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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1970 3
1971 4
1972 10
1973 8
1974 13
1975 15
1976 28
1977 43
1978 19
1979 24
1980 21
1981 21
1982 8
1983 15
1984 16
1985 15
1986 13
1987 6
1988 10
1989 6
1990 9
1991 10
1992 6
1993 2
1994 4
1995 6
1996 9
1997 3
1998 6
1999 1
2000 6
2001 7
2002 8
2003 1
2004 4
2005 5
2006 4
2007 7
2008 9
2009 1
2010 3
2011 4
2012 6
2013 8
2014 2
2015 3
2016 3
2017 1
2018 5
2019 6
2020 12
2021 7
2022 4
2023 0
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463 results
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Page 1
Tilorone hydrochloride: the drug profile.
Chandra P, Wright GJ. Chandra P, et al. Top Curr Chem. 1977;72:125-48. doi: 10.1007/BFb0048451. Top Curr Chem. 1977. PMID: 339405 Review. No abstract available.
Tilorone, a Broad-Spectrum Antiviral for Emerging Viruses.
Ekins S, Madrid PB. Ekins S, et al. Antimicrob Agents Chemother. 2020 Apr 21;64(5):e00440-20. doi: 10.1128/AAC.00440-20. Print 2020 Apr 21. Antimicrob Agents Chemother. 2020. PMID: 32205350 Free PMC article.
Tilorone is a 50-year-old synthetic small-molecule compound with antiviral activity that is proposed to induce interferon after oral administration. ...
Tilorone is a 50-year-old synthetic small-molecule compound with antiviral activity that is proposed to induce interferon after oral …
Tilorone-Dihydrochloride Protects against Rift Valley Fever Virus Infection and Disease in the Mouse Model.
Johnson KN, Kalveram B, Smith JK, Zhang L, Juelich T, Atkins C, Ikegami T, Freiberg AN. Johnson KN, et al. Microorganisms. 2021 Dec 31;10(1):92. doi: 10.3390/microorganisms10010092. Microorganisms. 2021. PMID: 35056541 Free PMC article.
Here, we evaluated the antiviral activity of Tilorone against Rift Valley fever virus (RVFV). In vitro, Tilorone inhibited both vaccine (MP-12) and virulent (ZH501) strains of RVFV at low micromolar concentrations. ...These findings demonstrate that Tilorone …
Here, we evaluated the antiviral activity of Tilorone against Rift Valley fever virus (RVFV). In vitro, Tilorone inhibited bot …
Tilorone confers robust in vitro and in vivo antiviral effects against severe fever with thrombocytopenia syndrome virus.
Yang J, Yan Y, Dai Q, Yin J, Zhao L, Li Y, Li W, Zhong W, Cao R, Li S. Yang J, et al. Virol Sin. 2022 Feb;37(1):145-148. doi: 10.1016/j.virs.2022.01.014. Epub 2022 Jan 18. Virol Sin. 2022. PMID: 35234618 Free PMC article.
Tilorone dihydrochloride possesses robust anti-SFTSV activity in vitro and in vivo. ...The anti-SFTSV mechanism of tilorone is through stimulation of host innate immunity. Pre-treatment with tilorone can prevent mice from lethal SFTSV challenge....
Tilorone dihydrochloride possesses robust anti-SFTSV activity in vitro and in vivo. ...The anti-SFTSV mechanism of tilorone is …
Tilorone and Cridanimod Protect Mice and Show Antiviral Activity in Rats despite Absence of the Interferon-Inducing Effect in Rats.
Keyer V, Syzdykova L, Zauatbayeva G, Zhulikeyeva A, Ramanculov Y, Shustov AV, Shulgau Z. Keyer V, et al. Pharmaceuticals (Basel). 2022 May 17;15(5):617. doi: 10.3390/ph15050617. Pharmaceuticals (Basel). 2022. PMID: 35631443 Free PMC article.
The synthetic compounds, Tilorone and Cridanimod, have the antiviral activity which initially had been ascribed to the capacity to induce interferon. ...Tilorone and Cridanimod show the antiviral activity in mice and rats and protect the mice from death. ...
The synthetic compounds, Tilorone and Cridanimod, have the antiviral activity which initially had been ascribed to the capacity to in …
The Antiviral Drug Tilorone Is a Potent and Selective Inhibitor of Acetylcholinesterase.
Vignaux PA, Minerali E, Lane TR, Foil DH, Madrid PB, Puhl AC, Ekins S. Vignaux PA, et al. Chem Res Toxicol. 2021 May 17;34(5):1296-1307. doi: 10.1021/acs.chemrestox.0c00466. Epub 2021 Jan 5. Chem Res Toxicol. 2021. PMID: 33400519 Free PMC article.
We have described how tilorone inhibits both eel and human AChE with IC(50)'s of 14.4 nM and 64.4 nM, respectively, but does not inhibit the closely related BuChE IC(50) > 50 muM. ...This study suggests there may be a potential role for repurposing tilorone or it …
We have described how tilorone inhibits both eel and human AChE with IC(50)'s of 14.4 nM and 64.4 nM, respectively, but does not inhi …
Tilorone: a Broad-Spectrum Antiviral Invented in the USA and Commercialized in Russia and beyond.
Ekins S, Lane TR, Madrid PB. Ekins S, et al. Pharm Res. 2020 Mar 25;37(4):71. doi: 10.1007/s11095-020-02799-8. Pharm Res. 2020. PMID: 32215760 Free PMC article.
For the last 50 years we have known of a broad-spectrum agent tilorone dihydrochloride (Tilorone). This is a small-molecule orally bioavailable drug that was originally discovered in the USA and is currently used clinically as an antiviral in Russia and the Ukraine. …
For the last 50 years we have known of a broad-spectrum agent tilorone dihydrochloride (Tilorone). This is a small-molecule or …
Efficacy of Tilorone Dihydrochloride against Ebola Virus Infection.
Ekins S, Lingerfelt MA, Comer JE, Freiberg AN, Mirsalis JC, O'Loughlin K, Harutyunyan A, McFarlane C, Green CE, Madrid PB. Ekins S, et al. Antimicrob Agents Chemother. 2018 Jan 25;62(2):e01711-17. doi: 10.1128/AAC.01711-17. Print 2018 Feb. Antimicrob Agents Chemother. 2018. PMID: 29133569 Free PMC article.
Tilorone dihydrochloride (tilorone) is a small-molecule, orally bioavailable drug that is used clinically as an antiviral outside the United States. A machine-learning model trained on anti-Ebola virus (EBOV) screening data previously identified tilorone as a …
Tilorone dihydrochloride (tilorone) is a small-molecule, orally bioavailable drug that is used clinically as an antiviral outs …
Tilorone activates NK cells and cytotoxic lymphocytes that kill HLA-negative tumor cells.
Sharapova TN, Romanova EA, Sashchenko LP, Yashin DV. Sharapova TN, et al. IUBMB Life. 2019 Mar;71(3):376-384. doi: 10.1002/iub.1985. Epub 2018 Dec 11. IUBMB Life. 2019. PMID: 30537230 Free article.
Tilorone hydrochloride, a low-molecular-weight synthetic compound, induces interferon production and has been reported to have both antiviral and antitumor activities. Here, we have demonstrated the ability of tilorone to activate NK cells and specific subpopulation …
Tilorone hydrochloride, a low-molecular-weight synthetic compound, induces interferon production and has been reported to have both a …
463 results