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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1970 3
1971 4
1972 10
1973 8
1974 13
1975 15
1976 28
1977 43
1978 19
1979 24
1980 21
1981 21
1982 8
1983 15
1984 16
1985 15
1986 13
1987 6
1988 10
1989 6
1990 9
1991 10
1992 6
1993 2
1994 4
1995 6
1996 9
1997 3
1998 6
1999 1
2000 6
2001 7
2002 8
2003 1
2004 4
2005 5
2006 4
2007 7
2008 9
2009 1
2010 3
2011 4
2012 6
2013 8
2014 2
2015 3
2016 3
2017 1
2018 5
2019 6
2020 11
2021 4
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455 results
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Tilorone: a Broad-Spectrum Antiviral Invented in the USA and Commercialized in Russia and beyond.
Ekins S, Lane TR, Madrid PB. Ekins S, et al. Pharm Res. 2020 Mar 25;37(4):71. doi: 10.1007/s11095-020-02799-8. Pharm Res. 2020. PMID: 32215760 Free PMC article.
For the last 50 years we have known of a broad-spectrum agent tilorone dihydrochloride (Tilorone). This is a small-molecule orally bioavailable drug that was originally discovered in the USA and is currently used clinically as an antiviral in Russia and the Ukraine. …
For the last 50 years we have known of a broad-spectrum agent tilorone dihydrochloride (Tilorone). This is a small-molecule or …
Tilorone, a Broad-Spectrum Antiviral for Emerging Viruses.
Ekins S, Madrid PB. Ekins S, et al. Antimicrob Agents Chemother. 2020 Apr 21;64(5):e00440-20. doi: 10.1128/AAC.00440-20. Print 2020 Apr 21. Antimicrob Agents Chemother. 2020. PMID: 32205350 Free PMC article.
Tilorone is a 50-year-old synthetic small-molecule compound with antiviral activity that is proposed to induce interferon after oral administration. ...
Tilorone is a 50-year-old synthetic small-molecule compound with antiviral activity that is proposed to induce interferon after oral …
Efficacy of Tilorone Dihydrochloride against Ebola Virus Infection.
Ekins S, Lingerfelt MA, Comer JE, Freiberg AN, Mirsalis JC, O'Loughlin K, Harutyunyan A, McFarlane C, Green CE, Madrid PB. Ekins S, et al. Antimicrob Agents Chemother. 2018 Jan 25;62(2):e01711-17. doi: 10.1128/AAC.01711-17. Print 2018 Feb. Antimicrob Agents Chemother. 2018. PMID: 29133569 Free PMC article.
Tilorone dihydrochloride (tilorone) is a small-molecule, orally bioavailable drug that is used clinically as an antiviral outside the United States. A machine-learning model trained on anti-Ebola virus (EBOV) screening data previously identified tilorone as a …
Tilorone dihydrochloride (tilorone) is a small-molecule, orally bioavailable drug that is used clinically as an antiviral outs …
Repurposing the Ebola and Marburg Virus Inhibitors Tilorone, Quinacrine and Pyronaridine: In vitro Activity Against SARS-CoV-2 and Potential Mechanisms.
Puhl AC, Fritch EJ, Lane TR, Tse LV, Yount BL, Sacramento CQ, Tavella TA, Costa FTM, Weston S, Logue J, Frieman M, Premkumar L, Pearce KH, Hurst BL, Andrade CH, Levi JA, Johnson NJ, Kisthardt SC, Scholle F, Souza TML, Moorman NJ, Baric RS, Madrid P, Ekins S. Puhl AC, et al. bioRxiv. 2020 Dec 2:2020.12.01.407361. doi: 10.1101/2020.12.01.407361. Preprint. bioRxiv. 2020. PMID: 33299990 Free PMC article. Updated.
Testing other small molecule drugs that are active against Ebola virus would seem a reasonable strategy to evaluate their potential for SARS-CoV-2. We have previously repurposed pyronaridine, tilorone and quinacrine (from malaria, influenza, and antiprotozoal uses, respect …
Testing other small molecule drugs that are active against Ebola virus would seem a reasonable strategy to evaluate their potential for SARS …
The effects of coadministration of tilorone dihydrochloride and culture supernatants from Lactobacillus reuteri on the mouse hepatoma cell line.
