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Airway hyperresponsiveness in asthma: a problem of limited smooth muscle relaxation with inspiration.
Skloot G, Permutt S, Togias A. Skloot G, et al. Among authors: togias a. J Clin Invest. 1995 Nov;96(5):2393-403. doi: 10.1172/JCI118296. J Clin Invest. 1995. PMID: 7593627 Free PMC article. Clinical Trial.
If the hypothesis was correct, we reasoned that the sensitivity to inhaled methacholine in normal and asthmatic subjects should be the same if the challenge was carried out under conditions where deep inspirations were prohibited. 10 asthmatic and 10 normal subjects received incr …
If the hypothesis was correct, we reasoned that the sensitivity to inhaled methacholine in normal and asthmatic subjects should be the same …
Dose-dependent effects of capsaicin nasal challenge: in vivo evidence of human airway neurogenic inflammation.
Sanico AM, Atsuta S, Proud D, Togias A. Sanico AM, et al. Among authors: togias a. J Allergy Clin Immunol. 1997 Nov;100(5):632-41. doi: 10.1016/s0091-6749(97)70167-2. J Allergy Clin Immunol. 1997. PMID: 9389293 Clinical Trial.
Capsaicin, the pungent component of hot pepper that specifically stimulates afferent nerve fibers, was administered by means of nasal spray in doses of 1 microg, 10 microg, and 100 microg in a double-blind, randomized, crossover manner with 1 week between doses. ...
Capsaicin, the pungent component of hot pepper that specifically stimulates afferent nerve fibers, was administered by means of nasal spray …
Studies on the relationships between sensitivity to cold, dry air, hyperosmolal solutions, and histamine in the adult nose.
Togias A, Lykens K, Kagey-Sobotka A, Eggleston PA, Proud D, Lichtenstein LM, Naclerio RM. Togias A, et al. Am Rev Respir Dis. 1990 Jun;141(6):1428-33. doi: 10.1164/ajrccm/141.6.1428. Am Rev Respir Dis. 1990. PMID: 2112349
These findings led to a comparison of the effect of nasal challenge with hypertonic fluid in 11 subjects who demonstrated a nasal response to CDA compared to 10 subjects without CDA sensitivity. ...Allergic status was not a factor in hyperosmolal reactivity. …
These findings led to a comparison of the effect of nasal challenge with hypertonic fluid in 11 subjects who demonstrated a na …
Studies on the allergic and nonallergic nasal inflammation.
Togias A, Naclerio RM, Proud D, Pipkorn U, Bascom R, Iliopoulos O, Kagey-Sobotka A, Norman PS, Lichtenstein LM. Togias A, et al. J Allergy Clin Immunol. 1988 May;81(5 Pt 1):782-90. doi: 10.1016/0091-6749(88)90932-3. J Allergy Clin Immunol. 1988. PMID: 3286718 Review.
An early and a late reaction are detected clinically in the nose after antigen challenge of allergic individuals. In addition, the sensitivity to antigen significantly increases after the initial challenge, and this phenomenon is not obligatorily linked to the presence of …
An early and a late reaction are detected clinically in the nose after antigen challenge of allergic individuals. In addition, the se …
Reflex activation of nasal secretion by unilateral inhalation of cold dry air.
Philip G, Jankowski R, Baroody FM, Naclerio RM, Togias AG. Philip G, et al. Among authors: togias ag. Am Rev Respir Dis. 1993 Dec;148(6 Pt 1):1616-22. doi: 10.1164/ajrccm/148.6_Pt_1.1616. Am Rev Respir Dis. 1993. PMID: 8256911
To evaluate whether this response involves a neurogenic component, we delivered a unilateral cold dry air (UniCDA) nasal challenge to volunteers with previously documented reactivity to cold dry air. ...Topical atropine (0.225 mg), a muscarinic antagonist, in …
To evaluate whether this response involves a neurogenic component, we delivered a unilateral cold dry air (UniCDA) nasal chall …
Allergen-induced hyperresponsiveness to bradykinin is more pronounced than that to methacholine.
Berman AR, Togias AG, Skloot G, Proud D. Berman AR, et al. Among authors: togias ag. J Appl Physiol (1985). 1995 May;78(5):1844-52. doi: 10.1152/jappl.1995.78.5.1844. J Appl Physiol (1985). 1995. PMID: 7649921 Clinical Trial.
Bradykinin inhalational challenge provides a sensitive index of the airway's response to allergen....
Bradykinin inhalational challenge provides a sensitive index of the airway's response to allergen....
Nonallergic rhinitis. Pathophysiology and models for study.
Philip G, Togias AG. Philip G, et al. Among authors: togias ag. Eur Arch Otorhinolaryngol. 1995;252 Suppl 1:S27-32. doi: 10.1007/BF02484431. Eur Arch Otorhinolaryngol. 1995. PMID: 7734973 Review.
Nonallergic rhinitis is a diagnosis of exclusion which is given to patients who suffer perennial nasal congestion, rhinorrhea, and/or sneezing with no identifiable allergic etiology. ...These approaches provide a certain understanding of this common but perplexing e …
Nonallergic rhinitis is a diagnosis of exclusion which is given to patients who suffer perennial nasal congestion, rhinorrhea, and/or …
Inhibition of the response to nasal provocation with bradykinin by HOE-140: efficacy and duration of action.
Proud D, Bathon JM, Togias AG, Naclerio RM. Proud D, et al. Among authors: togias ag. Can J Physiol Pharmacol. 1995 Jul;73(7):820-6. doi: 10.1139/y95-111. Can J Physiol Pharmacol. 1995. PMID: 8846415 Clinical Trial.
Bradykinin-induced symptoms and increased vascular permeability could be inhibited, in a dose-dependent manner, by preadministration of HOE-140 5 min prior to kinin challenge. ...Preadministration of HOE-140 2 h before kinin challenge caused a significant but much w …
Bradykinin-induced symptoms and increased vascular permeability could be inhibited, in a dose-dependent manner, by preadministration …
The human nasal response to capsaicin.
Philip G, Baroody FM, Proud D, Naclerio RM, Togias AG. Philip G, et al. Among authors: togias ag. J Allergy Clin Immunol. 1994 Dec;94(6 Pt 1):1035-45. doi: 10.1016/0091-6749(94)90122-8. J Allergy Clin Immunol. 1994. PMID: 7798536
Airway sensory nerves play a role in reactions to inhaled allergens, irritants, and physical stimuli. Capsaicin, the pungent principle of hot peppers, stimulates a subcategory of sensory nerves. ...Further, we have demonstrated that capsaicin stimulates a pre …
Airway sensory nerves play a role in reactions to inhaled allergens, irritants, and physical stimuli. Capsaicin, the pungent principl …
The role of leukotrienes in allergic rhinitis: a review.
Naclerio RM, Baroody FM, Togias AG. Naclerio RM, et al. Among authors: togias ag. Am Rev Respir Dis. 1991 May;143(5 Pt 2):S91-5. doi: 10.1164/ajrccm/143.5_Pt_2.S91. Am Rev Respir Dis. 1991. PMID: 2018250 Review.
Studies in which LT generation was pharmacologically reduced support a role for these mediators in allergic rhinitis. There is now a need to evaluate the more potent, recently developed, LT antagonists in rhinitis. ...
Studies in which LT generation was pharmacologically reduced support a role for these mediators in allergic rhinitis. There is now …
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