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Presenilin-dependent intramembrane cleavage of ephrin-B1.
Tomita T, Tanaka S, Morohashi Y, Iwatsubo T. Tomita T, et al. Mol Neurodegener. 2006 Jun 12;1:2. doi: 10.1186/1750-1326-1-2. Mol Neurodegener. 2006. PMID: 16930449 Free PMC article.
Molecular dissection of domains in mutant presenilin 2 that mediate overproduction of amyloidogenic forms of amyloid beta peptides. Inability of truncated forms of PS2 with familial Alzheimer's disease mutation to increase secretion of Abeta42.
Tomita T, Tokuhiro S, Hashimoto T, Aiba K, Saido TC, Maruyama K, Iwatsubo T. Tomita T, et al. J Biol Chem. 1998 Aug 14;273(33):21153-60. doi: 10.1074/jbc.273.33.21153. J Biol Chem. 1998. PMID: 9694871
The presenilin 2 loop domain interacts with the mu-calpain C-terminal region.
Shinozaki K, Maruyama K, Kume H, Tomita T, Saido TC, Iwatsubo T, Obata K. Shinozaki K, et al. Int J Mol Med. 1998 May;1(5):797-9. doi: 10.3892/ijmm.1.5.797. Int J Mol Med. 1998. PMID: 9852298
C terminus of presenilin is required for overproduction of amyloidogenic Abeta42 through stabilization and endoproteolysis of presenilin.
Tomita T, Takikawa R, Koyama A, Morohashi Y, Takasugi N, Saido TC, Maruyama K, Iwatsubo T. Tomita T, et al. J Neurosci. 1999 Dec 15;19(24):10627-34. doi: 10.1523/JNEUROSCI.19-24-10627.1999. J Neurosci. 1999. PMID: 10594046 Free PMC article.
[Molecular cell biology of presenilins].
Tomita T, Iwatsubo T. Tomita T, et al. Nihon Yakurigaku Zasshi. 1999 Dec;114(6):337-46. doi: 10.1254/fpj.114.337. Nihon Yakurigaku Zasshi. 1999. PMID: 10672594 Review. Japanese.
Molecular interactions between presenilin and calpain: inhibition of m-calpain protease activity by presenilin-1, 2 and cleavage of presenilin-1 by m-, mu-calpain.
Maruyama K, Usami M, Kametani F, Tomita T, Iwatsubo T, Saido TC, Mori H, Ishiura S. Maruyama K, et al. Int J Mol Med. 2000 Mar;5(3):269-73. doi: 10.3892/ijmm.5.3.269. Int J Mol Med. 2000. PMID: 10677567
Subcellular compartment and molecular subdomain of beta-amyloid precursor protein relevant to the Abeta 42-promoting effects of Alzheimer mutant presenilin 2.
Iwata H, Tomita T, Maruyama K, Iwatsubo T. Iwata H, et al. J Biol Chem. 2001 Jun 15;276(24):21678-85. doi: 10.1074/jbc.M007989200. Epub 2001 Mar 30. J Biol Chem. 2001. PMID: 11283011
Molecular cloning and characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4.
Morohashi Y, Hatano N, Ohya S, Takikawa R, Watabiki T, Takasugi N, Imaizumi Y, Tomita T, Iwatsubo T. Morohashi Y, et al. J Biol Chem. 2002 Apr 26;277(17):14965-75. doi: 10.1074/jbc.M200897200. Epub 2002 Feb 14. J Biol Chem. 2002. PMID: 11847232
The mechanism of gamma-secretase activities through high molecular weight complex formation of presenilins is conserved in Drosophila melanogaster and mammals.
Takasugi N, Takahashi Y, Morohashi Y, Tomita T, Iwatsubo T. Takasugi N, et al. J Biol Chem. 2002 Dec 20;277(51):50198-205. doi: 10.1074/jbc.M205352200. Epub 2002 Oct 17. J Biol Chem. 2002. PMID: 12388554
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