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EEA1, a tethering protein of the early sorting endosome, shows a polarized distribution in hippocampal neurons, epithelial cells, and fibroblasts.
Wilson JM, de Hoop M, Zorzi N, Toh BH, Dotti CG, Parton RG. Wilson JM, et al. Mol Biol Cell. 2000 Aug;11(8):2657-71. doi: 10.1091/mbc.11.8.2657. Mol Biol Cell. 2000. PMID: 10930461 Free PMC article.
The endosome fusion regulator early-endosomal autoantigen 1 (EEA1) is a dimer.
Callaghan J, Simonsen A, Gaullier JM, Toh BH, Stenmark H. Callaghan J, et al. Biochem J. 1999 Mar 1;338 ( Pt 2)(Pt 2):539-43. Biochem J. 1999. PMID: 10024533 Free PMC article.
Direct interaction of EEA1 with Rab5b.
Callaghan J, Nixon S, Bucci C, Toh BH, Stenmark H. Callaghan J, et al. Eur J Biochem. 1999 Oct 1;265(1):361-6. doi: 10.1046/j.1432-1327.1999.00743.x. Eur J Biochem. 1999. PMID: 10491193
EEA1 links PI(3)K function to Rab5 regulation of endosome fusion.
Simonsen A, Lippé R, Christoforidis S, Gaullier JM, Brech A, Callaghan J, Toh BH, Murphy C, Zerial M, Stenmark H. Simonsen A, et al. Nature. 1998 Jul 30;394(6692):494-8. doi: 10.1038/28879. Nature. 1998. PMID: 9697774
Endosomal localization of the autoantigen EEA1 is mediated by a zinc-binding FYVE finger.
Stenmark H, Aasland R, Toh BH, D'Arrigo A. Stenmark H, et al. J Biol Chem. 1996 Sep 27;271(39):24048-54. doi: 10.1074/jbc.271.39.24048. J Biol Chem. 1996. PMID: 8798641
., and Toh, B. H. (1995) J. Biol. Chem. 270, 13503-13511). Here we show that this motif constitutes a genuine zinc binding domain, which we term the FYVE finger (based on the first letters of four proteins containing this motif). ...
., and Toh, B. H. (1995) J. Biol. Chem. 270, 13503-13511). Here we show that this motif constitutes a genuine zinc binding domain, wh …
TGF-beta and cancer: is Smad3 a repressor of hTERT gene?
Li H, Xu D, Toh BH, Liu JP. Li H, et al. Cell Res. 2006 Feb;16(2):169-73. doi: 10.1038/sj.cr.7310023. Cell Res. 2006. PMID: 16474430 Review.
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