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The anti-fibrotic effects of CCN1/CYR61 in primary portal myofibroblasts are mediated through induction of reactive oxygen species resulting in cellular senescence, apoptosis and attenuated TGF-β signaling.
Borkham-Kamphorst E, Schaffrath C, Van de Leur E, Haas U, Tihaa L, Meurer SK, Nevzorova YA, Liedtke C, Weiskirchen R. Borkham-Kamphorst E, et al. Among authors: tihaa l. Biochim Biophys Acta. 2014 May;1843(5):902-14. doi: 10.1016/j.bbamcr.2014.01.023. Epub 2014 Jan 31. Biochim Biophys Acta. 2014. PMID: 24487063 Free article.
12 results