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Investigation of specificity determinants in bacterial tRNA-guanine transglycosylase reveals queuine, the substrate of its eucaryotic counterpart, as inhibitor.
PLoS One. 2013 May 21;8(5):e64240. doi: 10.1371/journal.pone.0064240. Print 2013.
PLoS One. 2013.
PMID: 23704982
Free PMC article.
IspE inhibitors identified by a combination of in silico and in vitro high-throughput screening.
Tidten-Luksch N, Grimaldi R, Torrie LS, Frearson JA, Hunter WN, Brenk R.
Tidten-Luksch N, et al.
PLoS One. 2012;7(4):e35792. doi: 10.1371/journal.pone.0035792. Epub 2012 Apr 25.
PLoS One. 2012.
PMID: 22563402
Free PMC article.
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De novo design of protein kinase inhibitors by in silico identification of hinge region-binding fragments.
Urich R, Wishart G, Kiczun M, Richters A, Tidten-Luksch N, Rauh D, Sherborne B, Wyatt PG, Brenk R.
Urich R, et al. Among authors: tidten luksch n.
ACS Chem Biol. 2013 May 17;8(5):1044-52. doi: 10.1021/cb300729y. Epub 2013 Mar 27.
ACS Chem Biol. 2013.
PMID: 23534475
Free PMC article.
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Inverse agonist efficacy of selatogrel blunts constitutive P2Y12 receptor signaling by inducing the inactive receptor conformation.
Pons V, Garcia C, Tidten-Luksch N, Mac Sweeney A, Caroff E, Galés C, Riederer MA.
Pons V, et al. Among authors: tidten luksch n.
Biochem Pharmacol. 2022 Dec;206:115291. doi: 10.1016/j.bcp.2022.115291. Epub 2022 Oct 25.
Biochem Pharmacol. 2022.
PMID: 36306820
Free article.
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Discovery of Novel Inhibitors of LpxC Displaying Potent in Vitro Activity against Gram-Negative Bacteria.
Surivet JP, Panchaud P, Specklin JL, Diethelm S, Blumstein AC, Gauvin JC, Jacob L, Masse F, Mathieu G, Mirre A, Schmitt C, Lange R, Tidten-Luksch N, Gnerre C, Seeland S, Herrmann C, Seiler P, Enderlin-Paput M, Mac Sweeney A, Wicki M, Hubschwerlen C, Ritz D, Rueedi G.
Surivet JP, et al. Among authors: tidten luksch n.
J Med Chem. 2020 Jan 9;63(1):66-87. doi: 10.1021/acs.jmedchem.9b01604. Epub 2019 Dec 24.
J Med Chem. 2020.
PMID: 31804826
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