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Discovery of Cyclic Boronic Acid QPX7728, an Ultrabroad-Spectrum Inhibitor of Serine and Metallo-β-lactamases.
Hecker SJ, Reddy KR, Lomovskaya O, Griffith DC, Rubio-Aparicio D, Nelson K, Tsivkovski R, Sun D, Sabet M, Tarazi Z, Parkinson J, Totrov M, Boyer SH, Glinka TW, Pemberton OA, Chen Y, Dudley MN. Hecker SJ, et al. Among authors: totrov m. J Med Chem. 2020 Jul 23;63(14):7491-7507. doi: 10.1021/acs.jmedchem.9b01976. Epub 2020 Apr 2. J Med Chem. 2020. PMID: 32150407
Vacuuming the periplasm.
Lomovskaya O, Totrov M. Lomovskaya O, et al. Among authors: totrov m. J Bacteriol. 2005 Mar;187(6):1879-83. doi: 10.1128/JB.187.6.1879-1883.2005. J Bacteriol. 2005. PMID: 15743933 Free PMC article. Review. No abstract available.
3-Oxoisoxazole-2(3H)-carboxamides and isoxazol-3-yl carbamates: Resistance-breaking acetylcholinesterase inhibitors targeting the malaria mosquito, Anopheles gambiae.
Verma A, Wong DM, Islam R, Tong F, Ghavami M, Mutunga JM, Slebodnick C, Li J, Viayna E, Lam PC, Totrov MM, Bloomquist JR, Carlier PR. Verma A, et al. Among authors: totrov mm. Bioorg Med Chem. 2015 Mar 15;23(6):1321-40. doi: 10.1016/j.bmc.2015.01.026. Epub 2015 Jan 22. Bioorg Med Chem. 2015. PMID: 25684426 Free PMC article.
Discovery of a Cyclic Boronic Acid β-Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases.
Hecker SJ, Reddy KR, Totrov M, Hirst GC, Lomovskaya O, Griffith DC, King P, Tsivkovski R, Sun D, Sabet M, Tarazi Z, Clifton MC, Atkins K, Raymond A, Potts KT, Abendroth J, Boyer SH, Loutit JS, Morgan EE, Durso S, Dudley MN. Hecker SJ, et al. Among authors: totrov m. J Med Chem. 2015 May 14;58(9):3682-92. doi: 10.1021/acs.jmedchem.5b00127. Epub 2015 Mar 17. J Med Chem. 2015. PMID: 25782055
Difluoromethyl ketones: Potent inhibitors of wild type and carbamate-insensitive G119S mutant Anopheles gambiae acetylcholinesterase.
Camerino E, Wong DM, Tong F, Körber F, Gross AD, Islam R, Viayna E, Mutunga JM, Li J, Totrov MM, Bloomquist JR, Carlier PR. Camerino E, et al. Among authors: totrov mm. Bioorg Med Chem Lett. 2015 Oct 15;25(20):4405-11. doi: 10.1016/j.bmcl.2015.09.019. Epub 2015 Sep 8. Bioorg Med Chem Lett. 2015. PMID: 26386602 Free PMC article.
Spectrum of Beta-Lactamase Inhibition by the Cyclic Boronate QPX7728, an Ultrabroad-Spectrum Beta-Lactamase Inhibitor of Serine and Metallo-Beta-Lactamases: Enhancement of Activity of Multiple Antibiotics against Isogenic Strains Expressing Single Beta-Lactamases.
Lomovskaya O, Tsivkovski R, Nelson K, Rubio-Aparicio D, Sun D, Totrov M, Dudley MN. Lomovskaya O, et al. Among authors: totrov m. Antimicrob Agents Chemother. 2020 May 21;64(6):e00212-20. doi: 10.1128/AAC.00212-20. Print 2020 May 21. Antimicrob Agents Chemother. 2020. PMID: 32229489 Free PMC article.
In Vitro Activity of the Ultra-Broad-Spectrum Beta-Lactamase Inhibitor QPX7728 in Combination with Meropenem against Clinical Isolates of Carbapenem-Resistant Acinetobacter baumannii.
Nelson K, Rubio-Aparicio D, Tsivkovski R, Sun D, Totrov M, Dudley M, Lomovskaya O. Nelson K, et al. Among authors: totrov m. Antimicrob Agents Chemother. 2020 Oct 20;64(11):e01406-20. doi: 10.1128/AAC.01406-20. Print 2020 Oct 20. Antimicrob Agents Chemother. 2020. PMID: 32868334 Free PMC article.
108 results