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Hedgehog beyond medulloblastoma and basal cell carcinoma.
Teglund S, Toftgård R. Teglund S, et al. Biochim Biophys Acta. 2010 Apr;1805(2):181-208. doi: 10.1016/j.bbcan.2010.01.003. Epub 2010 Jan 18. Biochim Biophys Acta. 2010. PMID: 20085802 Review.
Hedgehog signaling and pancreatic tumor development.
Lauth M, Toftgård R. Lauth M, et al. Adv Cancer Res. 2011;110:1-17. doi: 10.1016/B978-0-12-386469-7.00001-3. Adv Cancer Res. 2011. PMID: 21704226 Review.
Differential requirement of SUFU in tissue development discovered in a hypomorphic mouse model.
Hoelzl MA, Heby-Henricson K, Gerling M, Dias JM, Kuiper RV, Trünkle C, Bergström Å, Ericson J, Toftgård R, Teglund S. Hoelzl MA, et al. Among authors: toftgard r. Dev Biol. 2017 Sep 1;429(1):132-146. doi: 10.1016/j.ydbio.2017.06.037. Epub 2017 Jul 5. Dev Biol. 2017. PMID: 28688895 Free PMC article.
SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development.
Raducu M, Fung E, Serres S, Infante P, Barberis A, Fischer R, Bristow C, Thézénas ML, Finta C, Christianson JC, Buffa FM, Kessler BM, Sibson NR, Di Marcotullio L, Toftgård R, D'Angiolella V. Raducu M, et al. Among authors: toftgard r. EMBO J. 2016 Jul 1;35(13):1400-16. doi: 10.15252/embj.201593374. Epub 2016 May 27. EMBO J. 2016. PMID: 27234298 Free PMC article.
Suppressor of Fused inhibits mammalian Hedgehog signaling in the absence of cilia.
Jia J, Kolterud A, Zeng H, Hoover A, Teglund S, Toftgård R, Liu A. Jia J, et al. Dev Biol. 2009 Jun 15;330(2):452-60. doi: 10.1016/j.ydbio.2009.04.009. Epub 2009 Apr 14. Dev Biol. 2009. PMID: 19371734 Free PMC article.
A conditional transgenic mouse line for targeted expression of the stem cell marker LGR5.
Norum JH, Bergström Å, Andersson AB, Kuiper RV, Hoelzl MA, Sørlie T, Toftgård R. Norum JH, et al. Dev Biol. 2015 Aug 15;404(2):35-48. doi: 10.1016/j.ydbio.2015.05.002. Epub 2015 May 21. Dev Biol. 2015. PMID: 26003047
The hair follicle-a stem cell zoo.
Jaks V, Kasper M, Toftgård R. Jaks V, et al. Exp Cell Res. 2010 May 1;316(8):1422-8. doi: 10.1016/j.yexcr.2010.03.014. Epub 2010 Mar 23. Exp Cell Res. 2010. PMID: 20338163 Review.
Regulated splicing of the α6 integrin cytoplasmic domain determines the fate of breast cancer stem cells.
Goel HL, Gritsko T, Pursell B, Chang C, Shultz LD, Greiner DL, Norum JH, Toftgard R, Shaw LM, Mercurio AM. Goel HL, et al. Cell Rep. 2014 May 8;7(3):747-61. doi: 10.1016/j.celrep.2014.03.059. Epub 2014 Apr 24. Cell Rep. 2014. PMID: 24767994 Free PMC article.
DYRK1B-dependent autocrine-to-paracrine shift of Hedgehog signaling by mutant RAS.
Lauth M, Bergström A, Shimokawa T, Tostar U, Jin Q, Fendrich V, Guerra C, Barbacid M, Toftgård R. Lauth M, et al. Nat Struct Mol Biol. 2010 Jun;17(6):718-25. doi: 10.1038/nsmb.1833. Epub 2010 May 30. Nat Struct Mol Biol. 2010. PMID: 20512148
Two sides to cilia in cancer.
Toftgård R. Toftgård R. Nat Med. 2009 Sep;15(9):994-6. doi: 10.1038/nm0909-994. Nat Med. 2009. PMID: 19734870 No abstract available.
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