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Year Number of Results
1979 4
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1983 34
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1986 19
1987 31
1988 25
1989 29
1990 18
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1992 27
1993 12
1994 14
1995 15
1996 26
1997 17
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1999 10
2000 22
2001 8
2002 15
2003 14
2004 26
2005 19
2006 13
2007 31
2008 14
2009 21
2010 22
2011 18
2012 16
2013 11
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2015 29
2016 13
2017 15
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2019 14
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2022 18
2023 27
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2025 15
2026 0

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850 results

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Page 1
Thymosin alpha-1 Reverses M2 Polarization of Tumor-Associated Macrophages during Efferocytosis.
Wei YT, Wang XR, Yan C, Huang F, Zhang Y, Liu X, Wen ZF, Sun XT, Zhang Y, Chen YQ, Gao R, Pan N, Wang LX. Wei YT, et al. Cancer Res. 2022 May 16;82(10):1991-2002. doi: 10.1158/0008-5472.CAN-21-4260. Cancer Res. 2022. PMID: 35364609
Here we report that, in the breast tumor microenvironment, thymosin alpha-1 (Talpha-1) significantly reverses M2 polarization of IL10-producing tumor-associated macrophages (TAM) during efferocytosis induced by apoptotic cells. ...In conclusion, Talpha-1 impr …
Here we report that, in the breast tumor microenvironment, thymosin alpha-1 (Talpha-1) significantly reverses M2 polari …
Thymosin alpha-1.
Ancell CD, Phipps J, Young L. Ancell CD, et al. Am J Health Syst Pharm. 2001 May 15;58(10):879-85; quiz 886-8. doi: 10.1093/ajhp/58.10.886. Am J Health Syst Pharm. 2001. PMID: 11381492 Review.
The pharmacology, pharmacokinetics, clinical efficacy, adverse effects, and dosage and administration of thymosin alpha-1 (TA1) are reviewed. TA1 is a synthetic polypeptide. The drug is in Phase III trials for the treatment of hepatitis C and in Phase II tria …
The pharmacology, pharmacokinetics, clinical efficacy, adverse effects, and dosage and administration of thymosin alpha-1 …
Thymosin alpha 1 treatment for patients with sepsis.
Pei F, Guan X, Wu J. Pei F, et al. Expert Opin Biol Ther. 2018 Jul;18(sup1):71-76. doi: 10.1080/14712598.2018.1484104. Expert Opin Biol Ther. 2018. PMID: 30063866 Review.
In this regard, modifying host immune response may help to eliminate systemic infection and restore organ function. Thymosin alpha 1 (Talpha1), acting as an immune modulator, exerts great biological influence in activating and restoring the dysregulated immun …
In this regard, modifying host immune response may help to eliminate systemic infection and restore organ function. Thymosin alpha …
Thymosin Alpha 1 Plus Routine Treatment for the Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis.
Cao A, Feng F, Zhou X. Cao A, et al. J Coll Physicians Surg Pak. 2024 Dec;34(12):1497-1507. doi: 10.29271/jcpsp.2024.12.1497. J Coll Physicians Surg Pak. 2024. PMID: 39648386
This systematic review was conducted to assess the curative effect of Thymosin alpha 1 in the acute exacerbation of chronic obstructive pulmonary disease (AECOPD) patients. ...More high-quality randomised controlled trials are needed to further confirm Thy …
This systematic review was conducted to assess the curative effect of Thymosin alpha 1 in the acute exacerbation of chr …
Aging and Thymosin Alpha-1.
Simonova MA, Ivanov I, Shoshina NS, Komyakova AM, Makarov DA, Baranovskii DS, Klabukov ID, Telepenina KP, Atiakshin DA, Shegay PV, Kaprin AD, Stepanenko VN. Simonova MA, et al. Int J Mol Sci. 2025 Nov 27;26(23):11470. doi: 10.3390/ijms262311470. Int J Mol Sci. 2025. PMID: 41373628 Free PMC article. Review.
