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Mechanism-based inactivation of P450 2A6 by furanocoumarins.
Koenigs LL, Trager WF. Koenigs LL, et al. Among authors: trager wf. Biochemistry. 1998 Jul 14;37(28):10047-61. doi: 10.1021/bi980003c. Biochemistry. 1998. PMID: 9665710
Enzymatic degradation of heme. Oxygenative cleavage requiring cytochrome P-450.
Tenhunen R, Marver H, Pimstone NR, Trager WF, Cooper DY, Schmid R. Tenhunen R, et al. Among authors: trager wf. Biochemistry. 1972 Apr 25;11(9):1716-20. doi: 10.1021/bi00759a029. Biochemistry. 1972. PMID: 4402159 No abstract available.
Studies on the mechanism of aromatase and other cytochrome P450 mediated deformylation reactions.
Korzekwa KR, Trager WF, Mancewicz J, Osawa Y. Korzekwa KR, et al. Among authors: trager wf. J Steroid Biochem Mol Biol. 1993 Mar;44(4-6):367-73. doi: 10.1016/0960-0760(93)90240-w. J Steroid Biochem Mol Biol. 1993. PMID: 8476750 Review.
Isotopically labeled chlorobenzenes as probes for the mechanism of cytochrome P-450 catalyzed aromatic hydroxylation.
Korzekwa KR, Swinney DC, Trager WF. Korzekwa KR, et al. Among authors: trager wf. Biochemistry. 1989 Nov 14;28(23):9019-27. doi: 10.1021/bi00449a010. Biochemistry. 1989. PMID: 2605239
Theory for the observed isotope effects from enzymatic systems that form multiple products via branched reaction pathways: cytochrome P-450.
Korzekwa KR, Trager WF, Gillette JR. Korzekwa KR, et al. Among authors: trager wf. Biochemistry. 1989 Nov 14;28(23):9012-8. doi: 10.1021/bi00449a009. Biochemistry. 1989. PMID: 2605238
The mechanism of the warfarin-rifampin drug interaction in humans.
Heimark LD, Gibaldi M, Trager WF, O'Reilly RA, Goulart DA. Heimark LD, et al. Among authors: trager wf. Clin Pharmacol Ther. 1987 Oct;42(4):388-94. doi: 10.1038/clpt.1987.168. Clin Pharmacol Ther. 1987. PMID: 3665337
The use of deuterium isotope effects to probe the active site properties, mechanism of cytochrome P450-catalyzed reactions, and mechanisms of metabolically dependent toxicity.
Nelson SD, Trager WF. Nelson SD, et al. Among authors: trager wf. Drug Metab Dispos. 2003 Dec;31(12):1481-98. doi: 10.1124/dmd.31.12.1481. Drug Metab Dispos. 2003. PMID: 14625345 Review.
(+)-N-3-Benzyl-nirvanol and (-)-N-3-benzyl-phenobarbital: new potent and selective in vitro inhibitors of CYP2C19.
Suzuki H, Kneller MB, Haining RL, Trager WF, Rettie AE. Suzuki H, et al. Among authors: trager wf. Drug Metab Dispos. 2002 Mar;30(3):235-9. doi: 10.1124/dmd.30.3.235. Drug Metab Dispos. 2002. PMID: 11854139
Characterization of covalent adducts to intact cytochrome P450s by mass spectrometry.
Lightning LK, Trager WF. Lightning LK, et al. Among authors: trager wf. Methods Enzymol. 2002;357:296-300. doi: 10.1016/s0076-6879(02)57687-4. Methods Enzymol. 2002. PMID: 12424919 No abstract available.
Photoaffinity labeling of P450Cam by an imidazole-tethered benzophenone probe.
Trnka MJ, Doneanu CE, Trager WF. Trnka MJ, et al. Among authors: trager wf. Arch Biochem Biophys. 2006 Jan 1;445(1):95-107. doi: 10.1016/j.abb.2005.10.014. Epub 2005 Nov 14. Arch Biochem Biophys. 2006. PMID: 16321358
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