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The antiviral activity of Toll-like receptor 7 and 7/8 agonists.
Miller RL, Meng TC, Tomai MA. Miller RL, et al. Among authors: tomai ma. Drug News Perspect. 2008 Mar;21(2):69-87. doi: 10.1358/dnp.2008.21.2.1188193. Drug News Perspect. 2008. PMID: 18389099 Review.
The use of Toll-like receptor 7/8 agonists as vaccine adjuvants.
Vasilakos JP, Tomai MA. Vasilakos JP, et al. Among authors: tomai ma. Expert Rev Vaccines. 2013 Jul;12(7):809-19. doi: 10.1586/14760584.2013.811208. Expert Rev Vaccines. 2013. PMID: 23885825 Review.
NK1.1+ cells mediate the antitumor effects of a dual Toll-like receptor 7/8 agonist in the disseminated B16-F10 melanoma model.
Dumitru CD, Antonysamy MA, Gorski KS, Johnson DD, Reddy LG, Lutterman JL, Piri MM, Proksch J, McGurran SM, Egging EA, Cochran FR, Lipson KE, Tomai MA, Gullikson GW. Dumitru CD, et al. Among authors: tomai ma. Cancer Immunol Immunother. 2009 Apr;58(4):575-87. doi: 10.1007/s00262-008-0581-7. Epub 2008 Sep 13. Cancer Immunol Immunother. 2009. PMID: 18791716
Plasmacytoid dendritic cells produce cytokines and mature in response to the TLR7 agonists, imiquimod and resiquimod.
Gibson SJ, Lindh JM, Riter TR, Gleason RM, Rogers LM, Fuller AE, Oesterich JL, Gorden KB, Qiu X, McKane SW, Noelle RJ, Miller RL, Kedl RM, Fitzgerald-Bocarsly P, Tomai MA, Vasilakos JP. Gibson SJ, et al. Among authors: tomai ma. Cell Immunol. 2002 Jul-Aug;218(1-2):74-86. doi: 10.1016/s0008-8749(02)00517-8. Cell Immunol. 2002. PMID: 12470615
Synthetic TLR agonists reveal functional differences between human TLR7 and TLR8.
Gorden KB, Gorski KS, Gibson SJ, Kedl RM, Kieper WC, Qiu X, Tomai MA, Alkan SS, Vasilakos JP. Gorden KB, et al. Among authors: tomai ma. J Immunol. 2005 Feb 1;174(3):1259-68. doi: 10.4049/jimmunol.174.3.1259. J Immunol. 2005. PMID: 15661881
Imidazoquinoline Toll-like receptor 8 agonists activate human newborn monocytes and dendritic cells through adenosine-refractory and caspase-1-dependent pathways.
Philbin VJ, Dowling DJ, Gallington LC, Cort├ęs G, Tan Z, Suter EE, Chi KW, Shuckett A, Stoler-Barak L, Tomai M, Miller RL, Mansfield K, Levy O. Philbin VJ, et al. Among authors: tomai m. J Allergy Clin Immunol. 2012 Jul;130(1):195-204.e9. doi: 10.1016/j.jaci.2012.02.042. Epub 2012 Apr 21. J Allergy Clin Immunol. 2012. PMID: 22521247 Free PMC article.
Administration of a dual toll-like receptor 7 and toll-like receptor 8 agonist protects against influenza in rats.
Hammerbeck DM, Burleson GR, Schuller CJ, Vasilakos JP, Tomai M, Egging E, Cochran FR, Woulfe S, Miller RL. Hammerbeck DM, et al. Among authors: tomai m. Antiviral Res. 2007 Jan;73(1):1-11. doi: 10.1016/j.antiviral.2006.07.011. Epub 2006 Aug 18. Antiviral Res. 2007. PMID: 16959331
Dendritic cells from HIV-1 infected individuals are less responsive to toll-like receptor (TLR) ligands.
Martinson JA, Roman-Gonzalez A, Tenorio AR, Montoya CJ, Gichinga CN, Rugeles MT, Tomai M, Krieg AM, Ghanekar S, Baum LL, Landay AL. Martinson JA, et al. Among authors: tomai m. Cell Immunol. 2007 Nov-Dec;250(1-2):75-84. doi: 10.1016/j.cellimm.2008.01.007. Epub 2008 Mar 10. Cell Immunol. 2007. PMID: 18334250 Free PMC article.
A randomized, controlled, molecular study of condylomata acuminata clearance during treatment with imiquimod.
Tyring SK, Arany I, Stanley MA, Tomai MA, Miller RL, Smith MH, McDermott DJ, Slade HB. Tyring SK, et al. Among authors: tomai ma. J Infect Dis. 1998 Aug;178(2):551-5. doi: 10.1086/517472. J Infect Dis. 1998. PMID: 9697742 Clinical Trial.
Synthesis and structure-activity-relationships of 1H-imidazo[4,5-c]quinolines that induce interferon production.
Gerster JF, Lindstrom KJ, Miller RL, Tomai MA, Birmachu W, Bomersine SN, Gibson SJ, Imbertson LM, Jacobson JR, Knafla RT, Maye PV, Nikolaides N, Oneyemi FY, Parkhurst GJ, Pecore SE, Reiter MJ, Scribner LS, Testerman TL, Thompson NJ, Wagner TL, Weeks CE, Andre JD, Lagain D, Bastard Y, Lupu M. Gerster JF, et al. Among authors: tomai ma. J Med Chem. 2005 May 19;48(10):3481-91. doi: 10.1021/jm049211v. J Med Chem. 2005. PMID: 15887957
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