Townsend L - Search Results

1

Distribution and inhibition of dihydrouracil dehydrogenase activities in human tissues using 5-fluorouracil as a substrate.

Ho DH, Townsend L, Luna MA, Bodey GP. Ho DH, et al. Among authors: townsend l. Anticancer Res. 1986 Jul-Aug;6(4):781-4. Anticancer Res. 1986. PMID: 3752956

2

Cytotoxicity of a new uridine analog, 4-hydroxy-1-(beta-D-ribofuranosyl)-pyridazine-6-one, and its interaction with uridine kinase.

Bloomer LC, Wotring LL, Townsend LB. Bloomer LC, et al. Among authors: townsend lb. Cancer Res. 1982 Jan;42(1):100-6. Cancer Res. 1982. PMID: 6172193

3

Mechanism of activation of triciribine phosphate (TCN-P) as a prodrug form of TCN.

Wotring LL, Crabtree GW, Edwards NL, Parks RE Jr, Townsend LB. Wotring LL, et al. Among authors: townsend lb. Cancer Treat Rep. 1986 Apr;70(4):491-7. Cancer Treat Rep. 1986. PMID: 3698043

The tricyclic nucleotide triciribine phosphate (TCN-P) was synthesized as a water-soluble derivative of the tricyclic nucleoside TCN (L. B. Townsend et al, INSERM 81:37, 1978). Growth of L1210 cells in vitro was inhibited equally by TCN and TCN-P. ...

The tricyclic nucleotide triciribine phosphate (TCN-P) was synthesized as a water-soluble derivative of the tricyclic nucleoside TCN (L …

4

Effects of the tricyclic nucleoside 6-amino-4-methyl-8-(beta-D-ribofuranosyl)- pyrrolo[4,3,2-de]pyrimido[4,5-c]pyridazine on the viability and cell cycle distribution of L1210 cells in vitro.

Wotring LL, Passiatore JE, Roti Roti JL, Hudson JL, Townsend LB. Wotring LL, et al. Among authors: townsend lb. Cancer Res. 1985 Dec;45(12 Pt 1):6355-61. Cancer Res. 1985. PMID: 4063986

5

Potentiation of 2'-deoxyguanosine cytotoxicity by a novel inhibitor of purine nucleoside phosphorylase, 8-amino-9-benzylguanine.

Shewach DS, Chern JW, Pillote KE, Townsend LB, Daddona PE. Shewach DS, et al. Among authors: townsend lb. Cancer Res. 1986 Feb;46(2):519-23. Cancer Res. 1986. PMID: 3079664

6

Phase I study of ftorafur, an analog of 5-fluorouracil.

Smart CR, Townsend LB, Rusho WJ, Eyre HJ, Quagliana JM, Wilson ML, Edwards CB, Manning SJ. Smart CR, et al. Among authors: townsend lb. Cancer. 1975 Jul;36(1):103-6. doi: 10.1002/1097-0142(197507)36:1<103::aid-cncr2820360106>3.0.co;2-k. Cancer. 1975. PMID: 1203838

7

Synthesis of pyridazine analogues of the naturally occurring nucleosides cytidine, uridine, deoxycytidine, and deoxyuridine.

Katz DJ, Wise DS, Townsend LB. Katz DJ, et al. Among authors: townsend lb. J Med Chem. 1982 Jul;25(7):813-21. doi: 10.1021/jm00349a009. J Med Chem. 1982. PMID: 7108897

8

Synthesis and biological activity of a novel adenosine analogue, 3-beta-D-ribofuranosylthieno[2,3-d]pyrimidin-4-one.

Patil VD, Wise DS, Wotring LL, Bloomer LC, Townsend LB. Patil VD, et al. Among authors: townsend lb. J Med Chem. 1985 Apr;28(4):423-7. doi: 10.1021/jm00382a006. J Med Chem. 1985. PMID: 3981534

9

Design, synthesis and antiviral activity of novel 4,5-disubstituted 7-(beta-D-ribofuranosyl)pyrrolo[2,3-d][1,2,3]triazines and the novel 3-amino-5-methyl-1-(beta-D-ribofuranosyl)- and 3-amino-5-methyl-1-(2-deoxy-beta-D-ribofuranosyl)-1,5-dihydro-1,4,5,6,7,8-hexaazaacenaphthylene as analogues of triciribine.

Migawa MT, Drach JC, Townsend LB. Migawa MT, et al. J Med Chem. 2005 Jun 2;48(11):3840-51. doi: 10.1021/jm0402014. J Med Chem. 2005. PMID: 15916436

10

Synthesis, antiviral activity, and mode of action of some 3-substituted 2,5,6-trichloroindole 2'- and 5'-deoxyribonucleosides.

Williams JD, Ptak RG, Drach JC, Townsend LB. Williams JD, et al. J Med Chem. 2004 Nov 4;47(23):5773-82. doi: 10.1021/jm0400606. J Med Chem. 2004. PMID: 15509176

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