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Epigenetic linkage of aging, cancer and nutrition.
Daniel M, Tollefsbol TO. Daniel M, et al. Among authors: tollefsbol to. J Exp Biol. 2015 Jan 1;218(Pt 1):59-70. doi: 10.1242/jeb.107110. J Exp Biol. 2015. PMID: 25568452 Free PMC article. Review.
Reductions in caloric intake have been shown to increase both the life- and health-span in a variety of animal models. Moreover, restriction of glucose has been demonstrated to decrease the incidence of age-related diseases such as cancer and diabetes. A diet rich i …
Reductions in caloric intake have been shown to increase both the life- and health-span in a variety of animal models. Moreover, rest …
Gene expression of carbohydrate metabolism in cellular senescence and aging.
Tollefsbol TO. Tollefsbol TO. Mol Biol Med. 1987 Oct;4(5):251-63. Mol Biol Med. 1987. PMID: 3320674 Review.
There is a general slowing of protein biosynthesis with increasing age that appears to be universal and involved in the mechanism of aging. ...Intracellular carbohydrate metabolism contributes to the synthesis of virtually all macromolecules of the cell, and the age …
There is a general slowing of protein biosynthesis with increasing age that appears to be universal and involved in the mechanism of …
Activity, function, and gene regulation of the catalytic subunit of telomerase (hTERT).
Poole JC, Andrews LG, Tollefsbol TO. Poole JC, et al. Among authors: tollefsbol to. Gene. 2001 May 16;269(1-2):1-12. doi: 10.1016/s0378-1119(01)00440-1. Gene. 2001. PMID: 11376932 Review.
Before the characterization of the promoter of hTERT in 1999, regulatory mechanisms suggested for this gene were limited to speculation. ...Additionally, we aim to summarize the extant knowledge of hTERT gene regulation and its role in important biological processes …
Before the characterization of the promoter of hTERT in 1999, regulatory mechanisms suggested for this gene were limited to speculati …
Mechanisms for telomerase gene control in aging cells and tumorigenesis.
Tollefsbol TO, Andrews LG. Tollefsbol TO, et al. Med Hypotheses. 2001 Jun;56(6):630-7. doi: 10.1054/mehy.2000.1241. Med Hypotheses. 2001. PMID: 11399111
Although telomerase, which maintains the ends of chromosomes, is down-regulated as cells differentiate leading to attrition of chromosomal termini and ultimate replicative senescence, it is up-regulated in most cancer cells which show no net loss of average telomere length …
Although telomerase, which maintains the ends of chromosomes, is down-regulated as cells differentiate leading to attrition of chromo …
Telomeres and telomerase: basic science implications for aging.
Ahmed A, Tollefsbol T. Ahmed A, et al. Among authors: tollefsbol t. J Am Geriatr Soc. 2001 Aug;49(8):1105-9. doi: 10.1046/j.1532-5415.2001.49217.x. J Am Geriatr Soc. 2001. PMID: 11555075 Review.
Many theories have been proposed to explain the aging process. However, damage to deoxyribonucleic acid (DNA) is the centerpiece of most of these. ...Does the key to "youthfulness" lie in our ability to control the expression of telomerase? We have rev …
Many theories have been proposed to explain the aging process. However, damage to deoxyribonucleic acid (DNA) is the centerpie …
Differential maintenance and de novo methylating activity by three DNA methyltransferases in aging and immortalized fibroblasts.
Lopatina N, Haskell JF, Andrews LG, Poole JC, Saldanha S, Tollefsbol T. Lopatina N, et al. Among authors: tollefsbol t. J Cell Biochem. 2002;84(2):324-34. doi: 10.1002/jcb.10015. J Cell Biochem. 2002. PMID: 11787061
To explore potential mechanisms for this process, we analyzed the methylating activity of three DNA methyltransferases (Dnmts) in aging and immortalized WI-38 fibroblasts. ...These studies indicate that reduced genome-wide methylation in aging cells may be attributed to
To explore potential mechanisms for this process, we analyzed the methylating activity of three DNA methyltransferases (Dnmts) in agi
Telomeres, telomerase, and telomerase inhibition: clinical implications for cancer.
Ahmed A, Tollefsbol T. Ahmed A, et al. Among authors: tollefsbol t. J Am Geriatr Soc. 2003 Jan;51(1):116-22. doi: 10.1034/j.1601-5215.2002.51019.x. J Am Geriatr Soc. 2003. PMID: 12534855 Review.
In this article, the contemporary literature is reviewed to explore the associations between telomerase, telomerase inhibition, and cancer. Because most cancers occur in old age, with the aging of the population, the number of people suffering from cancer is expected to
In this article, the contemporary literature is reviewed to explore the associations between telomerase, telomerase inhibition, and c …
Transcriptional control of the DNA methyltransferases is altered in aging and neoplastically-transformed human fibroblasts.
Casillas MA Jr, Lopatina N, Andrews LG, Tollefsbol TO. Casillas MA Jr, et al. Among authors: tollefsbol to. Mol Cell Biochem. 2003 Oct;252(1-2):33-43. doi: 10.1023/a:1025548623524. Mol Cell Biochem. 2003. PMID: 14577574
To address this problem, we sought to analyze changes in gene expression, protein production and enzyme activity of the three major DNA methyltransferases (Dnmtl, 3a, and 3b) in aging and neoplastically-transformed WI-38 human fetal lung fibroblasts. ...The paradoxi
To address this problem, we sought to analyze changes in gene expression, protein production and enzyme activity of the three
Aging, cancer and nutrition: the DNA methylation connection.
Liu L, Wylie RC, Andrews LG, Tollefsbol TO. Liu L, et al. Among authors: tollefsbol to. Mech Ageing Dev. 2003 Dec;124(10-12):989-98. doi: 10.1016/j.mad.2003.08.001. Mech Ageing Dev. 2003. PMID: 14659588 Review.
Recent studies have also shown that dietary factors can modulate DNA methylation and thereby contribute to aging and tumorigenesis. ...
Recent studies have also shown that dietary factors can modulate DNA methylation and thereby contribute to aging and tumorigenesis. . …
EGCG down-regulates telomerase in human breast carcinoma MCF-7 cells, leading to suppression of cell viability and induction of apoptosis.
Mittal A, Pate MS, Wylie RC, Tollefsbol TO, Katiyar SK. Mittal A, et al. Among authors: tollefsbol to. Int J Oncol. 2004 Mar;24(3):703-10. Int J Oncol. 2004. PMID: 14767556
Treatment of EGCG for 48 and 72 h markedly increased the percentage of apoptotic cells (32-51%) in MCF-7 cells compared to that of non-EGCG treated cells (8-14%). ...Together, our results indicate that EGCG down-regulates telomerase in human breast carcinoma MCF-7 cells, l …
Treatment of EGCG for 48 and 72 h markedly increased the percentage of apoptotic cells (32-51%) in MCF-7 cells compared to that of no …
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