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Nuclear cGAS suppresses DNA repair and promotes tumorigenesis.
Liu H, Zhang H, Wu X, Ma D, Wu J, Wang L, Jiang Y, Fei Y, Zhu C, Tan R, Jungblut P, Pei G, Dorhoi A, Yan Q, Zhang F, Zheng R, Liu S, Liang H, Liu Z, Yang H, Chen J, Wang P, Tang T, Peng W, Hu Z, Xu Z, Huang X, Wang J, Li H, Zhou Y, Liu F, Yan D, Kaufmann SHE, Chen C, Mao Z, Ge B. Liu H, et al. Nature. 2018 Nov;563(7729):131-136. doi: 10.1038/s41586-018-0629-6. Epub 2018 Oct 24. Nature. 2018. PMID: 30356214
Accurate repair of DNA double-stranded breaks by homologous recombination preserves genome integrity and inhibits tumorigenesis. ...In the nucleus, cGAS is recruited to double-stranded breaks and interacts with PARP1 via poly(ADP-ribose). The cG …
Accurate repair of DNA double-stranded breaks by homologous recombination preserves genome integrity and inhibit …
Timeless Interacts with PARP-1 to Promote Homologous Recombination Repair.
Xie S, Mortusewicz O, Ma HT, Herr P, Poon RY, Helleday T, Qian C. Xie S, et al. Mol Cell. 2015 Oct 1;60(1):163-76. doi: 10.1016/j.molcel.2015.07.031. Epub 2015 Sep 3. Mol Cell. 2015. PMID: 26344098 Free article.
However, it remains elusive whether Timeless is involved in the repair of damaged DNA. Here, we identify that Timeless physically interacts with PARP-1 independent of poly(ADP-ribosyl)ation. ...Furthermore, we show that Timeless …
However, it remains elusive whether Timeless is involved in the repair of damaged DNA. Here, we identify that Timele …