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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 1
1961 1
1964 2
1969 1
1972 3
1973 1
1974 2
1975 7
1976 12
1977 5
1978 11
1979 5
1980 8
1981 3
1982 8
1983 7
1984 10
1985 12
1986 9
1987 12
1988 13
1989 16
1990 19
1991 17
1992 19
1993 16
1994 14
1995 18
1996 21
1997 26
1998 22
1999 26
2000 19
2001 21
2002 17
2003 27
2004 33
2005 30
2006 31
2007 34
2008 42
2009 34
2010 53
2011 55
2012 49
2013 45
2014 66
2015 75
2016 71
2017 79
2018 57
2019 82
2020 92
2021 107
2022 78
2023 73
2024 77
2025 37

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1,573 results

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Page 1
Microneedles for advanced ocular drug delivery.
Glover K, Mishra D, Gade S, Vora LK, Wu Y, Paredes AJ, Donnelly RF, Singh TRR. Glover K, et al. Adv Drug Deliv Rev. 2023 Oct;201:115082. doi: 10.1016/j.addr.2023.115082. Epub 2023 Sep 9. Adv Drug Deliv Rev. 2023. PMID: 37678648 Free article. Review.
Nonetheless, topical eye drops are associated with low bioavailability (<5%), and theintravitreal administration procedure is highly invasive, yielding poor patient acceptability. ...These platforms can enable localised drug delivery to the eye while enhan …
Nonetheless, topical eye drops are associated with low bioavailability (<5%), and theintravitreal administration procedure …
Effectiveness of topical insulin for the treatment of surface corneal pathologies.
Castro Mora MP, Palacio Varona J, Perez Riaño B, Laverde Cubides C, Rey-Rodriguez DV. Castro Mora MP, et al. Arch Soc Esp Oftalmol (Engl Ed). 2023 Apr;98(4):220-232. doi: 10.1016/j.oftale.2023.03.007. Epub 2023 Mar 5. Arch Soc Esp Oftalmol (Engl Ed). 2023. PMID: 36871851 Review.
The Purpose is to identify, through a systematic literature review, the current evidence regarding the effectiveness of topical insulin treatment in ocular surface pathologies. A literature search was implemented in Medline (Pubmed), Embase and Web Of Science medical index …
The Purpose is to identify, through a systematic literature review, the current evidence regarding the effectiveness of topical insul …
The role of topical insulin in ocular surface restoration: A review.
Krolo I, Behaegel J, Termote K, de Bruyn B, De Schepper M, Oellerich S, Ní Dhubhghaill S. Krolo I, et al. Surv Ophthalmol. 2024 Sep-Oct;69(5):805-817. doi: 10.1016/j.survophthal.2024.04.003. Epub 2024 Apr 10. Surv Ophthalmol. 2024. PMID: 38609022 Review.
Over the last decade, as more expensive therapeutics reach the market, topical insulin has returned to the forefront as an affordable option to improve corneal wound healing. There is still a paucity of data on the use and the efficacy of topical insulin, with no co …
Over the last decade, as more expensive therapeutics reach the market, topical insulin has returned to the forefront as an affordable …
Metals in cosmetics: implications for human health.
Borowska S, Brzóska MM. Borowska S, et al. J Appl Toxicol. 2015 Jun;35(6):551-72. doi: 10.1002/jat.3129. Epub 2015 Mar 23. J Appl Toxicol. 2015. PMID: 25809475 Review.
Cosmetics, preparations repeatedly applied directly to the human skin, mucous membranes, hair and nails, should be safe for health, however, recently there has been increasing concern about their safety. ...Metals occurring in cosmetics may undergo retention and act direct …
Cosmetics, preparations repeatedly applied directly to the human skin, mucous membranes, hair and nails, should be safe for health, h …
Ocular Pharmacology.
Novack GD, Robin AL. Novack GD, et al. J Clin Pharmacol. 2024 Sep;64(9):1068-1082. doi: 10.1002/jcph.2451. Epub 2024 May 6. J Clin Pharmacol. 2024. PMID: 38708561 Review.
