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Increased amounts of a novel penicillin-binding protein in a strain of methicillin-resistant Staphylococcus aureus exposed to nafcillin.
Chambers HF, Hartman BJ, Tomasz A. Chambers HF, et al. Among authors: tomasz a. J Clin Invest. 1985 Jul;76(1):325-31. doi: 10.1172/JCI111965. J Clin Invest. 1985. PMID: 4019783 Free PMC article.
In addition to the four typical penicillin-binding proteins (PBPs), a strain of heterogeneously methicillin-resistant Staphylococcus aureus produced an extra 78-kD PBP (PBP 2a) that had a low affinity for nafcillin and penicillin. Addition of nafcillin to cultures o …
In addition to the four typical penicillin-binding proteins (PBPs), a strain of heterogeneously methicillin-resistant Staphylococcus …
Studies on the mechanism of intrinsic resistance to beta-lactam antibiotics in group D streptococci.
Williamson R, Calderwood SB, Moellering RC Jr, Tomasz A. Williamson R, et al. Among authors: tomasz a. J Gen Microbiol. 1983 Mar;129(3):813-22. doi: 10.1099/00221287-129-3-813. J Gen Microbiol. 1983. PMID: 6409985
Beta-lactam-specific resistant mutants of Staphylococcus aureus.
Tonin E, Tomasz A. Tonin E, et al. Among authors: tomasz a. Antimicrob Agents Chemother. 1986 Oct;30(4):577-83. doi: 10.1128/aac.30.4.577. Antimicrob Agents Chemother. 1986. PMID: 3539012 Free PMC article.
In a highly methicillin-resistant mutant (MIC, 150 micrograms/ml), PBPs 2 and 3 were no longer detectable by the penicillin binding assay. Instead, a new PBP of poor binding capacity and anomalous molecular size (about 78 kilodaltons [kDa]) appeared in these cells. …
In a highly methicillin-resistant mutant (MIC, 150 micrograms/ml), PBPs 2 and 3 were no longer detectable by the penicillin binding a …
Altered penicillin-binding proteins in methicillin-resistant strains of Staphylococcus aureus.
Hartman B, Tomasz A. Hartman B, et al. Among authors: tomasz a. Antimicrob Agents Chemother. 1981 May;19(5):726-35. doi: 10.1128/aac.19.5.726. Antimicrob Agents Chemother. 1981. PMID: 7294764 Free PMC article.
The penicillin-binding proteins (PBPs) of a methicillin-resistant (MR) and a methicillin-susceptible (MS) Staphylococcus aureus were compared by various approaches involving the use of high-specific-activity [3H]penicillin as a reagent. ...Thus, the pH-depend …
The penicillin-binding proteins (PBPs) of a methicillin-resistant (MR) and a methicillin-susceptible (MS) Staphylococcus aureu …
Penicillin-binding proteins in bacteria.
Tomasz A. Tomasz A. Ann Intern Med. 1982 Apr;96(4):502-4. doi: 10.7326/0003-4819-96-4-502. Ann Intern Med. 1982. PMID: 7039448 Review.
Application of this technique has led to a remarkable number of novel observations that have substantially modified our view of the mode of action of beta-lactam antibiotics....
Application of this technique has led to a remarkable number of novel observations that have substantially modified our view of the m …
Low-affinity penicillin-binding protein associated with beta-lactam resistance in Staphylococcus aureus.
Hartman BJ, Tomasz A. Hartman BJ, et al. Among authors: tomasz a. J Bacteriol. 1984 May;158(2):513-6. doi: 10.1128/JB.158.2.513-516.1984. J Bacteriol. 1984. PMID: 6563036 Free PMC article.
We detected a high-molecular-weight PBP (PBP-2a; approximate size, 78,000 daltons) that was only present in the resistant bacteria but not in the isogenic sensitive strain. ...
We detected a high-molecular-weight PBP (PBP-2a; approximate size, 78,000 daltons) that was only present in the resistant bacteria bu …
Inhibition of cell wall synthesis and acylation of the penicillin binding proteins during prolonged exposure of growing Streptococcus pneumoniae to benzylpenicillin.
Williamson R, Tomasz A. Williamson R, et al. Among authors: tomasz a. Eur J Biochem. 1985 Sep 16;151(3):475-83. doi: 10.1111/j.1432-1033.1985.tb09126.x. Eur J Biochem. 1985. PMID: 4029142
We conclude that inhibition of bacterial growth does not require a complete inhibition or even a major decline in the rate of peptidoglycan incorporation. Rather, inhibition of growth must be caused by an as yet undefined process that stops cell division when the ra …
We conclude that inhibition of bacterial growth does not require a complete inhibition or even a major decline in the rate of …
Alterations in penicillin-binding proteins of clinical and laboratory isolates of pathogenic Streptococcus pneumoniae with low levels of penicillin resistance.
Handwerger S, Tomasz A. Handwerger S, et al. Among authors: tomasz a. J Infect Dis. 1986 Jan;153(1):83-9. doi: 10.1093/infdis/153.1.83. J Infect Dis. 1986. PMID: 3941290
Several recent surveys of clinical isolates have indicated that substantial fractions of naturally occurring populations of Streptococcus pneumoniae have undergone a distinct upward move in the required minimal inhibitory concentration (MIC) of benzylpenicillin (from a
Several recent surveys of clinical isolates have indicated that substantial fractions of naturally occurring populations of Streptococcus pn …
Penicillin-binding proteins and the antibacterial effectiveness of beta-lactam antibiotics.
Tomasz A. Tomasz A. Rev Infect Dis. 1986 Jul-Aug;8 Suppl 3:S260-78. doi: 10.1093/clinids/8.supplement_3.s260. Rev Infect Dis. 1986. PMID: 3092301 Review.
The quantitative relationship between the minimal inhibitory concentration of a beta-lactam antibiotic and its reactivity with certain PBPs is not well understood. ...A new form of antibiotic resistance involving mutational alteration of PBPs (in the direction of lo …
The quantitative relationship between the minimal inhibitory concentration of a beta-lactam antibiotic and its reactivity with certai …
Horizontal transfer of penicillin-binding protein genes in penicillin-resistant clinical isolates of Streptococcus pneumoniae.
Dowson CG, Hutchison A, Brannigan JA, George RC, Hansman D, Liñares J, Tomasz A, Smith JM, Spratt BG. Dowson CG, et al. Among authors: tomasz a. Proc Natl Acad Sci U S A. 1989 Nov;86(22):8842-6. doi: 10.1073/pnas.86.22.8842. Proc Natl Acad Sci U S A. 1989. PMID: 2813426 Free PMC article.
In contrast the PBP2B genes of the penicillin-resistant strains show approximately equal to 14% sequence divergence from those of the penicillin-sensitive strains and the development of penicillin resistance has involved the replacement, presumably by transformation, of the origi …
In contrast the PBP2B genes of the penicillin-resistant strains show approximately equal to 14% sequence divergence from those of the penici …
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