Alem M, Shahbazfar AA, Zare P, Tayefi-Nasrabadi H. Alem M, et al. J Cancer Res Ther. 2019 Jan-Mar;15(1):176-184. doi: 10.4103/jcrt.JCRT_41_17. J Cancer Res Ther. 2019. PMID: 30880776 Free article.
CONTEXT: Tilorone dihydrochloride is a therapeutic agent with a different mechanism in cancer. ...RT-PCR analysis showed that tilorone dihydrochloride induced upregulation and downregulation in expression of Bax and Bcl-2, respectively. ...
CONTEXT: Tilorone dihydrochloride is a therapeutic agent with a different mechanism in cancer. ...RT-PCR analysis showed that tilo …
Toward the Target: Tilorone, Quinacrine, and Pyronaridine Bind to Ebola Virus Glycoprotein.
Lane TR, Ekins S. Lane TR, et al. ACS Med Chem Lett. 2020 Jul 23;11(8):1653-1658. doi: 10.1021/acsmedchemlett.0c00298. eCollection 2020 Aug 13. ACS Med Chem Lett. 2020. PMID: 32832035
Pyronaridine, tilorone, and quinacrine were recently identified by a machine learning model and demonstrated in vitro and in vivo activity against Ebola virus (EBOV) and represent viable candidates for drug repurposing. ...These drugs have now been docked into the crystal …
Pyronaridine, tilorone, and quinacrine were recently identified by a machine learning model and demonstrated in vitro and in vivo act …
Tilorone hydrochloride: the drug profile.
Chandra P, Wright GJ. Chandra P, et al. Top Curr Chem. 1977;72:125-48. doi: 10.1007/BFb0048451. Top Curr Chem. 1977. PMID: 339405 Review. No abstract available.
Repurposing Pyramax, quinacrine and tilorone as treatments for Ebola virus disease.
Lane TR, Dyall J, Mercer L, Goodin C, Foil DH, Zhou H, Postnikova E, Liang JY, Holbrook MR, Madrid PB, Ekins S. Lane TR, et al. Antiviral Res. 2020 Oct;182:104908. doi: 10.1016/j.antiviral.2020.104908. Epub 2020 Aug 13. Antiviral Res. 2020. PMID: 32798602 Free PMC article.
We have recently identified three molecules (tilorone, quinacrine and pyronaridine tetraphosphate) which all demonstrated efficacy in the mouse model of infection with mouse-adapted Ebola virus (EBOV) model of disease and had similar in vitro inhibition of an Ebola pseudov …
We have recently identified three molecules (tilorone, quinacrine and pyronaridine tetraphosphate) which all demonstrated efficacy in …
Tilorone activates NK cells and cytotoxic lymphocytes that kill HLA-negative tumor cells.
Sharapova TN, Romanova EA, Sashchenko LP, Yashin DV. Sharapova TN, et al. IUBMB Life. 2019 Mar;71(3):376-384. doi: 10.1002/iub.1985. Epub 2018 Dec 11. IUBMB Life. 2019. PMID: 30537230 Free article.
Tilorone hydrochloride, a low-molecular-weight synthetic compound, induces interferon production and has been reported to have both antiviral and antitumor activities. Here, we have demonstrated the ability of tilorone to activate NK cells and specific subpopulation …
Tilorone hydrochloride, a low-molecular-weight synthetic compound, induces interferon production and has been reported to have both a …
Pulmonary administration of a dry powder formulation of the antifibrotic drug tilorone reduces silica-induced lung fibrosis in mice.
Vartiainen V, Raula J, Bimbo LM, Viinamäki J, Backman JT, Ugur N, Kauppinen E, Sutinen E, Joensuu E, Koli K, Myllärniemi M. Vartiainen V, et al. Int J Pharm. 2018 Jun 10;544(1):121-128. doi: 10.1016/j.ijpharm.2018.04.019. Epub 2018 Apr 12. Int J Pharm. 2018. PMID: 29655797 Free article.
The aim of this work was to study the antifibrotic effect of pulmonary administration of tilorone to lung fibrosis. L-leucine coated tilorone particles were prepared and their aerosolization properties were analyzed using two dry powder inhalers (Easyhaler and Twist …
The aim of this work was to study the antifibrotic effect of pulmonary administration of tilorone to lung fibrosis. L-leucine coated …
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