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Page 1
Withdrawal reactions following cessation of central alpha-adrenergic receptor agonists.
Reid JL, Campbell BC, Hamilton CA. Reid JL, et al. Hypertension. 1984 Sep-Oct;6(5 Pt 2):II71-5. doi: 10.1161/01.hyp.6.5_pt_2.ii71. Hypertension. 1984. PMID: 6150002 Review.
Reactions are most commonly observed after short-acting imidazoline drugs such as clonidine and tiamenidine. Reactions are less common after longer acting agents such as guanfacine. ...
Reactions are most commonly observed after short-acting imidazoline drugs such as clonidine and tiamenidine. Reactions are less commo …
Studies on the pre- and postjunctional activities of alpha-adrenoreceptor agonists and their cardiovascular effects in the anaesthetized rat.
Doxey JC, Frank LW, Hersom AS. Doxey JC, et al. J Auton Pharmacol. 1981 Mar;1(2):157-69. doi: 10.1111/j.1474-8673.1981.tb00508.x. J Auton Pharmacol. 1981. PMID: 6121811
In contrast oxymetazoline and St 91 produced marked initial pressor responses and the secondary reduction in blood pressure was absent. Clonidine and tiamenidine produced marked initial pressor responses followed by secondary hypotensive effects. ...In contrast blood press …
In contrast oxymetazoline and St 91 produced marked initial pressor responses and the secondary reduction in blood pressure was absent. Clon …
Electrophysiologic and hemodynamic effects of chronic oral therapy with the alpha 2-agonists clonidine and tiamenidine in hypertensive volunteers.
Roden DM, Nadeau JH, Primm RK. Roden DM, et al. Clin Pharmacol Ther. 1988 Jun;43(6):648-54. doi: 10.1038/clpt.1988.90. Clin Pharmacol Ther. 1988. PMID: 2897889
We have evaluated the electrophysiologic and hemodynamic effects of chronic oral treatment with either clonidine (0.2 to 0.5 mg every 12 hours; n = 7) or another centrally active alpha 2-agonist, tiamenidine (0.5 to 1.5 mg every 12 hours; n = 7), in otherwise healthy hyper …
We have evaluated the electrophysiologic and hemodynamic effects of chronic oral treatment with either clonidine (0.2 to 0.5 mg every 12 hou …
Cardiovascular withdrawal effects of clonidine and tiamenidine on abrupt cessation of oral treatment in conscious cats.
Finch L, Hicks PE. Finch L, et al. J Pharm Pharmacol. 1980 Apr;32(4):272-7. doi: 10.1111/j.2042-7158.1980.tb12911.x. J Pharm Pharmacol. 1980. PMID: 6103057
In conscious renal hypertensive cats prepared with permanent indwelling arterial catheters oral administration of clonidine (0.05 mg x 3 daily) clonidine (0.0125 mg x 3 daily), or tiamenidine (0.25 mg x 3 daily) induced hypotension and bradycardia during 6 days of treatmen …
In conscious renal hypertensive cats prepared with permanent indwelling arterial catheters oral administration of clonidine (0.05 mg x 3 dai …
Changes in blood pressure, heart rate, and sympathetic activity on abrupt withdrawal of tiamenidine (HOE 440) in essential hypertension.
Campbell BC, Elliott HL, Hamilton CA, Reid JL. Campbell BC, et al. Eur J Clin Pharmacol. 1980 Nov;18(6):449-54. doi: 10.1007/BF00874654. Eur J Clin Pharmacol. 1980. PMID: 7461012 Clinical Trial.
Ten patients, four male, six female, aged 28--64 years, with essential hypertension, were treated for one year with an imidazoline derivative, tiamenidine. Blood pressure fell from an average of 178/108 mm Hg pretreatment to 152/86 mm Hg after 1 year. Tiamenidine wa …
Ten patients, four male, six female, aged 28--64 years, with essential hypertension, were treated for one year with an imidazoline derivativ …
Changes in blood pressure, plasma catecholamines and plasma renin activity during and after treatment with tiamenidine and clonidine.
Hansson BG, Hökfelt B. Hansson BG, et al. Br J Clin Pharmacol. 1981 Jan;11(1):73-7. doi: 10.1111/j.1365-2125.1981.tb01105.x. Br J Clin Pharmacol. 1981. PMID: 7011348 Free PMC article. Clinical Trial.
1 Tiamenidine (Hoe 440) is an imidazoline with blood pressure lowering properties. ...Levels of NA, Ad, PRA were reduced during treatment. 5 During withdrawal of either drug there was rebound of blood pressure and NA, Ad, PRA, overshooting baseline levels. 6 The withdrawal …
1 Tiamenidine (Hoe 440) is an imidazoline with blood pressure lowering properties. ...Levels of NA, Ad, PRA were reduced during treat …
An alternative method of assessing changes in salivary flow: comparison of the effects of clonidine and tiamenidine (HOE 440).
Findlay D, Lawrence JR. Findlay D, et al. Eur J Clin Pharmacol. 1978 Dec 1;14(4):231-5. doi: 10.1007/BF00560455. Eur J Clin Pharmacol. 1978. PMID: 729618 Clinical Trial.
These changes were maximal between 2 and 6 h and were more marked after clonidine than after tiamenidine. As tiamenidine 1.0 mg did not produce a hypotensive effect equivalent to clonidine 0.3 mg direct comparison of side-effects attributable to these agents proved …
These changes were maximal between 2 and 6 h and were more marked after clonidine than after tiamenidine. As tiamenidine 1.0 m …
Withdrawal phenomena in subjects with essential hypertension on clonidine or tiamenidine.
Hamilton BP, Mersey JH, Hamilton J, Kuzbida G, Pavlis R, Levinson P. Hamilton BP, et al. Clin Pharmacol Ther. 1984 Nov;36(5):628-33. doi: 10.1038/clpt.1984.232. Clin Pharmacol Ther. 1984. PMID: 6488684
The incidence and pathogenesis of withdrawal phenomena with the centrally acting drugs clonidine (CLON) and tiamenidine (TIAM) were evaluated. Thirty subjects with hypertension on hydrochlorothiazide (HCTZ) were randomized to TIAM or CLON. ...
The incidence and pathogenesis of withdrawal phenomena with the centrally acting drugs clonidine (CLON) and tiamenidine (TIAM) were e …
Displacement of [3H]clonidine binding by clonidine analogues in membranes from rat cerebral cortex.
Summers RJ, Jarrott B, Louis WJ. Summers RJ, et al. Eur J Pharmacol. 1980 Aug 29;66(2-3):233-41. doi: 10.1016/0014-2999(80)90147-8. Eur J Pharmacol. 1980. PMID: 6254785
Seven imidazolidine derivatives with known alpha-adrenoceptor activity were potent displacers of [3H]clonidine binding: the order of potency being 14,304-18 > naphazoline > clonidine > lofexidine and tiamenidine > CP18,534 > ST600 > ST91. Five 'clonidine- …
Seven imidazolidine derivatives with known alpha-adrenoceptor activity were potent displacers of [3H]clonidine binding: the order of potency …
25 results