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The tumor suppressor gene product APC is hyperphosphorylated during the M phase.
Bhattacharjee RN, Hamada F, Toyoshima K, Akiyama T. Bhattacharjee RN, et al. Biochem Biophys Res Commun. 1996 Mar 7;220(1):192-5. doi: 10.1006/bbrc.1996.0379. Biochem Biophys Res Commun. 1996. PMID: 8602842
Identification and characterization of E-APC, a novel Drosophila homologue of the tumour suppressor APC.
Hamada F, Murata Y, Nishida A, Fujita F, Tomoyasu Y, Nakamura M, Toyoshima K, Tabata T, Ueno N, Akiyama T. Hamada F, et al. Genes Cells. 1999 Aug;4(8):465-74. doi: 10.1046/j.1365-2443.1999.00272.x. Genes Cells. 1999. PMID: 10526234
Negative regulation of Wingless signaling by D-axin, a Drosophila homolog of axin.
Hamada F, Tomoyasu Y, Takatsu Y, Nakamura M, Nagai S, Suzuki A, Fujita F, Shibuya H, Toyoshima K, Ueno N, Akiyama T. Hamada F, et al. Science. 1999 Mar 12;283(5408):1739-42. doi: 10.1126/science.283.5408.1739. Science. 1999. PMID: 10073940
The tumor suppressor protein APC colocalizes with beta-catenin in the colon epithelial cells.
Senda T, Miyashiro I, Matsumine A, Baeg GH, Monden T, Kobayashil S, Monden M, Toyoshima K, Akiyama T. Senda T, et al. Biochem Biophys Res Commun. 1996 Jun 14;223(2):329-34. doi: 10.1006/bbrc.1996.0894. Biochem Biophys Res Commun. 1996. PMID: 8670282
K-ras is essential for the development of the mouse embryo.
Koera K, Nakamura K, Nakao K, Miyoshi J, Toyoshima K, Hatta T, Otani H, Aiba A, Katsuki M. Koera K, et al. Oncogene. 1997 Sep 4;15(10):1151-9. doi: 10.1038/sj.onc.1201284. Oncogene. 1997. PMID: 9294608
To clarify the role of the K-Ras in vivo, we generated K-ras mutant mice by gene targeting. In contrast to the findings that H-Ras-deficient mice and N-Ras-deficient mice are born and grow normally, the K-Ras-deficient embryos die progressively between embryo …
To clarify the role of the K-Ras in vivo, we generated K-ras mutant mice by gene targeting. In contrast to the findings that H …
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