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Suppression of beta-lactam antibiotic resistance in a methicillin-resistant Staphylococcus aureus through synergic action of early cell wall inhibitors and some other antibiotics.
Sieradzki K, Tomasz A. Sieradzki K, et al. J Antimicrob Chemother. 1997 May;39 Suppl A:47-51. doi: 10.1093/jac/39.suppl_1.47. J Antimicrob Chemother. 1997. PMID: 9511062
We tested the effect of a number of mechanistically distinct antibacterial agents on the expression of methicillin resistance in a highly and homogeneously resistant strain of methicillin-resistant Staphylococcus aureus. ...
We tested the effect of a number of mechanistically distinct antibacterial agents on the expression of methicillin resistance in a
Beta-lactam-specific resistant mutants of Staphylococcus aureus.
Tonin E, Tomasz A. Tonin E, et al. Antimicrob Agents Chemother. 1986 Oct;30(4):577-83. doi: 10.1128/aac.30.4.577. Antimicrob Agents Chemother. 1986. PMID: 3539012 Free PMC article.
In a highly methicillin-resistant mutant (MIC, 150 micrograms/ml), PBPs 2 and 3 were no longer detectable by the penicillin binding assay. Instead, a new PBP of poor binding capacity and anomalous molecular size (about 78 kilodaltons [kDa]) appeared in these cells. …
In a highly methicillin-resistant mutant (MIC, 150 micrograms/ml), PBPs 2 and 3 were no longer detectable by the penicillin binding a …
Altered penicillin-binding proteins in methicillin-resistant strains of Staphylococcus aureus.
Hartman B, Tomasz A. Hartman B, et al. Antimicrob Agents Chemother. 1981 May;19(5):726-35. doi: 10.1128/aac.19.5.726. Antimicrob Agents Chemother. 1981. PMID: 7294764 Free PMC article.
The penicillin-binding proteins (PBPs) of a methicillin-resistant (MR) and a methicillin-susceptible (MS) Staphylococcus aureus were compared by various approaches involving the use of high-specific-activity [3H]penicillin as a reagent. ...Thus, the pH-depend …
The penicillin-binding proteins (PBPs) of a methicillin-resistant (MR) and a methicillin-susceptible (MS) Staphylococcus aureu …
Low-affinity penicillin-binding protein associated with beta-lactam resistance in Staphylococcus aureus.
Hartman BJ, Tomasz A. Hartman BJ, et al. J Bacteriol. 1984 May;158(2):513-6. doi: 10.1128/JB.158.2.513-516.1984. J Bacteriol. 1984. PMID: 6563036 Free PMC article.
We detected a high-molecular-weight PBP (PBP-2a; approximate size, 78,000 daltons) that was only present in the resistant bacteria but not in the isogenic sensitive strain. ...
We detected a high-molecular-weight PBP (PBP-2a; approximate size, 78,000 daltons) that was only present in the resistant bacteria bu …
Increased amounts of a novel penicillin-binding protein in a strain of methicillin-resistant Staphylococcus aureus exposed to nafcillin.
Chambers HF, Hartman BJ, Tomasz A. Chambers HF, et al. J Clin Invest. 1985 Jul;76(1):325-31. doi: 10.1172/JCI111965. J Clin Invest. 1985. PMID: 4019783 Free PMC article.
In addition to the four typical penicillin-binding proteins (PBPs), a strain of heterogeneously methicillin-resistant Staphylococcus aureus produced an extra 78-kD PBP (PBP 2a) that had a low affinity for nafcillin and penicillin. Addition of nafcillin to cultures o …
In addition to the four typical penicillin-binding proteins (PBPs), a strain of heterogeneously methicillin-resistant Staphylococcus …
Penicillin-binding proteins and the antibacterial effectiveness of beta-lactam antibiotics.
Tomasz A. Tomasz A. Rev Infect Dis. 1986 Jul-Aug;8 Suppl 3:S260-78. doi: 10.1093/clinids/8.supplement_3.s260. Rev Infect Dis. 1986. PMID: 3092301 Review.
The quantitative relationship between the minimal inhibitory concentration of a beta-lactam antibiotic and its reactivity with certain PBPs is not well understood. ...A new form of antibiotic resistance involving mutational alteration of PBPs (in the direction of lo …
The quantitative relationship between the minimal inhibitory concentration of a beta-lactam antibiotic and its reactivity with certai …
Peptidoglycan composition of a highly methicillin-resistant Staphylococcus aureus strain. The role of penicillin binding protein 2A.
de Jonge BL, Chang YS, Gage D, Tomasz A. de Jonge BL, et al. J Biol Chem. 1992 Jun 5;267(16):11248-54. J Biol Chem. 1992. PMID: 1597460
This extra PBP is thought to be a transpeptidase essential for the continued cell wall synthesis and growth in the presence of beta-lactam antibiotics. ...Our experiments provided no experimental data for a unique transpeptidase activity associated with PBP2A....
This extra PBP is thought to be a transpeptidase essential for the continued cell wall synthesis and growth in the presence of beta-l …
Characterization of cell wall polymers secreted into the growth medium of lysis-defective pneumococci during treatment with penicillin and other inhibitors of cell wall synthesis.
Hakenbeck R, Waks S, Tomasz A. Hakenbeck R, et al. Antimicrob Agents Chemother. 1978 Feb;13(2):302-11. doi: 10.1128/aac.13.2.302. Antimicrob Agents Chemother. 1978. PMID: 25618 Free PMC article.
The secreted polymers were separated into three fractions by a combination of gel filtration on agarose and sodium dodecyl sulfate-gel electrophoresis. Fraction I had a high apparent molecular size and contained the Forssman antigen in complex with material exhibiti …
The secreted polymers were separated into three fractions by a combination of gel filtration on agarose and sodium dodecyl sulfate-ge …
Secretion of cell wall polymers into the growth medium of lysis-defective pneumococci during treatment with penicillin and other inhibitors of cell wall synthesis.
Waks S, Tomasz A. Waks S, et al. Antimicrob Agents Chemother. 1978 Feb;13(2):293-301. doi: 10.1128/aac.13.2.293. Antimicrob Agents Chemother. 1978. PMID: 25617 Free PMC article.
Autolysin-defective pneumococci secrete into the growth medium choline-containing macromolecules during treatment with any one of a large number of inhibitors of cell wall biosynthesis, including beta-lactams, beta-halogeno-d-alanines, cephalosporins, and d-cycloserine. .. …
Autolysin-defective pneumococci secrete into the growth medium choline-containing macromolecules during treatment with any one of a l …
Suppression of the lytic and bactericidal effects of cell wallinhibitory antibiotics.
Lopez R, Ronda-Lain C, Tapia A, Waks SB, Tomasz A. Lopez R, et al. Antimicrob Agents Chemother. 1976 Oct;10(4):697-706. doi: 10.1128/aac.10.4.697. Antimicrob Agents Chemother. 1976. PMID: 10831 Free PMC article.
The pH-dependent protection phenomenon resembled in several respects the antibiotic "tolerance" of pneumococci with a defective autolytic system. ...(iii) The protection effect was reversible; lysis and loss of viability could be triggered by a postincubation of the …
The pH-dependent protection phenomenon resembled in several respects the antibiotic "tolerance" of pneumococci with a defective autol …
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