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Genetic analysis as a valuable key to diagnosis and treatment of periodic Fever.
Simon A, van Deuren M, Tighe PJ, van der Meer JW, Drenth JP. Simon A, et al. Among authors: tighe pj. Arch Intern Med. 2001 Nov 12;161(20):2491-3. doi: 10.1001/archinte.161.20.2491. Arch Intern Med. 2001. PMID: 11700162
Systemic cytokine levels and the effects of etanercept in TNF receptor-associated periodic syndrome (TRAPS) involving a C33Y mutation in TNFRSF1A.
Nowlan ML, Drewe E, Bulsara H, Esposito N, Robins RA, Tighe PJ, Powell RJ, Todd I. Nowlan ML, et al. Among authors: tighe pj. Rheumatology (Oxford). 2006 Jan;45(1):31-7. doi: 10.1093/rheumatology/kei090. Epub 2005 Nov 15. Rheumatology (Oxford). 2006. PMID: 16287931
Role of interleukin-6 in a patient with tumor necrosis factor receptor-associated periodic syndrome: assessment of outcomes following treatment with the anti-interleukin-6 receptor monoclonal antibody tocilizumab.
Vaitla PM, Radford PM, Tighe PJ, Powell RJ, McDermott EM, Todd I, Drewe E. Vaitla PM, et al. Among authors: tighe pj. Arthritis Rheum. 2011 Apr;63(4):1151-5. doi: 10.1002/art.30215. Arthritis Rheum. 2011. PMID: 21225679
Mutant forms of tumour necrosis factor receptor I that occur in TNF-receptor-associated periodic syndrome retain signalling functions but show abnormal behaviour.
Todd I, Radford PM, Draper-Morgan KA, McIntosh R, Bainbridge S, Dickinson P, Jamhawi L, Sansaridis M, Huggins ML, Tighe PJ, Powell RJ. Todd I, et al. Among authors: tighe pj. Immunology. 2004 Sep;113(1):65-79. doi: 10.1111/j.1365-2567.2004.01942.x. Immunology. 2004. PMID: 15312137 Free PMC article.
Shedding of mutant tumor necrosis factor receptor superfamily 1A associated with tumor necrosis factor receptor-associated periodic syndrome: differences between cell types.
Huggins ML, Radford PM, McIntosh RS, Bainbridge SE, Dickinson P, Draper-Morgan KA, Tighe PJ, Powell RJ, Todd I. Huggins ML, et al. Among authors: tighe pj. Arthritis Rheum. 2004 Aug;50(8):2651-9. doi: 10.1002/art.20380. Arthritis Rheum. 2004. PMID: 15334481
Modeling of tumor necrosis factor receptor superfamily 1A mutants associated with tumor necrosis factor receptor-associated periodic syndrome indicates misfolding consistent with abnormal function.
Rebelo SL, Bainbridge SE, Amel-Kashipaz MR, Radford PM, Powell RJ, Todd I, Tighe PJ. Rebelo SL, et al. Among authors: tighe pj. Arthritis Rheum. 2006 Aug;54(8):2674-87. doi: 10.1002/art.21964. Arthritis Rheum. 2006. PMID: 16871532
Novel markers of inflammation identified in tumor necrosis factor receptor-associated periodic syndrome (TRAPS) by transcriptomic analysis of effects of TRAPS-associated tumor necrosis factor receptor type I mutations in an endothelial cell line.
Rebelo SL, Amel-Kashipaz MR, Radford PM, Bainbridge SE, Fiets R, Fang J, McDermott EM, Powell RJ, Todd I, Tighe PJ. Rebelo SL, et al. Among authors: tighe pj. Arthritis Rheum. 2009 Jan;60(1):269-80. doi: 10.1002/art.24147. Arthritis Rheum. 2009. PMID: 19116900
Mutant tumor necrosis factor receptor associated with tumor necrosis factor receptor-associated periodic syndrome is altered antigenically and is retained within patients' leukocytes.
Todd I, Radford PM, Daffa N, Bainbridge SE, Powell RJ, Tighe PJ. Todd I, et al. Among authors: tighe pj. Arthritis Rheum. 2007 Aug;56(8):2765-73. doi: 10.1002/art.22740. Arthritis Rheum. 2007. PMID: 17665435
Elevated CD16 expression by monocytes from patients with tumor necrosis factor receptor-associated periodic syndrome.
Todd I, Radford PM, Ziegler-Heitbrock L, Ghaemmaghami AM, Powell RJ, Tighe PJ. Todd I, et al. Among authors: tighe pj. Arthritis Rheum. 2007 Dec;56(12):4182-8. doi: 10.1002/art.23133. Arthritis Rheum. 2007. PMID: 18050249
Cell surface expression of TNFRI in tumor necrosis factor receptor-associated periodic syndrome: comment on the article by Nedjai et al.
Todd I, Tighe P, Rebelo S, Powell R. Todd I, et al. Arthritis Rheum. 2008 Jul;58(7):2213-4; author reply 2214-5. doi: 10.1002/art.23551. Arthritis Rheum. 2008. PMID: 18576329 No abstract available.
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