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The 3,7-diazabicyclo[3.3.1]nonane scaffold for subtype selective nicotinic acetylcholine receptor (nAChR) ligands. Part 1: the influence of different hydrogen bond acceptor systems on alkyl and (hetero)aryl substituents.
Eibl C, Tomassoli I, Munoz L, Stokes C, Papke RL, Gündisch D. Eibl C, et al. Among authors: tomassoli i. Bioorg Med Chem. 2013 Dec 1;21(23):7283-308. doi: 10.1016/j.bmc.2013.09.059. Epub 2013 Oct 5. Bioorg Med Chem. 2013. PMID: 24156938 Free PMC article.
Bispidine as a Privileged Scaffold.
Tomassoli I, Gündisch D. Tomassoli I, et al. Curr Top Med Chem. 2016;16(11):1314-42. doi: 10.2174/1568026615666150915111434. Curr Top Med Chem. 2016. PMID: 26369817 Review.
Differential modulation of brain nicotinic acetylcholine receptor function by cytisine, varenicline, and two novel bispidine compounds: emergent properties of a hybrid molecule.
Peng C, Stokes C, Mineur YS, Picciotto MR, Tian C, Eibl C, Tomassoli I, Guendisch D, Papke RL. Peng C, et al. Among authors: tomassoli i. J Pharmacol Exp Ther. 2013 Nov;347(2):424-37. doi: 10.1124/jpet.113.206904. Epub 2013 Aug 19. J Pharmacol Exp Ther. 2013. PMID: 23959137 Free PMC article.
Synthesis, biological assessment and molecular modeling of new dihydroquinoline-3-carboxamides and dihydroquinoline-3-carbohydrazide derivatives as cholinesterase inhibitors, and Ca channel antagonists.
Tomassoli I, Ismaili L, Pudlo M, de Los Ríos C, Soriano E, Colmena I, Gandía L, Rivas L, Samadi A, Marco-Contelles J, Refouvelet B. Tomassoli I, et al. Eur J Med Chem. 2011 Jan;46(1):1-10. doi: 10.1016/j.ejmech.2010.08.054. Epub 2010 Dec 15. Eur J Med Chem. 2011. PMID: 21111515