Delivery routes include topical, intravitreal, and systemic. Patient dosing involves not only adherence issues common to all chronic diseases, but also performance requirements on eye drop instillation. Therapeutically, ocular diseases and their pharmacological trea …
Delivery routes include topical, intravitreal, and systemic. Patient dosing involves not only adherence issues common to all chronic …
Principles of pharmacology in the eye.
Awwad S, Mohamed Ahmed AHA, Sharma G, Heng JS, Khaw PT, Brocchini S, Lockwood A. Awwad S, et al. Br J Pharmacol. 2017 Dec;174(23):4205-4223. doi: 10.1111/bph.14024. Epub 2017 Oct 10. Br J Pharmacol. 2017. PMID: 28865239 Free PMC article. Review.
The eye is a highly specialized organ that is subject to a huge range of pathology. Both local and systemic disease may affect different anatomical regions of the eye. The least invasive routes for ocular drug administration are topical (e.g. eye drops …
The eye is a highly specialized organ that is subject to a huge range of pathology. Both local and systemic disease may affect differ …
Biodistribution of progesterone in the eye after topical ocular administration via drops or inserts.
Alambiaga-Caravaca AM, González Iglesias LG, Rodilla V, Kalia YN, López-Castellano A. Alambiaga-Caravaca AM, et al. Int J Pharm. 2023 Jan 5;630:122453. doi: 10.1016/j.ijpharm.2022.122453. Epub 2022 Nov 28. Int J Pharm. 2023. PMID: 36455753
Different formulations with PG in their composition (drops, a corneal/scleral-insert and scleral-inserts) were prepared and assayed. Using whole porcine eyes, the different formulations were topically administered to the ocular surface. Frozen eyes were dissected, t …
Different formulations with PG in their composition (drops, a corneal/scleral-insert and scleral-inserts) were prepared and assayed. …
Topical Insulin for Ocular Surface Disease.
Cid-Bertomeu P, Vilaltella M, Martínez M, Mir M, Huerva V. Cid-Bertomeu P, et al. J Ocul Pharmacol Ther. 2024 May;40(4):204-214. doi: 10.1089/jop.2024.0016. Epub 2024 Mar 22. J Ocul Pharmacol Ther. 2024. PMID: 38527183 Review.
Results: While off-label use of topical insulin has shown promising results in refractory corneal epithelial defects, its efficacy in dry eye disease is yet to be demonstrated. ...By highlighting indications, preparation methods, side effects, and efficacy ou …
Results: While off-label use of topical insulin has shown promising results in refractory corneal epithelial defects, its efficacy in …
Acanthamoeba keratitis.
Illingworth CD, Cook SD. Illingworth CD, et al. Surv Ophthalmol. 1998 May-Jun;42(6):493-508. doi: 10.1016/s0039-6257(98)00004-6. Surv Ophthalmol. 1998. PMID: 9635900 Review.
There is an increased risk when contact lens rinsing and soaking solutions are prepared with nonsterile water and salt tablets. The clinical picture is often characterized by severe pain with an early superficial keratitis that is often treated as herpes simplex infection. …
There is an increased risk when contact lens rinsing and soaking solutions are prepared with nonsterile water and salt tablets. The c …
Evaluation of topical hesperetin matrix film for back-of-the-eye delivery.
Adelli GR, Hingorani T, Punyamurthula N, Balguri SP, Majumdar S. Adelli GR, et al. Eur J Pharm Biopharm. 2015 May;92:74-82. doi: 10.1016/j.ejpb.2015.02.006. Epub 2015 Feb 26. Eur J Pharm Biopharm. 2015. PMID: 25728824 Free PMC article.
PURPOSE: The goal of the present study was to develop a poly (ethylene oxide) N10 (PEO N10) based melt-cast matrix system for efficient and prolonged delivery of hesperetin (HT), a promising bioflavonoid, to the posterior segment of the eye through the topical route …
PURPOSE: The goal of the present study was to develop a poly (ethylene oxide) N10 (PEO N10) based melt-cast matrix system for efficient and …
1,573 results