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Interindividual variability of CYP2C19-catalyzed drug metabolism due to differences in gene diplotypes and cytochrome P450 oxidoreductase content.
Shirasaka Y, Chaudhry AS, McDonald M, Prasad B, Wong T, Calamia JC, Fohner A, Thornton TA, Isoherranen N, Unadkat JD, Rettie AE, Schuetz EG, Thummel KE. Shirasaka Y, et al. Among authors: thummel ke. Pharmacogenomics J. 2016 Aug;16(4):375-87. doi: 10.1038/tpj.2015.58. Epub 2015 Sep 1. Pharmacogenomics J. 2016. PMID: 26323597 Free PMC article.
Can oral midazolam predict oral cyclosporine disposition?
Paine MF, Davis CL, Shen DD, Marsh CL, Raisys VA, Thummel KE. Paine MF, et al. Among authors: thummel ke. Eur J Pharm Sci. 2000 Nov;12(1):51-62. doi: 10.1016/s0928-0987(00)00139-1. Eur J Pharm Sci. 2000. PMID: 11121733
Effects of pregnancy on CYP3A and P-glycoprotein activities as measured by disposition of midazolam and digoxin: a University of Washington specialized center of research study.
Hebert MF, Easterling TR, Kirby B, Carr DB, Buchanan ML, Rutherford T, Thummel KE, Fishbein DP, Unadkat JD. Hebert MF, et al. Among authors: thummel ke. Clin Pharmacol Ther. 2008 Aug;84(2):248-53. doi: 10.1038/clpt.2008.1. Epub 2008 Feb 20. Clin Pharmacol Ther. 2008. PMID: 18288078 Clinical Trial.
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