi: 10.1126/science.1122000. Science. 2006. PMID: 16601177
Defective IgG2a/2b class switching in PKC alpha-/- mice.
Pfeifhofer C, Gruber T, Letschka T, Thuille N, Lutz-Nicoladoni C, Hermann-Kleiter N, Braun U, Leitges M, Baier G. Pfeifhofer C, et al. Among authors: thuille n. J Immunol. 2006 May 15;176(10):6004-11. doi: 10.4049/jimmunol.176.10.6004. J Immunol. 2006. PMID: 16670309
The nuclear orphan receptor NR2F6 suppresses lymphocyte activation and T helper 17-dependent autoimmunity.
Hermann-Kleiter N, Gruber T, Lutz-Nicoladoni C, Thuille N, Fresser F, Labi V, Schiefermeier N, Warnecke M, Huber L, Villunger A, Eichele G, Kaminski S, Baier G. Hermann-Kleiter N, et al. Among authors: thuille n. Immunity. 2008 Aug 15;29(2):205-16. doi: 10.1016/j.immuni.2008.06.008. Immunity. 2008. PMID: 18701084 Free PMC article.
PKC theta cooperates with PKC alpha in alloimmune responses of T cells in vivo.
Gruber T, Hermann-Kleiter N, Pfeifhofer-Obermair C, Lutz-Nicoladoni C, Thuille N, Letschka T, Barsig J, Baudler M, Li J, Metzler B, Nüsslein-Hildesheim B, Wagner J, Leitges M, Baier G. Gruber T, et al. Among authors: thuille n. Mol Immunol. 2009 Jun;46(10):2071-9. doi: 10.1016/j.molimm.2009.02.030. Epub 2009 Apr 7. Mol Immunol. 2009. PMID: 19356803
The potent protein kinase C-selective inhibitor AEB071 (sotrastaurin) represents a new class of immunosuppressive agents affecting early T-cell activation.
Evenou JP, Wagner J, Zenke G, Brinkmann V, Wagner K, Kovarik J, Welzenbach KA, Weitz-Schmidt G, Guntermann C, Towbin H, Cottens S, Kaminski S, Letschka T, Lutz-Nicoladoni C, Gruber T, Hermann-Kleiter N, Thuille N, Baier G. Evenou JP, et al. Among authors: thuille n. J Pharmacol Exp Ther. 2009 Sep;330(3):792-801. doi: 10.1124/jpet.109.153205. Epub 2009 Jun 2. J Pharmacol Exp Ther. 2009. PMID: 19491325
PKCtheta and Itk functionally interact during primary mouse CD3+ T cell activation.
Thuille N, Lutz-Nicoladoni C, Letschka T, Hermann-Kleiter N, Heit I, Baier G. Thuille N, et al. Immunol Lett. 2009 Sep 22;126(1-2):54-9. doi: 10.1016/j.imlet.2009.07.014. Epub 2009 Aug 12. Immunol Lett. 2009. PMID: 19682494
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