Tomita T - Search Results

1

Secretase inhibitors and modulators for Alzheimer's disease treatment.

Tomita T. Tomita T. Expert Rev Neurother. 2009 May;9(5):661-79. doi: 10.1586/ern.09.24. Expert Rev Neurother. 2009. PMID: 19402777 Review.

2

Familial Alzheimer's disease-linked mutations at Val717 of amyloid precursor protein are specific for the increased secretion of A beta 42(43).

Maruyama K, Tomita T, Shinozaki K, Kume H, Asada H, Saido TC, Ishiura S, Iwatsubo T, Obata K. Maruyama K, et al. Among authors: tomita t. Biochem Biophys Res Commun. 1996 Oct 23;227(3):730-5. doi: 10.1006/bbrc.1996.1577. Biochem Biophys Res Commun. 1996. PMID: 8886002

3

The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue.

Tomita T, Maruyama K, Saido TC, Kume H, Shinozaki K, Tokuhiro S, Capell A, Walter J, Grünberg J, Haass C, Iwatsubo T, Obata K. Tomita T, et al. Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):2025-30. doi: 10.1073/pnas.94.5.2025. Proc Natl Acad Sci U S A. 1997. PMID: 9050898 Free PMC article.

4

Molecular dissection of domains in mutant presenilin 2 that mediate overproduction of amyloidogenic forms of amyloid beta peptides. Inability of truncated forms of PS2 with familial Alzheimer's disease mutation to increase secretion of Abeta42.

Tomita T, Tokuhiro S, Hashimoto T, Aiba K, Saido TC, Maruyama K, Iwatsubo T. Tomita T, et al. J Biol Chem. 1998 Aug 14;273(33):21153-60. doi: 10.1074/jbc.273.33.21153. J Biol Chem. 1998. PMID: 9694871

5

[Genetic factors in the pathogenesis of Alzheimer's disease: roles of beta-amyloid and presenilins].

Iwatsubo T, Tomita T. Iwatsubo T, et al. Among authors: tomita t. Tanpakushitsu Kakusan Koso. 1998 Oct;43(13):1963-72. Tanpakushitsu Kakusan Koso. 1998. PMID: 9789459 Review. Japanese. No abstract available.

6

Enhancement of amyloid beta 42 secretion by 28 different presenilin 1 mutations of familial Alzheimer's disease.

Murayama O, Tomita T, Nihonmatsu N, Murayama M, Sun X, Honda T, Iwatsubo T, Takashima A. Murayama O, et al. Among authors: tomita t. Neurosci Lett. 1999 Apr 9;265(1):61-3. doi: 10.1016/s0304-3940(99)00187-1. Neurosci Lett. 1999. PMID: 10327206

7

Caveolin-3 upregulation activates beta-secretase-mediated cleavage of the amyloid precursor protein in Alzheimer's disease.

Nishiyama K, Trapp BD, Ikezu T, Ransohoff RM, Tomita T, Iwatsubo T, Kanazawa I, Hsiao KK, Lisanti MP, Okamoto T. Nishiyama K, et al. Among authors: tomita t. J Neurosci. 1999 Aug 1;19(15):6538-48. doi: 10.1523/JNEUROSCI.19-15-06538.1999. J Neurosci. 1999. PMID: 10414982 Free PMC article.

8

C terminus of presenilin is required for overproduction of amyloidogenic Abeta42 through stabilization and endoproteolysis of presenilin.

Tomita T, Takikawa R, Koyama A, Morohashi Y, Takasugi N, Saido TC, Maruyama K, Iwatsubo T. Tomita T, et al. J Neurosci. 1999 Dec 15;19(24):10627-34. doi: 10.1523/JNEUROSCI.19-24-10627.1999. J Neurosci. 1999. PMID: 10594046 Free PMC article.

9

[Molecular cell biology of presenilins].

Tomita T, Iwatsubo T. Tomita T, et al. Nihon Yakurigaku Zasshi. 1999 Dec;114(6):337-46. doi: 10.1254/fpj.114.337. Nihon Yakurigaku Zasshi. 1999. PMID: 10672594 Review. Japanese.

10

Variant Alzheimer's disease with spastic paraparesis and cotton wool plaques is caused by PS-1 mutations that lead to exceptionally high amyloid-beta concentrations.

Houlden H, Baker M, McGowan E, Lewis P, Hutton M, Crook R, Wood NW, Kumar-Singh S, Geddes J, Swash M, Scaravilli F, Holton JL, Lashley T, Tomita T, Hashimoto T, Verkkoniemi A, Kalimo H, Somer M, Paetau A, Martin JJ, Van Broeckhoven C, Golde T, Hardy J, Haltia M, Revesz T. Houlden H, et al. Among authors: tomita t. Ann Neurol. 2000 Nov;48(5):806-8. Ann Neurol. 2000. PMID: 11079548

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