Abstract
Influence of retinoid C17-diester retinyldimedone and L-tocopherylretinoate on the growth of transplanted tumors was investigated in F1 (C57Bl/6 X CBA) strain of mice. The retinoids studied proved to be less toxic than retinoic acid. Both retinoid C17-diester and L-tocopherylretinoate reduced growth of cervical cancer, while retinyldimedone inhibited growth of Lewis carcinoma (lung tumor) and of stomach carcinoma.
MeSH terms
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Animals
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Cell Division / drug effects
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Chemical Phenomena
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Chemistry
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Female
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Male
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Mice
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Neoplasms, Experimental / pathology*
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Retinoids / pharmacology*
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Retinoids / toxicity
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Tretinoin / analogs & derivatives
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Tretinoin / pharmacology
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Tretinoin / toxicity
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Vitamin E / analogs & derivatives
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Vitamin E / pharmacology
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Vitamin E / toxicity
Substances
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Retinoids
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tocopheryl retinoate
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5-methyl-7-(2,6-dimethyl-6-ethoxycarbonyl-3-oxo-1-cyclohexyl)-2,4,6-heptatrienoic acid
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Vitamin E
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Tretinoin
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retinylidene dimedone