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Antagonists of the human A(2A) adenosine receptor. 4. Design, synthesis, and preclinical evaluation of 7-aryltriazolo[4,5-d]pyrimidines.
Gillespie RJ, Bamford SJ, Botting R, Comer M, Denny S, Gaur S, Griffin M, Jordan AM, Knight AR, Lerpiniere J, Leonardi S, Lightowler S, McAteer S, Merrett A, Misra A, Padfield A, Reece M, Saadi M, Selwood DL, Stratton GC, Surry D, Todd R, Tong X, Ruston V, Upton R, Weiss SM. Gillespie RJ, et al. Among authors: todd r. J Med Chem. 2009 Jan 8;52(1):33-47. doi: 10.1021/jm800961g. J Med Chem. 2009. PMID: 19072055
Antagonists of the human adenosine A2A receptor. Part 2: Design and synthesis of 4-arylthieno[3,2-d]pyrimidine derivatives.
Gillespie RJ, Cliffe IA, Dawson CE, Dourish CT, Gaur S, Giles PR, Jordan AM, Knight AR, Lawrence A, Lerpiniere J, Misra A, Pratt RM, Todd RS, Upton R, Weiss SM, Williamson DS. Gillespie RJ, et al. Among authors: todd rs. Bioorg Med Chem Lett. 2008 May 1;18(9):2920-3. doi: 10.1016/j.bmcl.2008.03.076. Epub 2008 Mar 30. Bioorg Med Chem Lett. 2008. PMID: 18407496
Asymmetric synthesis of BB-3497--a potent peptide deformylase inhibitor.
Pratt LM, Beckett RP, Davies SJ, Launchbury SB, Miller A, Spavold ZM, Todd RS, Whittaker M. Pratt LM, et al. Among authors: todd rs. Bioorg Med Chem Lett. 2001 Oct 8;11(19):2585-8. doi: 10.1016/s0960-894x(01)00509-1. Bioorg Med Chem Lett. 2001. PMID: 11551755
Structure-activity relationships of the peptide deformylase inhibitor BB-3497: modification of the methylene spacer and the P1' side chain.
Davies SJ, Ayscough AP, Beckett RP, Bragg RA, Clements JM, Doel S, Grew C, Launchbury SB, Perkins GM, Pratt LM, Smith HK, Spavold ZM, Thomas SW, Todd RS, Whittaker M. Davies SJ, et al. Among authors: todd rs. Bioorg Med Chem Lett. 2003 Aug 18;13(16):2709-13. doi: 10.1016/s0960-894x(03)00532-8. Bioorg Med Chem Lett. 2003. PMID: 12873499
Peptide deformylase inhibitors with activity against respiratory tract pathogens.
East SP, Beckett RP, Brookings DC, Clements JM, Doel S, Keavey K, Pain G, Smith HK, Thomas W, Thompson AJ, Todd RS, Whittaker M. East SP, et al. Among authors: todd rs. Bioorg Med Chem Lett. 2004 Jan 5;14(1):59-62. doi: 10.1016/j.bmcl.2003.10.013. Bioorg Med Chem Lett. 2004. PMID: 14684298
880 results