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A disorder-related variant (E420K) of a PP2A-regulatory subunit (PPP2R5D) causes constitutively active AKT-mTOR signaling and uncoordinated cell growth.
Papke CM, Smolen KA, Swingle MR, Cressey L, Heng RA, Toporsian M, Deng L, Hagen J, Shen Y, Chung WK, Kettenbach AN, Honkanen RE. Papke CM, et al. Among authors: toporsian m. J Biol Chem. 2021 Jan-Jun;296:100313. doi: 10.1016/j.jbc.2021.100313. Epub 2021 Jan 20. J Biol Chem. 2021. PMID: 33482199 Free PMC article.
Spontaneous adult-onset pulmonary arterial hypertension attributable to increased endothelial oxidative stress in a murine model of hereditary hemorrhagic telangiectasia.
Toporsian M, Jerkic M, Zhou YQ, Kabir MG, Yu LX, McIntyre BA, Davis A, Wang YJ, Stewart DJ, Belik J, Husain M, Henkelman M, Letarte M. Toporsian M, et al. Arterioscler Thromb Vasc Biol. 2010 Mar;30(3):509-17. doi: 10.1161/ATVBAHA.109.200121. Epub 2009 Dec 30. Arterioscler Thromb Vasc Biol. 2010. PMID: 20042709
Soluble endoglin contributes to the pathogenesis of preeclampsia.
Venkatesha S, Toporsian M, Lam C, Hanai J, Mammoto T, Kim YM, Bdolah Y, Lim KH, Yuan HT, Libermann TA, Stillman IE, Roberts D, D'Amore PA, Epstein FH, Sellke FW, Romero R, Sukhatme VP, Letarte M, Karumanchi SA. Venkatesha S, et al. Among authors: toporsian m. Nat Med. 2006 Jun;12(6):642-9. doi: 10.1038/nm1429. Epub 2006 Jun 4. Nat Med. 2006. PMID: 16751767
Reduced angiogenic responses in adult Endoglin heterozygous mice.
Jerkic M, Rodríguez-Barbero A, Prieto M, Toporsian M, Pericacho M, Rivas-Elena JV, Obreo J, Wang A, Pérez-Barriocanal F, Arévalo M, Bernabéu C, Letarte M, López-Novoa JM. Jerkic M, et al. Among authors: toporsian m. Cardiovasc Res. 2006 Mar 1;69(4):845-54. doi: 10.1016/j.cardiores.2005.11.020. Epub 2006 Jan 10. Cardiovasc Res. 2006. PMID: 16405930 Free article.
15 results