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Drug discovery opportunities from apoptosis research.
Reed JC, Tomaselli KJ. Reed JC, et al. Curr Opin Biotechnol. 2000 Dec;11(6):586-92. doi: 10.1016/s0958-1669(00)00148-8. Curr Opin Biotechnol. 2000. PMID: 11102794 Review.
Bcl-xL functions downstream of caspase-8 to inhibit Fas- and tumor necrosis factor receptor 1-induced apoptosis of MCF7 breast carcinoma cells.
Srinivasan A, Li F, Wong A, Kodandapani L, Smidt R Jr, Krebs JF, Fritz LC, Wu JC, Tomaselli KJ. Srinivasan A, et al. J Biol Chem. 1998 Feb 20;273(8):4523-9. doi: 10.1074/jbc.273.8.4523. J Biol Chem. 1998. PMID: 9468507
Activation of the CED3/ICE-related protease CPP32 in cerebellar granule neurons undergoing apoptosis but not necrosis.
Armstrong RC, Aja TJ, Hoang KD, Gaur S, Bai X, Alnemri ES, Litwack G, Karanewsky DS, Fritz LC, Tomaselli KJ. Armstrong RC, et al. J Neurosci. 1997 Jan 15;17(2):553-62. doi: 10.1523/JNEUROSCI.17-02-00553.1997. J Neurosci. 1997. PMID: 8987778 Free PMC article.
Fas-induced activation of the cell death-related protease CPP32 Is inhibited by Bcl-2 and by ICE family protease inhibitors.
Armstrong RC, Aja T, Xiang J, Gaur S, Krebs JF, Hoang K, Bai X, Korsmeyer SJ, Karanewsky DS, Fritz LC, Tomaselli KJ. Armstrong RC, et al. J Biol Chem. 1996 Jul 12;271(28):16850-5. doi: 10.1074/jbc.271.28.16850. J Biol Chem. 1996. PMID: 8663439
Characterization of the caspase inhibitor IDN-1965 in a model of apoptosis-associated liver injury.
Hoglen NC, Hirakawa BP, Fisher CD, Weeks S, Srinivasan A, Wong AM, Valentino KL, Tomaselli KJ, Bai X, Karanewsky DS, Contreras PC. Hoglen NC, et al. J Pharmacol Exp Ther. 2001 May;297(2):811-8. J Pharmacol Exp Ther. 2001. PMID: 11303074
Heavy membrane-associated caspase 3: identification, isolation, and characterization.
Krebs JF, Srinivasan A, Wong AM, Tomaselli KJ, Fritz LC, Wu JC. Krebs JF, et al. Biochemistry. 2000 Dec 26;39(51):16056-63. doi: 10.1021/bi001007w. Biochemistry. 2000. PMID: 11123933
Activation of membrane-associated procaspase-3 is regulated by Bcl-2.
Krebs JF, Armstrong RC, Srinivasan A, Aja T, Wong AM, Aboy A, Sayers R, Pham B, Vu T, Hoang K, Karanewsky DS, Leist C, Schmitz A, Wu JC, Tomaselli KJ, Fritz LC. Krebs JF, et al. J Cell Biol. 1999 Mar 8;144(5):915-26. doi: 10.1083/jcb.144.5.915. J Cell Biol. 1999. PMID: 10085291 Free PMC article.
Interaction of the baculovirus anti-apoptotic protein p35 with caspases. Specificity, kinetics, and characterization of the caspase/p35 complex.
Zhou Q, Krebs JF, Snipas SJ, Price A, Alnemri ES, Tomaselli KJ, Salvesen GS. Zhou Q, et al. Biochemistry. 1998 Jul 28;37(30):10757-65. doi: 10.1021/bi980893w. Biochemistry. 1998. PMID: 9692966
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