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An intestinal epithelial defect conferring ER stress results in inflammation involving both innate and adaptive immunity.
Eri RD, Adams RJ, Tran TV, Tong H, Das I, Roche DK, Oancea I, Png CW, Jeffery PL, Radford-Smith GL, Cook MC, Florin TH, McGuckin MA. Eri RD, et al. Among authors: Tong H. Mucosal Immunol. 2011 May;4(3):354-64. doi: 10.1038/mi.2010.74. Epub 2010 Nov 24. Mucosal Immunol. 2011. PMID: 21107311 Free PMC article.
Winnie also displayed a significant increase in mRNA expression of the mucosal T(H)17 signature genes Il17a, IL17f, Tgfb, and Ccr6, particularly in the distal colon. Winnie mesenteric lymph node leukocytes secreted multiple T(H)1, T(H)2, and T(H)17 cytokines on activation, with a large increase in interleukin-17A (IL-17A) progressively with age. ...
Winnie also displayed a significant increase in mRNA expression of the mucosal T(H)17 signature genes Il17a, IL17f, Tgfb, and Ccr6, p …
Molecular trafficking mechanisms of multipotent mesenchymal stem cells derived from human bone marrow and placenta.
Brooke G, Tong H, Levesque JP, Atkinson K. Brooke G, et al. Among authors: Tong H. Stem Cells Dev. 2008 Oct;17(5):929-40. doi: 10.1089/scd.2007.0156. Stem Cells Dev. 2008. PMID: 18564033
We compared potential trafficking mechanisms used by human (h) multipotent mesenchymal stem cells (MSC) derived from bone marrow (bm) or placenta (p). ...
We compared potential trafficking mechanisms used by human (h) multipotent mesenchymal stem cells (MSC) derived from bone marrow (bm) …
A phase I clinical trial of CD1c (BDCA-1)+ dendritic cells pulsed with HLA-A*0201 peptides for immunotherapy of metastatic hormone refractory prostate cancer.
Prue RL, Vari F, Radford KJ, Tong H, Hardy MY, D'Rozario R, Waterhouse NJ, Rossetti T, Coleman R, Tracey C, Goossen H, Gounder V, Crosbie G, Hancock S, Diaz-Guilas S, Mainwaring P, Swindle P, Hart DN. Prue RL, et al. Among authors: Tong H. J Immunother. 2015 Feb-Mar;38(2):71-6. doi: 10.1097/CJI.0000000000000063. J Immunother. 2015. PMID: 25658616 Clinical Trial.
The effect of interleukin-22 treatment on autoimmune diabetes in the NOD mouse.
Borg DJ, Wang R, Murray L, Tong H, Steptoe RJ, McGuckin MA, Hasnain SZ. Borg DJ, et al. Among authors: Tong H. Diabetologia. 2017 Nov;60(11):2256-2261. doi: 10.1007/s00125-017-4392-2. Epub 2017 Aug 4. Diabetologia. 2017. PMID: 28779211 Free PMC article.
Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress.
Hasnain SZ, Borg DJ, Harcourt BE, Tong H, Sheng YH, Ng CP, Das I, Wang R, Chen AC, Loudovaris T, Kay TW, Thomas HE, Whitehead JP, Forbes JM, Prins JB, McGuckin MA. Hasnain SZ, et al. Among authors: Tong H. Nat Med. 2014 Dec;20(12):1417-26. doi: 10.1038/nm.3705. Epub 2014 Nov 2. Nat Med. 2014. PMID: 25362253
High Fat Diets Induce Colonic Epithelial Cell Stress and Inflammation that is Reversed by IL-22.
Gulhane M, Murray L, Lourie R, Tong H, Sheng YH, Wang R, Kang A, Schreiber V, Wong KY, Magor G, Denman S, Begun J, Florin TH, Perkins A, Cuív PÓ, McGuckin MA, Hasnain SZ. Gulhane M, et al. Among authors: Tong H. Sci Rep. 2016 Jun 28;6:28990. doi: 10.1038/srep28990. Sci Rep. 2016. PMID: 27350069 Free PMC article.
MUC13 protects colorectal cancer cells from death by activating the NF-κB pathway and is a potential therapeutic target.
Sheng YH, He Y, Hasnain SZ, Wang R, Tong H, Clarke DT, Lourie R, Oancea I, Wong KY, Lumley JW, Florin TH, Sutton P, Hooper JD, McMillan NA, McGuckin MA. Sheng YH, et al. Among authors: Tong H. Oncogene. 2017 Feb 2;36(5):700-713. doi: 10.1038/onc.2016.241. Epub 2016 Jul 11. Oncogene. 2017. PMID: 27399336 Free PMC article.
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