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Page 1
Thymosin alpha-1.
Ancell CD, Phipps J, Young L. Ancell CD, et al. Am J Health Syst Pharm. 2001 May 15;58(10):879-85; quiz 886-8. doi: 10.1093/ajhp/58.10.886. Am J Health Syst Pharm. 2001. PMID: 11381492 Review.
The pharmacology, pharmacokinetics, clinical efficacy, adverse effects, and dosage and administration of thymosin alpha-1 (TA1) are reviewed. TA1 is a synthetic polypeptide. The drug is in Phase III trials for the treatment of hepatitis C and in Phase II tria …
The pharmacology, pharmacokinetics, clinical efficacy, adverse effects, and dosage and administration of thymosin alpha-1 …
Aging and Thymosin Alpha-1.
Simonova MA, Ivanov I, Shoshina NS, Komyakova AM, Makarov DA, Baranovskii DS, Klabukov ID, Telepenina KP, Atiakshin DA, Shegay PV, Kaprin AD, Stepanenko VN. Simonova MA, et al. Int J Mol Sci. 2025 Nov 27;26(23):11470. doi: 10.3390/ijms262311470. Int J Mol Sci. 2025. PMID: 41373628 Free PMC article. Review.
This leads to reduced T-cell production, chronic inflammation, and increased susceptibility to age-related diseases. Thymosin alpha-1 (Talpha1), a peptide hormone produced by the thymus, exhibits potent immunomodulatory, anti-inflammatory, and antioxidant pro …
This leads to reduced T-cell production, chronic inflammation, and increased susceptibility to age-related diseases. Thymosin alph …
Thymosin alpha 1 treatment for patients with sepsis.
Pei F, Guan X, Wu J. Pei F, et al. Expert Opin Biol Ther. 2018 Jul;18(sup1):71-76. doi: 10.1080/14712598.2018.1484104. Expert Opin Biol Ther. 2018. PMID: 30063866 Review.
In this regard, modifying host immune response may help to eliminate systemic infection and restore organ function. Thymosin alpha 1 (Talpha1), acting as an immune modulator, exerts great biological influence in activating and restoring the dysregulated immun …
In this regard, modifying host immune response may help to eliminate systemic infection and restore organ function. Thymosin alpha …
Thymosin Alpha 1 Plus Routine Treatment for the Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis.
Cao A, Feng F, Zhou X. Cao A, et al. J Coll Physicians Surg Pak. 2024 Dec;34(12):1497-1507. doi: 10.29271/jcpsp.2024.12.1497. J Coll Physicians Surg Pak. 2024. PMID: 39648386
This systematic review was conducted to assess the curative effect of Thymosin alpha 1 in the acute exacerbation of chronic obstructive pulmonary disease (AECOPD) patients. ...More high-quality randomised controlled trials are needed to further confirm Thy …
This systematic review was conducted to assess the curative effect of Thymosin alpha 1 in the acute exacerbation of chr …
Serum thymosin alpha 1 levels in normal and pathological conditions.
Pica F, Gaziano R, Casalinuovo IA, Moroni G, Buè C, Limongi D, D'Agostini C, Tomino C, Perricone R, Palamara AT, Sinibaldi Vallebona P, Garaci E. Pica F, et al. Expert Opin Biol Ther. 2018 Jul;18(sup1):13-21. doi: 10.1080/14712598.2018.1474197. Expert Opin Biol Ther. 2018. PMID: 30063864 Review.
INTRODUCTION: Thymosin alpha 1 (Ta1) is a natural occurring peptide hormone that is crucial for the maintenance of the organism homeostasis. ...
INTRODUCTION: Thymosin alpha 1 (Ta1) is a natural occurring peptide hormone that is crucial for the maintenance of the …
Thymosin alpha 1 alleviates inflammation and prevents infection in patients with severe acute pancreatitis through immune regulation: a systematic review and meta-analysis.
