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Metabolic effects of cachectin/tumor necrosis factor are modified by site of production. Cachectin/tumor necrosis factor-secreting tumor in skeletal muscle induces chronic cachexia, while implantation in brain induces predominantly acute anorexia.
Tracey KJ, Morgello S, Koplin B, Fahey TJ 3rd, Fox J, Aledo A, Manogue KR, Cerami A. Tracey KJ, et al. J Clin Invest. 1990 Dec;86(6):2014-24. doi: 10.1172/JCI114937. J Clin Invest. 1990. PMID: 2254457 Free PMC article.
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