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In vitro and in vivo drug interactions involving human CYP3A.

Thummel KE, Wilkinson GR. Thummel KE, et al. Annu Rev Pharmacol Toxicol. 1998;38:389-430. doi: 10.1146/annurev.pharmtox.38.1.389. Annu Rev Pharmacol Toxicol. 1998. PMID: 9597161 Review.

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Interindividual variability of CYP2C19-catalyzed drug metabolism due to differences in gene diplotypes and cytochrome P450 oxidoreductase content.

Shirasaka Y, Chaudhry AS, McDonald M, Prasad B, Wong T, Calamia JC, Fohner A, Thornton TA, Isoherranen N, Unadkat JD, Rettie AE, Schuetz EG, Thummel KE. Shirasaka Y, et al. Among authors: thummel ke. Pharmacogenomics J. 2016 Aug;16(4):375-87. doi: 10.1038/tpj.2015.58. Epub 2015 Sep 1. Pharmacogenomics J. 2016. PMID: 26323597 Free PMC article.

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Genetic risk factors for major bleeding in patients treated with warfarin in a community setting.

Roth JA, Boudreau D, Fujii MM, Farin FM, Rettie AE, Thummel KE, Veenstra DL. Roth JA, et al. Among authors: thummel ke. Clin Pharmacol Ther. 2014 Jun;95(6):636-43. doi: 10.1038/clpt.2014.26. Epub 2014 Feb 6. Clin Pharmacol Ther. 2014. PMID: 24503627 Free PMC article.

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Measurement and compartmental modeling of the effect of CYP3A5 gene variation on systemic and intrarenal tacrolimus disposition.

Zheng S, Tasnif Y, Hebert MF, Davis CL, Shitara Y, Calamia JC, Lin YS, Shen DD, Thummel KE. Zheng S, et al. Among authors: thummel ke. Clin Pharmacol Ther. 2012 Dec;92(6):737-45. doi: 10.1038/clpt.2012.175. Epub 2012 Oct 17. Clin Pharmacol Ther. 2012. PMID: 23073208 Free PMC article.

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Can oral midazolam predict oral cyclosporine disposition?

Paine MF, Davis CL, Shen DD, Marsh CL, Raisys VA, Thummel KE. Paine MF, et al. Among authors: thummel ke. Eur J Pharm Sci. 2000 Nov;12(1):51-62. doi: 10.1016/s0928-0987(00)00139-1. Eur J Pharm Sci. 2000. PMID: 11121733

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CYP3A activity in European American and Japanese men using midazolam as an in vivo probe.

Tateishi T, Watanabe M, Nakura H, Asoh M, Shirai H, Mizorogi Y, Kobayashi S, Thummel KE, Wilkinson GR. Tateishi T, et al. Among authors: thummel ke. Clin Pharmacol Ther. 2001 May;69(5):333-9. doi: 10.1067/mcp.2001.115447. Clin Pharmacol Ther. 2001. PMID: 11372001 Clinical Trial.

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Effects of pregnancy on CYP3A and P-glycoprotein activities as measured by disposition of midazolam and digoxin: a University of Washington specialized center of research study.

Hebert MF, Easterling TR, Kirby B, Carr DB, Buchanan ML, Rutherford T, Thummel KE, Fishbein DP, Unadkat JD. Hebert MF, et al. Among authors: thummel ke. Clin Pharmacol Ther. 2008 Aug;84(2):248-53. doi: 10.1038/clpt.2008.1. Epub 2008 Feb 20. Clin Pharmacol Ther. 2008. PMID: 18288078 Clinical Trial.

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Persistent inhibition of CYP3A4 by ketoconazole in modified Caco-2 cells.

Gibbs MA, Baillie MT, Shen DD, Kunze KL, Thummel KE. Gibbs MA, et al. Among authors: thummel ke. Pharm Res. 2000 Mar;17(3):299-305. doi: 10.1023/a:1007550717526. Pharm Res. 2000. PMID: 10801218

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Duration of cytochrome P-450 2E1 (CYP2E1) inhibition and estimation of functional CYP2E1 enzyme half-life after single-dose disulfiram administration in humans.

Emery MG, Jubert C, Thummel KE, Kharasch ED. Emery MG, et al. Among authors: thummel ke. J Pharmacol Exp Ther. 1999 Oct;291(1):213-9. J Pharmacol Exp Ther. 1999. PMID: 10490907 Clinical Trial.

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Reduced duodenal cytochrome P450 3A protein expression and catalytic activity in patients with cirrhosis.

McConn DJ 2nd, Lin YS, Mathisen TL, Blough DK, Xu Y, Hashizume T, Taylor SL, Thummel KE, Shuhart MC. McConn DJ 2nd, et al. Among authors: thummel ke. Clin Pharmacol Ther. 2009 Apr;85(4):387-93. doi: 10.1038/clpt.2008.292. Epub 2009 Feb 11. Clin Pharmacol Ther. 2009. PMID: 19212316 Free PMC article.

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