Tian Y, Yao J, Ma Y, Zhang P, Zhou X, Xie W, Tang W. Tian Y, et al. Front Immunol. 2025 Jun 17;16:1571456. doi: 10.3389/fimmu.2025.1571456. eCollection 2025. Front Immunol. 2025. PMID: 40599771 Free PMC article.
BACKGROUND: Immune and inflammatory disorders are part of the complex pathophysiological processes that exacerbate severe acute pancreatitis (SAP) and subsequent infection. Thymosin alpha 1 (Talpha1) is an important immunomodulatory agent in clinical practice …
BACKGROUND: Immune and inflammatory disorders are part of the complex pathophysiological processes that exacerbate severe acute pancreatitis …
Thymosin alpha 1 and HIV-1: recent advances and future perspectives.
Matteucci C, Grelli S, Balestrieri E, Minutolo A, Argaw-Denboba A, Macchi B, Sinibaldi-Vallebona P, Perno CF, Mastino A, Garaci E. Matteucci C, et al. Future Microbiol. 2017 Feb;12:141-155. doi: 10.2217/fmb-2016-0125. Epub 2017 Jan 20. Future Microbiol. 2017. PMID: 28106477 Review.
Actually, antiretroviral therapy may be frequently accompanied by immunological unresponsiveness, persistent inflammatory conditions and inefficient cytotoxic T-cell response. Thymosin alpha 1 is a thymic peptide that demonstrates a peculiar ability to restor …
Actually, antiretroviral therapy may be frequently accompanied by immunological unresponsiveness, persistent inflammatory conditions and ine …
The efficacy of thymosin alpha-1 therapy in moderate to critical COVID-19 patients: a systematic review, meta-analysis, and meta-regression.
Soeroto AY, Suryadinata H, Yanto TA, Hariyanto TI. Soeroto AY, et al. Inflammopharmacology. 2023 Dec;31(6):3317-3325. doi: 10.1007/s10787-023-01354-2. Epub 2023 Oct 16. Inflammopharmacology. 2023. PMID: 37845598
BACKGROUND: Effort to search for the optimal COVID-19 treatment has continuously been attempted. Thymosin alpha-1 have immunomodulatory properties which may be beneficial in case of viral infection. ...The benefits of thymosin alpha-1 on …
BACKGROUND: Effort to search for the optimal COVID-19 treatment has continuously been attempted. Thymosin alpha-1 have …
Thymosin alpha-1 in cancer therapy: Immunoregulation and potential applications.
Wei Y, Zhang Y, Li P, Yan C, Wang L. Wei Y, et al. Int Immunopharmacol. 2023 Apr;117:109744. doi: 10.1016/j.intimp.2023.109744. Epub 2023 Feb 20. Int Immunopharmacol. 2023. PMID: 36812669
Thymosin alpha-1 (Talpha-1) is an immunomodulating polypeptide of 28 amino acids, which was the first peptide isolated from thymic tissue and has been widely used for the treatment of viral infections, immunodeficiencies, and especially malignancies. ...
Thymosin alpha-1 (Talpha-1) is an immunomodulating polypeptide of 28 amino acids, which was the first peptide isolated …
Thymosin alpha-1 treatment in chronic hepatitis B.
Wu X, Jia J, You H. Wu X, et al. Expert Opin Biol Ther. 2015;15 Suppl 1:S129-32. doi: 10.1517/14712598.2015.1007948. Epub 2015 Feb 1. Expert Opin Biol Ther. 2015. PMID: 25640173
INTRODUCTION: Stimulating a successful host immune response may be a promising helpful therapy to achieve elimination of hepatitis B virus (HBV) infection in chronic hepatitis B (CHB). Thymosin alpha-1 (Talpha-1), as an immunomodulatory agent, can enhance T-c …
INTRODUCTION: Stimulating a successful host immune response may be a promising helpful therapy to achieve elimination of hepatitis B virus ( …
860 results