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Structure and autoregulation of the insulin-like growth factor 1 receptor kinase.
Favelyukis S, Till JH, Hubbard SR, Miller WT. Favelyukis S, et al. Among authors: till jh. Nat Struct Biol. 2001 Dec;8(12):1058-63. doi: 10.1038/nsb721. Nat Struct Biol. 2001. PMID: 11694888
Crystal structure of the MuSK tyrosine kinase: insights into receptor autoregulation.
Till JH, Becerra M, Watty A, Lu Y, Ma Y, Neubert TA, Burden SJ, Hubbard SR. Till JH, et al. Structure. 2002 Sep;10(9):1187-96. doi: 10.1016/s0969-2126(02)00814-6. Structure. 2002. PMID: 12220490 Free article.
Structural and biochemical evidence for an autoinhibitory role for tyrosine 984 in the juxtamembrane region of the insulin receptor.
Li S, Covino ND, Stein EG, Till JH, Hubbard SR. Li S, et al. Among authors: till jh. J Biol Chem. 2003 Jul 11;278(28):26007-14. doi: 10.1074/jbc.M302425200. Epub 2003 Apr 21. J Biol Chem. 2003. PMID: 12707268 Free article.
Crystallographic and solution studies of an activation loop mutant of the insulin receptor tyrosine kinase: insights into kinase mechanism.
Till JH, Ablooglu AJ, Frankel M, Bishop SM, Kohanski RA, Hubbard SR. Till JH, et al. J Biol Chem. 2001 Mar 30;276(13):10049-55. doi: 10.1074/jbc.M010161200. Epub 2000 Dec 21. J Biol Chem. 2001. PMID: 11124964 Free article.
Protein tyrosine kinase structure and function.
Hubbard SR, Till JH. Hubbard SR, et al. Among authors: till jh. Annu Rev Biochem. 2000;69:373-98. doi: 10.1146/annurev.biochem.69.1.373. Annu Rev Biochem. 2000. PMID: 10966463 Review.
Probing the catalytic mechanism of the insulin receptor kinase with a tetrafluorotyrosine-containing peptide substrate.
Ablooglu AJ, Till JH, Kim K, Parang K, Cole PA, Hubbard SR, Kohanski RA. Ablooglu AJ, et al. Among authors: till jh. J Biol Chem. 2000 Sep 29;275(39):30394-8. doi: 10.1074/jbc.M003524200. J Biol Chem. 2000. PMID: 10869355
Engineering the substrate specificity of the Abl tyrosine kinase.
Till JH, Chan PM, Miller WT. Till JH, et al. J Biol Chem. 1999 Feb 19;274(8):4995-5003. doi: 10.1074/jbc.274.8.4995. J Biol Chem. 1999. PMID: 9988744
Precision substrate targeting of protein kinases v-Abl and c-Src.
Lee TR, Till JH, Lawrence DS, Miller WT. Lee TR, et al. Among authors: till jh. J Biol Chem. 1995 Nov 10;270(45):27022-6. doi: 10.1074/jbc.270.45.27022. J Biol Chem. 1995. PMID: 7592951
Use of synthetic peptide libraries and phosphopeptide-selective mass spectrometry to probe protein kinase substrate specificity.
Till JH, Annan RS, Carr SA, Miller WT. Till JH, et al. J Biol Chem. 1994 Mar 11;269(10):7423-8. J Biol Chem. 1994. PMID: 8125961
Mechanism-based design of a protein kinase inhibitor.
Parang K, Till JH, Ablooglu AJ, Kohanski RA, Hubbard SR, Cole PA. Parang K, et al. Among authors: till jh. Nat Struct Biol. 2001 Jan;8(1):37-41. doi: 10.1038/83028. Nat Struct Biol. 2001. PMID: 11135668
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