Torphy TJ - Search Results

1

1,4-Cyclohexanecarboxylates: potent and selective inhibitors of phosophodiesterase 4 for the treatment of asthma.

Christensen SB, Guider A, Forster CJ, Gleason JG, Bender PE, Karpinski JM, DeWolf WE Jr, Barnette MS, Underwood DC, Griswold DE, Cieslinski LB, Burman M, Bochnowicz S, Osborn RR, Manning CD, Grous M, Hillegas LM, Bartus JO, Ryan MD, Eggleston DS, Haltiwanger RC, Torphy TJ. Christensen SB, et al. Among authors: torphy tj. J Med Chem. 1998 Mar 12;41(6):821-35. doi: 10.1021/jm970090r. J Med Chem. 1998. PMID: 9526558

2

Coexpression of human cAMP-specific phosphodiesterase activity and high affinity rolipram binding in yeast.

Torphy TJ, Stadel JM, Burman M, Cieslinski LB, McLaughlin MM, White JR, Livi GP. Torphy TJ, et al. J Biol Chem. 1992 Jan 25;267(3):1798-804. J Biol Chem. 1992. PMID: 1309798 Free article.

3

Salbutamol up-regulates PDE4 activity and induces a heterologous desensitization of U937 cells to prostaglandin E2. Implications for the therapeutic use of beta-adrenoceptor agonists.

Torphy TJ, Zhou HL, Foley JJ, Sarau HM, Manning CD, Barnette MS. Torphy TJ, et al. J Biol Chem. 1995 Oct 6;270(40):23598-604. doi: 10.1074/jbc.270.40.23598. J Biol Chem. 1995. PMID: 7559525 Free article.

4

Phosphodiesterase IV inhibitors as therapy for eosinophil-induced lung injury in asthma.

Torphy TJ, Barnette MS, Hay DW, Underwood DC. Torphy TJ, et al. Environ Health Perspect. 1994 Dec;102 Suppl 10(Suppl 10):79-84. doi: 10.1289/ehp.94102s1079. Environ Health Perspect. 1994. PMID: 7705312 Free PMC article.

5

The ability of phosphodiesterase IV inhibitors to suppress superoxide production in guinea pig eosinophils is correlated with inhibition of phosphodiesterase IV catalytic activity.

Barnette MS, Manning CD, Cieslinski LB, Burman M, Christensen SB, Torphy TJ. Barnette MS, et al. Among authors: torphy tj. J Pharmacol Exp Ther. 1995 May;273(2):674-9. J Pharmacol Exp Ther. 1995. PMID: 7752069

6

Inhibitors of phosphodiesterase IV (PDE IV) increase acid secretion in rabbit isolated gastric glands: correlation between function and interaction with a high-affinity rolipram binding site.

Barnette MS, Grous M, Cieslinski LB, Burman M, Christensen SB, Torphy TJ. Barnette MS, et al. Among authors: torphy tj. J Pharmacol Exp Ther. 1995 Jun;273(3):1396-402. J Pharmacol Exp Ther. 1995. PMID: 7791113

7

The crystal structure, absolute configuration, and phosphodiesterase inhibitory activity of (+)-1-(4-bromobenzyl)-4-(3-(cyclopentyloxy)- 4-methoxyphenyl)-pyrrolidin-2-one.

Baures PW, Eggleston DS, Erhard KF, Cieslinski LB, Torphy TJ, Christensen SB. Baures PW, et al. Among authors: torphy tj. J Med Chem. 1993 Oct 29;36(22):3274-7. doi: 10.1021/jm00074a007. J Med Chem. 1993. PMID: 8230117

8

A low-Km, rolipram-sensitive, cAMP-specific phosphodiesterase from human brain. Cloning and expression of cDNA, biochemical characterization of recombinant protein, and tissue distribution of mRNA.

McLaughlin MM, Cieslinski LB, Burman M, Torphy TJ, Livi GP. McLaughlin MM, et al. Among authors: torphy tj. J Biol Chem. 1993 Mar 25;268(9):6470-6. J Biol Chem. 1993. PMID: 8384210 Free article.

9

Association of the anti-inflammatory activity of phosphodiesterase 4 (PDE4) inhibitors with either inhibition of PDE4 catalytic activity or competition for [3H]rolipram binding.

Barnette MS, Bartus JO, Burman M, Christensen SB, Cieslinski LB, Esser KM, Prabhakar US, Rush JA, Torphy TJ. Barnette MS, et al. Among authors: torphy tj. Biochem Pharmacol. 1996 Apr 12;51(7):949-56. doi: 10.1016/0006-2952(96)00053-6. Biochem Pharmacol. 1996. PMID: 8651945

10

SB 207499 (Ariflo), a potent and selective second-generation phosphodiesterase 4 inhibitor: in vitro anti-inflammatory actions.

Barnette MS, Christensen SB, Essayan DM, Grous M, Prabhakar U, Rush JA, Kagey-Sobotka A, Torphy TJ. Barnette MS, et al. Among authors: torphy tj. J Pharmacol Exp Ther. 1998 Jan;284(1):420-6. J Pharmacol Exp Ther. 1998. PMID: 9435206

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