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Efficacy of cancer gene therapy in aging: adenocarcinoma cells engineered to release IL-2 are rejected but do not induce tumor specific immune memory in old mice.
Provinciali M, Argentati K, Tibaldi A. Provinciali M, et al. Among authors: tibaldi a. Gene Ther. 2000 Apr;7(7):624-32. doi: 10.1038/sj.gt.3301131. Gene Ther. 2000. PMID: 10819579 Free article.
Chemical shift imaging at 4.7 tesla of thymus in young and old mice.
Marzola P, Mocchegiani E, Nicolato E, Tibaldi A, Sbarbati A, Osculati F. Marzola P, et al. Among authors: tibaldi a. J Magn Reson Imaging. 1999 Jul;10(1):97-101. doi: 10.1002/(sici)1522-2586(199907)10:1<97::aid-jmri14>3.0.co;2-y. J Magn Reson Imaging. 1999. PMID: 10398984
Melatonin administration in tumor-bearing mice (intact and pinealectomized) in relation to stress, zinc, thymulin and IL-2.
Mocchegiani E, Perissin L, Santarelli L, Tibaldi A, Zorzet S, Rapozzi V, Giacconi R, Bulian D, Giraldi T. Mocchegiani E, et al. Among authors: tibaldi a. Int J Immunopharmacol. 1999 Jan;21(1):27-46. doi: 10.1016/s0192-0561(98)00067-8. Int J Immunopharmacol. 1999. PMID: 10411280
Presence of links between zinc and melatonin during the circadian cycle in old mice: effects on thymic endocrine activity and on the survival.
Mocchegiani E, Santarelli L, Tibaldi A, Muzzioli M, Bulian D, Cipriano K, Olivieri F, Fabris N. Mocchegiani E, et al. Among authors: tibaldi a. J Neuroimmunol. 1998 Jun 15;86(2):111-22. doi: 10.1016/s0165-5728(97)00253-1. J Neuroimmunol. 1998. PMID: 9663556
Links between zinc and melatonin in old melatonin treated mice with a reconstitution of thymic functions have been recently documented. ...A recovery of the nocturnal peaks of thymulin plasma levels and of the number of thymulin-secreting cells with a synchro …
Links between zinc and melatonin in old melatonin treated mice with a reconstitution of thymic functions have been recently documente …
Zinc and metallothioneins on cellular immune effectiveness during liver regeneration in young and old mice.
Mocchegiani E, Verbanac D, Santarelli L, Tibaldi A, Muzzioli M, Radosevic-Stasic B, Milin C. Mocchegiani E, et al. Among authors: tibaldi a. Life Sci. 1997;61(12):1125-45. doi: 10.1016/s0024-3205(97)00646-2. Life Sci. 1997. PMID: 9315504
The preminence of a liver extrathymic T-cell pathway after pHx or during aging has been suggested. Thus the study of pHx in young and old mice may offer a good model to better understand the role played both by thymic involution and by liver extrathymic T-cell pathw …
The preminence of a liver extrathymic T-cell pathway after pHx or during aging has been suggested. Thus the study of pHx in young and …
Effect of melatonin and pineal grafting on thymocyte apoptosis in aging mice.
Provinciali M, Di Stefano G, Bulian D, Tibaldi A, Fabris N. Provinciali M, et al. Among authors: tibaldi a. Mech Ageing Dev. 1996 Sep 9;90(1):1-19. doi: 10.1016/0047-6374(96)01746-0. Mech Ageing Dev. 1996. PMID: 8844645
Balb/c mice (17-18 months old) were given supplements of MEL (40-50 micrograms/day/mouse) or grafted with a young pineal gland and then sacrificed after 8 months. ...DEX caused a bigger loss of G D /G 1 phase cells in MEL treated mice than in old untreated mice. The …
Balb/c mice (17-18 months old) were given supplements of MEL (40-50 micrograms/day/mouse) or grafted with a young pineal gland and th …
The immuno-reconstituting effect of melatonin or pineal grafting and its relation to zinc pool in aging mice.
Mocchegiani E, Bulian D, Santarelli L, Tibaldi A, Muzzioli M, Pierpaoli W, Fabris N. Mocchegiani E, et al. Among authors: tibaldi a. J Neuroimmunol. 1994 Sep;53(2):189-201. doi: 10.1016/0165-5728(94)90029-9. J Neuroimmunol. 1994. PMID: 8071433
A restoration of cortical thymic volume, as detected by the percentage of tissue in active proliferation, is also observed in old mice after both treatments. ...Melatonin treatment or pineal graft induce also a restoration of the altered zinc turnover in aged mice w
A restoration of cortical thymic volume, as detected by the percentage of tissue in active proliferation, is also observed in old mic
Role of the low zinc bioavailability on cellular immune effectiveness in cystic fibrosis.
Mocchegiani E, Provinciali M, Di Stefano G, Nobilini A, Caramia G, Santarelli L, Tibaldi A, Fabris N. Mocchegiani E, et al. Among authors: tibaldi a. Clin Immunol Immunopathol. 1995 Jun;75(3):214-24. doi: 10.1006/clin.1995.1074. Clin Immunol Immunopathol. 1995. PMID: 7539347
In particular, zinc is required to confer biological activity to thymulin (ZnFTS), a biochemically defined thymic hormone with a modulating action on cell-mediated immunity. ...A strict correlation exists between zinc and thymic hormone-saturable fraction (r …
In particular, zinc is required to confer biological activity to thymulin (ZnFTS), a biochemically defined thymic hormone with a
The zinc-melatonin interrelationship. A working hypothesis.
Mocchegiani E, Bulian D, Santarelli L, Tibaldi A, Pierpaoli W, Fabris N. Mocchegiani E, et al. Among authors: tibaldi a. Ann N Y Acad Sci. 1994 May 31;719:298-307. doi: 10.1111/j.1749-6632.1994.tb56838.x. Ann N Y Acad Sci. 1994. PMID: 8010602 Review. No abstract available.
Role of zinc and alpha2 macroglobulin on thymic endocrine activity and on peripheral immune efficiency (natural killer activity and interleukin 2) in cervical carcinoma.
Mocchegiani E, Ciavattini A, Santarelli L, Tibaldi A, Muzzioli M, Bonazzi P, Giacconi R, Fabris N, Garzetti GG. Mocchegiani E, et al. Among authors: tibaldi a. Br J Cancer. 1999 Jan;79(2):244-50. doi: 10.1038/sj.bjc.6690040. Br J Cancer. 1999. PMID: 9888464 Free PMC article.
Because alpha2-macroglobulin has a binding affinity (Kd) for zinc that is higher than does thymulin, it may play a key role in immune efficiency in cancer. ...These data suggest that an increase in alpha2-macroglobulin, which competes with thymulin for zinc binding, …
Because alpha2-macroglobulin has a binding affinity (Kd) for zinc that is higher than does thymulin, it may play a key role in …
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