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An immunoaffinity liquid chromatography-tandem mass spectrometry assay for detection of endogenous aggrecan fragments in biological fluids: Use as a biomarker for aggrecanase activity and cartilage degradation.
Dufield DR, Nemirovskiy OV, Jennings MG, Tortorella MD, Malfait AM, Mathews WR. Dufield DR, et al. Among authors: tortorella md. Anal Biochem. 2010 Nov 15;406(2):113-23. doi: 10.1016/j.ab.2010.06.044. Epub 2010 Jul 23. Anal Biochem. 2010. PMID: 20603097
ADAMTS-4 (aggrecanase-1): N-terminal activation mechanisms.
Tortorella MD, Arner EC, Hills R, Gormley J, Fok K, Pegg L, Munie G, Malfait AM. Tortorella MD, et al. Arch Biochem Biophys. 2005 Dec 1;444(1):34-44. doi: 10.1016/j.abb.2005.09.018. Epub 2005 Oct 26. Arch Biochem Biophys. 2005. PMID: 16289022
Aggrecan protects cartilage collagen from proteolytic cleavage.
Pratta MA, Yao W, Decicco C, Tortorella MD, Liu RQ, Copeland RA, Magolda R, Newton RC, Trzaskos JM, Arner EC. Pratta MA, et al. Among authors: tortorella md. J Biol Chem. 2003 Nov 14;278(46):45539-45. doi: 10.1074/jbc.M303737200. Epub 2003 Jul 30. J Biol Chem. 2003. PMID: 12890681
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