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The plasmodial apicoplast was retained under evolutionary selective pressure to assuage blood stage oxidative stress.
Toler S. Toler S. Med Hypotheses. 2005;65(4):683-90. doi: 10.1016/j.mehy.2005.05.011. Med Hypotheses. 2005. PMID: 15996831
As Plasmodia's ancient ancestor evolved from a mixotroph to an intracellular parasite, subsiding on amino acids obtained from hemoglobin, it encountered increased oxidative stress. ...
As Plasmodia's ancient ancestor evolved from a mixotroph to an intracellular parasite, subsiding on amino acids obtained from hemoglo …
Anticholinergic therapy for overactive bladder: a nicotinic modality?
Toler SM, Yohannes D, Lippiello PM, Chancellor MB. Toler SM, et al. Med Hypotheses. 2013 Sep;81(3):456-8. doi: 10.1016/j.mehy.2013.06.008. Epub 2013 Jul 5. Med Hypotheses. 2013. PMID: 23834857
Selective enhancement of cellular oxidative stress by chloroquine: implications for the treatment of glioblastoma multiforme.
Toler SM, Noe D, Sharma A. Toler SM, et al. Neurosurg Focus. 2006 Dec 15;21(6):E10. doi: 10.3171/foc.2006.21.6.1. Neurosurg Focus. 2006. PMID: 17341043
Oxidative stress plays an important role in the pathogenesis of drug-induced retinopathy.
Toler SM. Toler SM. Exp Biol Med (Maywood). 2004 Jul;229(7):607-15. doi: 10.1177/153537020422900704. Exp Biol Med (Maywood). 2004. PMID: 15229354 Review.
Little is known of the mechanism(s) that produce these injuries. Mechanisms proposed thus far have not been embraced by the medical and scientific communities. ...
Little is known of the mechanism(s) that produce these injuries. Mechanisms proposed thus far have not been embraced by the medical a …
Invited review: fluphenazine augments retinal oxidative stress.
Toler SM. Toler SM. J Ocul Pharmacol Ther. 2005 Aug;21(4):259-65. doi: 10.1089/jop.2005.21.259. J Ocul Pharmacol Ther. 2005. PMID: 16117689 Review.
Clinical Efficacy and Tolerability of the Nicotinic Channel Modulator Dexmecamylamine in Subjects with Overactive Bladder.
Chancellor M, Versi E, Dvergsten C, Toler S. Chancellor M, et al. Among authors: toler s. J Urol. 2015 Nov;194(5):1329-35. doi: 10.1016/j.juro.2015.06.035. Epub 2015 Jun 12. J Urol. 2015. PMID: 26073872 Clinical Trial.
Not all sulfa drugs are created equal.
Toler SM, Rodriguez I. Toler SM, et al. Ann Pharmacother. 2004 Dec;38(12):2166-7. doi: 10.1345/aph.1E206. Epub 2004 Oct 19. Ann Pharmacother. 2004. PMID: 15494382 Review. No abstract available.
Pyrazolinone-piperidine dipeptide growth hormone secretagogues (GHSs). Discovery of capromorelin.
Carpino PA, Lefker BA, Toler SM, Pan LC, Hadcock JR, Cook ER, DiBrino JN, Campeta AM, DeNinno SL, Chidsey-Frink KL, Hada WA, Inthavongsay J, Mangano FM, Mullins MA, Nickerson DF, Ng O, Pirie CM, Ragan JA, Rose CR, Tess DA, Wright AS, Yu L, Zawistoski MP, DaSilva-Jardine PA, Wilson TC, Thompson DD. Carpino PA, et al. Among authors: toler sm. Bioorg Med Chem. 2003 Feb 20;11(4):581-90. doi: 10.1016/s0968-0896(02)00433-9. Bioorg Med Chem. 2003. PMID: 12538023
Creatine is an ergogen for anaerobic exercise.
Toler SM. Toler SM. Nutr Rev. 1997 Jan;55(1 Pt 1):21-3. doi: 10.1111/j.1753-4887.1997.tb06117.x. Nutr Rev. 1997. PMID: 9155214 Review.
Discovery and biological characterization of capromorelin analogues with extended half-lives.
Carpino PA, Lefker BA, Toler SM, Pan LC, Hadcock JR, Murray MC, Cook ER, DiBrino JN, DeNinno SL, Chidsey-Frink KL, Hada WA, Inthavongsay J, Lewis SK, Mangano FM, Mullins MA, Nickerson DF, Ng O, Pirie CM, Ragan JA, Rose CR, Tess DA, Wright AS, Yu L, Zawistoski MP, Pettersen JC, DaSilva-Jardine PA, Wilson TC, Thompson DD. Carpino PA, et al. Among authors: toler sm. Bioorg Med Chem Lett. 2002 Nov 18;12(22):3279-82. doi: 10.1016/s0960-894x(02)00734-5. Bioorg Med Chem Lett. 2002. PMID: 12392732
Compounds 4c and 4d (ACD LogD values >or=2.9) displayed extended plasma elimination half-lives in dogs, primarily due to high volumes of distribution, but showed weak GH secretagogue activities in rats (ED(50)s>10 mg/kg). ...
Compounds 4c and 4d (ACD LogD values >or=2.9) displayed extended plasma elimination half-lives in dogs, primarily due to high volumes of …
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