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brlA is necessary and sufficient to direct conidiophore development in Aspergillus nidulans.
Adams TH, Boylan MT, Timberlake WE. Adams TH, et al. Cell. 1988 Jul 29;54(3):353-62. doi: 10.1016/0092-8674(88)90198-5. Cell. 1988. PMID: 3293800
We propose that BRLA is a nucleic acid-binding protein whose expression in vegetative cells is sufficient to induce sporulation through its role in regulating expression of conidiation-specific genes....
We propose that BRLA is a nucleic acid-binding protein whose expression in vegetative cells is sufficient to induce sporulation throu
Developmental regulation of laccase levels in Aspergillus nidulans.
Law DJ, Timberlake WE. Law DJ, et al. J Bacteriol. 1980 Nov;144(2):509-17. doi: 10.1128/JB.144.2.509-517.1980. J Bacteriol. 1980. PMID: 7000747 Free PMC article.
We have investigated the mechanisms regulating expression of the gamma A gene of A. nidulans. Vegetative hyphae grown in submerged culture lacked detectable laccase enzyme activity and neither contained nor synthesized immunoprecipitable laccase protein. ...
We have investigated the mechanisms regulating expression of the gamma A gene of A. nidulans. Vegetative hyphae grown in submerged cu
Developmental gene regulation in Aspergillus nidulans.
Timberlake WE. Timberlake WE. Dev Biol. 1980 Aug;78(2):497-510. doi: 10.1016/0012-1606(80)90349-8. Dev Biol. 1980. PMID: 6997115 No abstract available.
The Aspergillus nidulans abaA gene encodes a transcriptional activator that acts as a genetic switch to control development.
Andrianopoulos A, Timberlake WE. Andrianopoulos A, et al. Mol Cell Biol. 1994 Apr;14(4):2503-15. doi: 10.1128/mcb.14.4.2503. Mol Cell Biol. 1994. PMID: 8139553 Free PMC article.
From these observations, we propose that the AbaA transcription factor establishes a novel set of feedback regulatory loops responsible for determination of conidiophore development....
From these observations, we propose that the AbaA transcription factor establishes a novel set of feedback regulatory loops responsib …
Cerato-ulmin, a toxin involved in Dutch elm disease, is a fungal hydrophobin.
Stringer MA, Timberlake WE. Stringer MA, et al. Plant Cell. 1993 Feb;5(2):145-6. doi: 10.1105/tpc.5.2.145. Plant Cell. 1993. PMID: 8453298 Free PMC article. No abstract available.
ATTS, a new and conserved DNA binding domain.
Andrianopoulos A, Timberlake WE. Andrianopoulos A, et al. Plant Cell. 1991 Aug;3(8):747-8. doi: 10.1105/tpc.3.8.747. Plant Cell. 1991. PMID: 1820817 Free PMC article. No abstract available.
Sequence complexity of nuclear and polysomal RNA in leaves of the tobacco plant.
Goldberg RB, Hoschek G, Kamalay JC, Timberlake WE. Goldberg RB, et al. Cell. 1978 May;14(1):123-31. doi: 10.1016/0092-8674(78)90307-0. Cell. 1978. PMID: 667929
Chromosome-specific recombinant DNA libraries from the fungus Aspergillus nidulans.
Brody H, Griffith J, Cuticchia AJ, Arnold J, Timberlake WE. Brody H, et al. Nucleic Acids Res. 1991 Jun 11;19(11):3105-9. doi: 10.1093/nar/19.11.3105. Nucleic Acids Res. 1991. PMID: 2057366 Free PMC article.
To simplify the analysis required to determine which clones in a genomic library overlap one another, we partitioned Aspergillus nidulans cosmid libraries into chromosome-specific subcollections. ...
To simplify the analysis required to determine which clones in a genomic library overlap one another, we partitioned Aspergillus nidu …
CMAP: contig mapping and analysis package, a relational database for chromosome reconstruction.
Cuticchia AJ, Arnold J, Brody H, Timberlake WE. Cuticchia AJ, et al. Comput Appl Biosci. 1992 Oct;8(5):467-74. doi: 10.1093/bioinformatics/8.5.467. Comput Appl Biosci. 1992. PMID: 1422880
In the contig mapping and analysis package, CMAP, we provide a foundation for reverse genetics by organizing information about DNA fragments obtained from an organism's genome into a physical map. ...
In the contig mapping and analysis package, CMAP, we provide a foundation for reverse genetics by organizing information about DNA fr …
The use of simulated annealing in chromosome reconstruction experiments based on binary scoring.
Cuticchia AJ, Arnold J, Timberlake WE. Cuticchia AJ, et al. Genetics. 1992 Oct;132(2):591-601. Genetics. 1992. PMID: 1427046 Free PMC article.
We present a method of combinatorial optimization, simulated annealing, to order clones in a library with respect to their position along a chromosome. ...Specifically, we consider the hybridization of oligonucleotide probes to a clone to constitute the signature. I
We present a method of combinatorial optimization, simulated annealing, to order clones in a library with respect to their position a
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