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Lysophosphatidic acid mediates the rapid activation of platelets and endothelial cells by mildly oxidized low density lipoprotein and accumulates in human atherosclerotic lesions.
Siess W, Zangl KJ, Essler M, Bauer M, Brandl R, Corrinth C, Bittman R, Tigyi G, Aepfelbacher M. Siess W, et al. Among authors: tigyi g. Proc Natl Acad Sci U S A. 1999 Jun 8;96(12):6931-6. doi: 10.1073/pnas.96.12.6931. Proc Natl Acad Sci U S A. 1999. PMID: 10359816 Free PMC article.
Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activators of PPARgamma, and inhibitors of autotaxin.
Durgam GG, Virag T, Walker MD, Tsukahara R, Yasuda S, Liliom K, van Meeteren LA, Moolenaar WH, Wilke N, Siess W, Tigyi G, Miller DD. Durgam GG, et al. Among authors: tigyi g. J Med Chem. 2005 Jul 28;48(15):4919-30. doi: 10.1021/jm049609r. J Med Chem. 2005. PMID: 16033271
224 results