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Paradoxical (REM) sleep deprivation causes a large and rapidly reversible decrease in long-term potentiation, synaptic transmission, glutamate receptor protein levels, and ERK/MAPK activation in the dorsal hippocampus.
Ravassard P, Pachoud B, Comte JC, Mejia-Perez C, Scoté-Blachon C, Gay N, Claustrat B, Touret M, Luppi PH, Salin PA. Ravassard P, et al. Among authors: touret m. Sleep. 2009 Feb;32(2):227-40. doi: 10.1093/sleep/32.2.227. Sleep. 2009. PMID: 19238810 Free PMC article.
COB231 targets amyloid plaques in post-mortem human brain tissue and in an Alzheimer mouse model.
Garin D, Virgone-Carlotta A, Gözel B, Oukhatar F, Perret P, Marti-Battle D, Touret M, Millet P, Dubois-Dauphin M, Meyronet D, Streichenberger N, Laferla FM, Demeunynck M, Chierici S, Sallanon Moulin M, Ghezzi C. Garin D, et al. Among authors: touret m. J Neurochem. 2015 Mar;132(5):609-18. doi: 10.1111/jnc.12951. J Neurochem. 2015. PMID: 25258048 Free article.
52 results