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Targeted delivery of short-chain fatty acids to the human large bowel.
Topping DL. Topping DL. Am J Clin Nutr. 2016 Jul;104(1):1-2. doi: 10.3945/ajcn.116.137711. Epub 2016 Jun 22. Am J Clin Nutr. 2016. PMID: 27334235 No abstract available.
Butyrylated starch increases colonic butyrate concentration but has limited effects on immunity in healthy physically active individuals.
West NP, Christophersen CT, Pyne DB, Cripps AW, Conlon MA, Topping DL, Kang S, McSweeney CS, Fricker PA, Aguirre D, Clarke JM. West NP, et al. Exerc Immunol Rev. 2013;19:102-19. Exerc Immunol Rev. 2013. PMID: 23977723 Clinical Trial.
Butyrylated starch affects colorectal cancer markers beneficially and dose-dependently in genotoxin-treated rats.
Toden S, Lockett TJ, Topping DL, Scherer BL, Watson EJ, Southwood JG, Clarke JM. Toden S, et al. Cancer Biol Ther. 2014;15(11):1515-23. doi: 10.4161/15384047.2014.955764. Cancer Biol Ther. 2014. PMID: 25482948 Free PMC article.
Butyrylated starch intake can prevent red meat-induced O6-methyl-2-deoxyguanosine adducts in human rectal tissue: a randomised clinical trial.
Le Leu RK, Winter JM, Christophersen CT, Young GP, Humphreys KJ, Hu Y, Gratz SW, Miller RB, Topping DL, Bird AR, Conlon MA. Le Leu RK, et al. Br J Nutr. 2015 Jul;114(2):220-30. doi: 10.1017/S0007114515001750. Epub 2015 Jun 17. Br J Nutr. 2015. PMID: 26084032 Free PMC article. Clinical Trial.
Fecal butyrate levels vary widely among individuals but are usually increased by a diet high in resistant starch.
McOrist AL, Miller RB, Bird AR, Keogh JB, Noakes M, Topping DL, Conlon MA. McOrist AL, et al. J Nutr. 2011 May;141(5):883-9. doi: 10.3945/jn.110.128504. Epub 2011 Mar 23. J Nutr. 2011. PMID: 21430242 Clinical Trial.
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