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An immunoaffinity liquid chromatography-tandem mass spectrometry assay for detection of endogenous aggrecan fragments in biological fluids: Use as a biomarker for aggrecanase activity and cartilage degradation.
Dufield DR, Nemirovskiy OV, Jennings MG, Tortorella MD, Malfait AM, Mathews WR. Dufield DR, et al. Among authors: tortorella md. Anal Biochem. 2010 Nov 15;406(2):113-23. doi: 10.1016/j.ab.2010.06.044. Epub 2010 Jul 23. Anal Biochem. 2010. PMID: 20603097
Identification of an ADAMTS-4 cleavage motif using phage display leads to the development of fluorogenic peptide substrates and reveals matrilin-3 as a novel substrate.
Hills R, Mazzarella R, Fok K, Liu M, Nemirovskiy O, Leone J, Zack MD, Arner EC, Viswanathan M, Abujoub A, Muruganandam A, Sexton DJ, Bassill GJ, Sato AK, Malfait AM, Tortorella MD. Hills R, et al. Among authors: tortorella md. J Biol Chem. 2007 Apr 13;282(15):11101-9. doi: 10.1074/jbc.M611588200. Epub 2007 Feb 20. J Biol Chem. 2007. PMID: 17311924 Free article.
ADAMTS-4 (aggrecanase-1): N-terminal activation mechanisms.
Tortorella MD, Arner EC, Hills R, Gormley J, Fok K, Pegg L, Munie G, Malfait AM. Tortorella MD, et al. Arch Biochem Biophys. 2005 Dec 1;444(1):34-44. doi: 10.1016/j.abb.2005.09.018. Epub 2005 Oct 26. Arch Biochem Biophys. 2005. PMID: 16289022
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