This leads to reduced T-cell production, chronic inflammation, and increased susceptibility to age-related diseases. Thymosin alpha-1 (Talpha1), a peptide hormone produced by the thymus, exhibits potent immunomodulatory, anti-inflammatory, and antioxidant pro …
This leads to reduced T-cell production, chronic inflammation, and increased susceptibility to age-related diseases. Thymosin alph …
Thymosin alpha 1 and HIV-1: recent advances and future perspectives.
Matteucci C, Grelli S, Balestrieri E, Minutolo A, Argaw-Denboba A, Macchi B, Sinibaldi-Vallebona P, Perno CF, Mastino A, Garaci E. Matteucci C, et al. Future Microbiol. 2017 Feb;12:141-155. doi: 10.2217/fmb-2016-0125. Epub 2017 Jan 20. Future Microbiol. 2017. PMID: 28106477 Review.
Actually, antiretroviral therapy may be frequently accompanied by immunological unresponsiveness, persistent inflammatory conditions and inefficient cytotoxic T-cell response. Thymosin alpha 1 is a thymic peptide that demonstrates a peculiar ability to restor …
Actually, antiretroviral therapy may be frequently accompanied by immunological unresponsiveness, persistent inflammatory conditions and ine …
Serum thymosin alpha 1 levels in normal and pathological conditions.
Pica F, Gaziano R, Casalinuovo IA, Moroni G, Buè C, Limongi D, D'Agostini C, Tomino C, Perricone R, Palamara AT, Sinibaldi Vallebona P, Garaci E. Pica F, et al. Expert Opin Biol Ther. 2018 Jul;18(sup1):13-21. doi: 10.1080/14712598.2018.1474197. Expert Opin Biol Ther. 2018. PMID: 30063864 Review.
INTRODUCTION: Thymosin alpha 1 (Ta1) is a natural occurring peptide hormone that is crucial for the maintenance of the organism homeostasis. ...
INTRODUCTION: Thymosin alpha 1 (Ta1) is a natural occurring peptide hormone that is crucial for the maintenance of the …
The efficacy of thymosin alpha-1 therapy in moderate to critical COVID-19 patients: a systematic review, meta-analysis, and meta-regression.
Soeroto AY, Suryadinata H, Yanto TA, Hariyanto TI. Soeroto AY, et al. Inflammopharmacology. 2023 Dec;31(6):3317-3325. doi: 10.1007/s10787-023-01354-2. Epub 2023 Oct 16. Inflammopharmacology. 2023. PMID: 37845598
BACKGROUND: Effort to search for the optimal COVID-19 treatment has continuously been attempted. Thymosin alpha-1 have immunomodulatory properties which may be beneficial in case of viral infection. ...The benefits of thymosin alpha-1 on …
BACKGROUND: Effort to search for the optimal COVID-19 treatment has continuously been attempted. Thymosin alpha-1 have …
Thymosin alpha-1 in cancer therapy: Immunoregulation and potential applications.
Wei Y, Zhang Y, Li P, Yan C, Wang L. Wei Y, et al. Int Immunopharmacol. 2023 Apr;117:109744. doi: 10.1016/j.intimp.2023.109744. Epub 2023 Feb 20. Int Immunopharmacol. 2023. PMID: 36812669
Thymosin alpha-1 (Talpha-1) is an immunomodulating polypeptide of 28 amino acids, which was the first peptide isolated from thymic tissue and has been widely used for the treatment of viral infections, immunodeficiencies, and especially malignancies. ...
Thymosin alpha-1 (Talpha-1) is an immunomodulating polypeptide of 28 amino acids, which was the first peptide isolated …
Clinical applications of thymosin alpha-1.
Goldstein AL. Goldstein AL. Cancer Invest. 1994;12(5):545-7. doi: 10.3109/07357909409021415. Cancer Invest. 1994. PMID: 7922712 Review. No abstract available.
850 results