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IL-36 in psoriasis.
Towne JE, Sims JE. Towne JE, et al. Curr Opin Pharmacol. 2012 Aug;12(4):486-90. doi: 10.1016/j.coph.2012.02.009. Epub 2012 Mar 5. Curr Opin Pharmacol. 2012. PMID: 22398321 Review.
Preclinical development of AMG 139, a human antibody specifically targeting IL-23.
Köck K, Pan WJ, Gow JM, Horner MJ, Gibbs JP, Colbert A, Goletz TJ, Newhall KJ, Rees WA, Sun Y, Zhang Y, O'Neill JC, Umble-Romero AN, Prokop SP, Krill CD, Som L, Buntich SA, Trimble MW, Tsuji WH, Towne JE. Köck K, et al. Among authors: towne je. Br J Pharmacol. 2015 Jan;172(1):159-72. doi: 10.1111/bph.12904. Epub 2014 Dec 15. Br J Pharmacol. 2015. PMID: 25205227 Free PMC article.
Are Th17 cells in the gut pathogenic or protective?
Symons A, Budelsky AL, Towne JE. Symons A, et al. Among authors: towne je. Mucosal Immunol. 2012 Jan;5(1):4-6. doi: 10.1038/mi.2011.51. Epub 2011 Nov 9. Mucosal Immunol. 2012. PMID: 22071661
Mutation in IL36RN impairs the processing and regulatory function of the interleukin-36-receptor antagonist and is associated with DITRA syndrome.
Bal E, Lim AC, Shen M, Douangpanya J, Madrange M, Gazah R, Tauber M, Beghdadi W, Casanova JL, Bourrat E, Bachelez H, Towne JE, Smahi A. Bal E, et al. Among authors: towne je. Exp Dermatol. 2019 Oct;28(10):1114-1117. doi: 10.1111/exd.13387. Epub 2017 Oct 26. Exp Dermatol. 2019. PMID: 28603914
Interleukin-36-receptor antagonist deficiency and generalized pustular psoriasis.
Marrakchi S, Guigue P, Renshaw BR, Puel A, Pei XY, Fraitag S, Zribi J, Bal E, Cluzeau C, Chrabieh M, Towne JE, Douangpanya J, Pons C, Mansour S, Serre V, Makni H, Mahfoudh N, Fakhfakh F, Bodemer C, Feingold J, Hadj-Rabia S, Favre M, Genin E, Sahbatou M, Munnich A, Casanova JL, Sims JE, Turki H, Bachelez H, Smahi A. Marrakchi S, et al. Among authors: towne je. N Engl J Med. 2011 Aug 18;365(7):620-8. doi: 10.1056/NEJMoa1013068. N Engl J Med. 2011. PMID: 21848462
The IL-23/T17 pathogenic axis in psoriasis is amplified by keratinocyte responses.
Lowes MA, Russell CB, Martin DA, Towne JE, Krueger JG. Lowes MA, et al. Among authors: towne je. Trends Immunol. 2013 Apr;34(4):174-81. doi: 10.1016/j.it.2012.11.005. Epub 2013 Jan 3. Trends Immunol. 2013. PMID: 23291100 Free PMC article. Review.
Differential Roles for Interleukin-23 and Interleukin-17 in Intestinal Immunoregulation.
Maxwell JR, Zhang Y, Brown WA, Smith CL, Byrne FR, Fiorino M, Stevens E, Bigler J, Davis JA, Rottman JB, Budelsky AL, Symons A, Towne JE. Maxwell JR, et al. Among authors: towne je. Immunity. 2015 Oct 20;43(4):739-50. doi: 10.1016/j.immuni.2015.08.019. Epub 2015 Sep 29. Immunity. 2015. PMID: 26431947
Regulation and function of interleukin-36 cytokines in homeostasis and pathological conditions.
Gabay C, Towne JE. Gabay C, et al. Among authors: towne je. J Leukoc Biol. 2015 Apr;97(4):645-52. doi: 10.1189/jlb.3RI1014-495R. Epub 2015 Feb 11. J Leukoc Biol. 2015. PMID: 25673295 Review.
The emerging role of IL-17 in the pathogenesis of psoriasis: preclinical and clinical findings.
Martin DA, Towne JE, Kricorian G, Klekotka P, Gudjonsson JE, Krueger JG, Russell CB. Martin DA, et al. Among authors: towne je. J Invest Dermatol. 2013 Jan;133(1):17-26. doi: 10.1038/jid.2012.194. Epub 2012 Jun 7. J Invest Dermatol. 2013. PMID: 22673731 Free PMC article. Review.
Interleukin-36 (IL-36) ligands require processing for full agonist (IL-36α, IL-36β, and IL-36γ) or antagonist (IL-36Ra) activity.
Towne JE, Renshaw BR, Douangpanya J, Lipsky BP, Shen M, Gabel CA, Sims JE. Towne JE, et al. J Biol Chem. 2011 Dec 9;286(49):42594-602. doi: 10.1074/jbc.M111.267922. Epub 2011 Sep 29. J Biol Chem. 2011. PMID: 21965679 Free PMC article.
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