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Tizanidine.
[No authors listed] [No authors listed] 2017 Jan 30. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. 2017 Jan 30. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. PMID: 31643379 Free Books & Documents. Review.
Tizanidine is a commonly used muscle relaxant that has been linked to rare instances of acute liver injury, a few of which have been fatal....
Tizanidine is a commonly used muscle relaxant that has been linked to rare instances of acute liver injury, a few of which have been …
Tizanidine: Advances in Pharmacology & Therapeutics and Drug Formulations.
Zhu LL, Wang YH, Zhou Q. Zhu LL, et al. J Pain Res. 2024 Mar 21;17:1257-1271. doi: 10.2147/JPR.S461032. eCollection 2024. J Pain Res. 2024. PMID: 38529017 Free PMC article. Review.
In our geriatric practice, off-label use of tizanidine as preemptive analgesia drove us to find recent advances in its pharmacology and therapeutics. ...CONCLUSION: Tizanidine is an SMR with unique features and may be an optimal initial choice for older adults. ...
In our geriatric practice, off-label use of tizanidine as preemptive analgesia drove us to find recent advances in its pharmacology a …
Tizanidine.
Ghanavatian S, Derian A. Ghanavatian S, et al. 2023 Aug 28. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–. 2023 Aug 28. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–. PMID: 30137790 Free Books & Documents.
Tizanidine is an FDA-approved drug for managing spasticity. It is a centrally acting alpha-2 receptor agonist. Tizanidine effectively works with spasticity caused by multiple sclerosis, an acquired brain injury, or a spinal cord injury. ...
Tizanidine is an FDA-approved drug for managing spasticity. It is a centrally acting alpha-2 receptor agonist. Tizanidine effe …
Tizanidine Induced Hypotension: Report of a Case and Review of the Literature.
Mahajan R, Kalita J. Mahajan R, et al. Curr Drug Saf. 2024;19(2):313-316. doi: 10.2174/1574886318666230725113855. Curr Drug Saf. 2024. PMID: 37489780 Review.
He was on amlodipine, atenolol, telmisartan and oxcarbazepine. After 3 doses of tizanidine 2mg, his blood pressure dropped from 140/90 to 80/40 mmHg and pulse from 82 bpm to 44 bpm. ...ECG revealed sinus bradycardia. After 8 hours of withdrawing tizanidine, his bloo …
He was on amlodipine, atenolol, telmisartan and oxcarbazepine. After 3 doses of tizanidine 2mg, his blood pressure dropped from 140/9 …
Tizanidine: neuropharmacology and mechanism of action.
Coward DM. Coward DM. Neurology. 1994 Nov;44(11 Suppl 9):S6-10; discussion S10-1. Neurology. 1994. PMID: 7970012 Review.
Pharmacologic and electrophysiologic studies over the past 20 years have shown tizanidine to be a potent, central-acting myotonolytic agent that principally affects spinal polysynaptic reflexes. ...Similar alpha 2-receptor-mediated inhibition of interneuronal activity appe …
Pharmacologic and electrophysiologic studies over the past 20 years have shown tizanidine to be a potent, central-acting myotonolytic …
Efficacy and safety of oral tizanidine premedication as pre-emptive analgesia in adult patients undergoing elective surgeries- A systematic review.
Nair A, Rangaiah M, Borkar N. Nair A, et al. Saudi J Anaesth. 2023 Apr-Jun;17(2):214-222. doi: 10.4103/sja.sja_780_22. Epub 2023 Mar 10. Saudi J Anaesth. 2023. PMID: 37260650 Free PMC article. Review.
Tizanidine is a centrally acting alpha2 agonist which has been used as a premedication due to its opioid-sparing and sympatholytic properties. ...Tizanidine reduces intraoperative opioid consumption without significant adverse events. ...
Tizanidine is a centrally acting alpha2 agonist which has been used as a premedication due to its opioid-sparing and sympatholytic pr …
Baclofen and Tizanidine Adverse Effects Observed Among Community-Dwelling Adults Above the Age of 50 Years: A Systematic Review.
Killam-Worrall L, Brand R, Castro JR, Patel DS, Huynh K, Lindley B, Torres BP. Killam-Worrall L, et al. Ann Pharmacother. 2024 May;58(5):523-532. doi: 10.1177/10600280231193080. Epub 2023 Aug 17. Ann Pharmacother. 2024. PMID: 37589096
OBJECTIVE: This review highlights adverse effects of baclofen and tizanidine in older community-dwelling adults. DATA SOURCES: A literature search was conducted, including search terms of "adverse effect," "baclofen," "elderly," "falls," "fractures," and "tizanidine …
OBJECTIVE: This review highlights adverse effects of baclofen and tizanidine in older community-dwelling adults. DATA SOURCES: A lite …
Tizanidine in Postmortem Forensic Cases.
Friederich L, Mata D, Bishop-Freeman S. Friederich L, et al. J Anal Toxicol. 2025 Jun 17:bkaf056. doi: 10.1093/jat/bkaf056. Online ahead of print. J Anal Toxicol. 2025. PMID: 40574679
Tizanidine therapeutic concentrations found in plasma are reported in the range of 0.0025-0.025 mg/L, although CYP1A2 inhibitors can significantly raise tizanidine levels in the body, thereby increasing the risk of dose-related toxicity. ...In this study, 18 postmor …
Tizanidine therapeutic concentrations found in plasma are reported in the range of 0.0025-0.025 mg/L, although CYP1A2 inhibitors can …
Pediatric tizanidine toxicity reversed with naloxone: a case report.
Bader D, Adam A, Shaban M, Alyahya B. Bader D, et al. Int J Emerg Med. 2021 Dec 14;14(1):73. doi: 10.1186/s12245-021-00397-y. Int J Emerg Med. 2021. PMID: 34906071 Free PMC article.
BACKGROUND: Tizanidine, an alpha-2 adrenoceptor agonist, is widely prescribed for the management of spasticity in adults. Case reports on pediatric tizanidine overdose are limited. Here, we report a case of pediatric tizanidine toxicity that was reversed with …
BACKGROUND: Tizanidine, an alpha-2 adrenoceptor agonist, is widely prescribed for the management of spasticity in adults. Case report …
Tizanidine. A review of its pharmacology, clinical efficacy and tolerability in the management of spasticity associated with cerebral and spinal disorders.
Wagstaff AJ, Bryson HM. Wagstaff AJ, et al. Drugs. 1997 Mar;53(3):435-52. doi: 10.2165/00003495-199753030-00007. Drugs. 1997. PMID: 9074844 Review.
Spasm frequency and clonus are also reduced by tizanidine. The most common adverse effects associated with tizanidine are dry mouth and somnolence/drowsiness. Muscle strength, as assessed by objective means, appears not to be adversely affected by tizanidine …
Spasm frequency and clonus are also reduced by tizanidine. The most common adverse effects associated with tizanidine are dry …
694 results