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Impact on DNA methylation in cancer prevention and therapy by bioactive dietary components.
Li Y, Tollefsbol TO. Li Y, et al. Curr Med Chem. 2010;17(20):2141-51. doi: 10.2174/092986710791299966. Curr Med Chem. 2010. PMID: 20423306 Free PMC article. Review.
Therefore, reversal of hypermethylation-induced inactivation of key tumor suppression genes by dietary DNMT inhibitors could be an effective approach to cancer prevention and therapy. In this analysis, we focus on advances in understanding the effects of dietary polyphenol …
Therefore, reversal of hypermethylation-induced inactivation of key tumor suppression genes by dietary DNMT inhibitors could be an effective …
Activity, function, and gene regulation of the catalytic subunit of telomerase (hTERT).
Poole JC, Andrews LG, Tollefsbol TO. Poole JC, et al. Gene. 2001 May 16;269(1-2):1-12. doi: 10.1016/s0378-1119(01)00440-1. Gene. 2001. PMID: 11376932 Review.
Before the characterization of the promoter of hTERT in 1999, regulatory mechanisms suggested for this gene were limited to speculation. ...Additionally, we aim to summarize the extant knowledge of hTERT gene regulation and its role in important biological processes …
Before the characterization of the promoter of hTERT in 1999, regulatory mechanisms suggested for this gene were limited to speculati …
Mechanisms for telomerase gene control in aging cells and tumorigenesis.
Tollefsbol TO, Andrews LG. Tollefsbol TO, et al. Med Hypotheses. 2001 Jun;56(6):630-7. doi: 10.1054/mehy.2000.1241. Med Hypotheses. 2001. PMID: 11399111
Although telomerase, which maintains the ends of chromosomes, is down-regulated as cells differentiate leading to attrition of chromosomal termini and ultimate replicative senescence, it is up-regulated in most cancer cells which show no net loss of average telomere length …
Although telomerase, which maintains the ends of chromosomes, is down-regulated as cells differentiate leading to attrition of chromo …
Differential maintenance and de novo methylating activity by three DNA methyltransferases in aging and immortalized fibroblasts.
Lopatina N, Haskell JF, Andrews LG, Poole JC, Saldanha S, Tollefsbol T. Lopatina N, et al. J Cell Biochem. 2002;84(2):324-34. doi: 10.1002/jcb.10015. J Cell Biochem. 2002. PMID: 11787061
To explore potential mechanisms for this process, we analyzed the methylating activity of three DNA methyltransferases (Dnmts) in aging and immortalized WI-38 fibroblasts. ...These studies indicate that reduced genome-wide methylation in aging cells may be attributed to
To explore potential mechanisms for this process, we analyzed the methylating activity of three DNA methyltransferases (Dnmts) in agi
Telomeres, telomerase, and telomerase inhibition: clinical implications for cancer.
Ahmed A, Tollefsbol T. Ahmed A, et al. J Am Geriatr Soc. 2003 Jan;51(1):116-22. doi: 10.1034/j.1601-5215.2002.51019.x. J Am Geriatr Soc. 2003. PMID: 12534855 Review.
In this article, the contemporary literature is reviewed to explore the associations between telomerase, telomerase inhibition, and cancer. Because most cancers occur in old age, with the aging of the population, the number of people suffering from cancer is expected to
In this article, the contemporary literature is reviewed to explore the associations between telomerase, telomerase inhibition, and c …
Control mechanisms in the regulation of telomerase reverse transcriptase expression in differentiating human teratocarcinoma cells.
Lopatina NG, Poole JC, Saldanha SN, Hansen NJ, Key JS, Pita MA, Andrews LG, Tollefsbol TO. Lopatina NG, et al. Biochem Biophys Res Commun. 2003 Jul 4;306(3):650-9. doi: 10.1016/s0006-291x(03)01033-7. Biochem Biophys Res Commun. 2003. PMID: 12810068
Telomerase is active in about 90% of cancers and contributes to the immortality of cancer cells by maintaining the lengths of the ends of chromosomes. Undifferentiated embryonic human teratocarcinoma (HT) cells were found to express high levels of hTERT, the catalyt …
Telomerase is active in about 90% of cancers and contributes to the immortality of cancer cells by maintaining the lengths of the end …
Transcriptional control of the DNA methyltransferases is altered in aging and neoplastically-transformed human fibroblasts.
Casillas MA Jr, Lopatina N, Andrews LG, Tollefsbol TO. Casillas MA Jr, et al. Mol Cell Biochem. 2003 Oct;252(1-2):33-43. doi: 10.1023/a:1025548623524. Mol Cell Biochem. 2003. PMID: 14577574
To address this problem, we sought to analyze changes in gene expression, protein production and enzyme activity of the three major DNA methyltransferases (Dnmtl, 3a, and 3b) in aging and neoplastically-transformed WI-38 human fetal lung fibroblasts. ...The paradoxi
To address this problem, we sought to analyze changes in gene expression, protein production and enzyme activity of the three
Aging, cancer and nutrition: the DNA methylation connection.
Liu L, Wylie RC, Andrews LG, Tollefsbol TO. Liu L, et al. Mech Ageing Dev. 2003 Dec;124(10-12):989-98. doi: 10.1016/j.mad.2003.08.001. Mech Ageing Dev. 2003. PMID: 14659588 Review.
Recent studies have also shown that dietary factors can modulate DNA methylation and thereby contribute to aging and tumorigenesis. ...
Recent studies have also shown that dietary factors can modulate DNA methylation and thereby contribute to aging and tumorigenesis. . …
EGCG down-regulates telomerase in human breast carcinoma MCF-7 cells, leading to suppression of cell viability and induction of apoptosis.
Mittal A, Pate MS, Wylie RC, Tollefsbol TO, Katiyar SK. Mittal A, et al. Int J Oncol. 2004 Mar;24(3):703-10. Int J Oncol. 2004. PMID: 14767556
Treatment of EGCG for 48 and 72 h markedly increased the percentage of apoptotic cells (32-51%) in MCF-7 cells compared to that of non-EGCG treated cells (8-14%). ...Together, our results indicate that EGCG down-regulates telomerase in human breast carcinoma MCF-7 cells, l …
Treatment of EGCG for 48 and 72 h markedly increased the percentage of apoptotic cells (32-51%) in MCF-7 cells compared to that of no …
Telomerase, telomerase inhibition, and cancer.
Ahmed A, Tollefsbol TO. Ahmed A, et al. J Anti Aging Med. 2003;6(4):315-25. doi: 10.1089/109454503323028911. J Anti Aging Med. 2003. PMID: 15142433 Review.
Telomerase activity is directly correlated with the expression of its active catalytic component, the human telomerase reverse transcriptase (hTERT), which is believed to be controlled primarily at the level of transcription. Elucidation of the control of telomerase in agi …
Telomerase activity is directly correlated with the expression of its active catalytic component, the human telomerase reverse transcriptase …
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