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A randomized, controlled trial of a multi-modal exercise intervention in Huntington's disease.
Quinn L, Hamana K, Kelson M, Dawes H, Collett J, Townson J, Roos R, van der Plas AA, Reilmann R, Frich JC, Rickards H, Rosser A, Busse M. Quinn L, et al. Among authors: Busse M. Parkinsonism Relat Disord. 2016 Oct;31:46-52. doi: 10.1016/j.parkreldis.2016.06.023. Epub 2016 Jul 1. Parkinsonism Relat Disord. 2016. PMID: 27423921 Free article. Clinical Trial.
INTRODUCTION: This study aimed to evaluate the feasibility and benefit of a structured exercise intervention in people with Huntington's Disease (HD). ...Individuals with HD may benefit from structured exercise, and intensity, monitoring and support may be ke …
INTRODUCTION: This study aimed to evaluate the feasibility and benefit of a structured exercise intervention in people with Huntington's
Rehabilitation training in neural restitution.
Clinch S, Busse M, Döbrössy MD, Dunnett SB. Clinch S, et al. Among authors: Busse M. Prog Brain Res. 2017;230:305-329. doi: 10.1016/bs.pbr.2016.12.006. Epub 2017 Mar 7. Prog Brain Res. 2017. PMID: 28552234
Preclinical studies in rat lesion models of Huntington's disease (HD) and Parkinson's disease (PD) have shown that transplanted precursor neuronal tissue from a fetus into the lesioned striatum can survive, integrate, and reconnect circuitry. ...Clinical tran …
Preclinical studies in rat lesion models of Huntington's disease (HD) and Parkinson's disease (PD) have shown that tran …
The role of rehabilitation therapy in Huntington disease.
Quinn L, Busse M. Quinn L, et al. Among authors: Busse M. Handb Clin Neurol. 2017;144:151-165. doi: 10.1016/B978-0-12-801893-4.00013-4. Handb Clin Neurol. 2017. PMID: 28947114 Review.
The role of rehabilitation interventions is increasingly considered a key component to effective management of people with Huntington disease (HD). Lifestyle factors, such as activity level and exercise, as well as specific motor training may be helpful in managing …
The role of rehabilitation interventions is increasingly considered a key component to effective management of people with Huntington diseas …
A Classification System to Guide Physical Therapy Management in Huntington Disease: A Case Series.
Fritz NE, Busse M, Jones K, Khalil H, Quinn L; Members of the Physiotherapy Working Group of the European Huntingtonʼs Disease Network. Fritz NE, et al. Among authors: Busse M. J Neurol Phys Ther. 2017 Jul;41(3):156-163. doi: 10.1097/NPT.0000000000000188. J Neurol Phys Ther. 2017. PMID: 28628549
The purpose of this case series was to illustrate the use of these classifications in the management of 2 individuals with late-stage HD. ...INTERVENTION: Physical therapy Treatment-Based Classifications for HD guided the interventions and outcomes. Eight weeks of i …
The purpose of this case series was to illustrate the use of these classifications in the management of 2 individuals with late-stage HD
Exploring computerised cognitive training as a therapeutic intervention for people with Huntington's disease (CogTrainHD): protocol for a randomised feasibility study.
Yhnell E, Furby H, Breen RS, Brookes-Howell LC, Drew CJG, Playle R, Watson G, Metzler-Baddeley C, Rosser AE, Busse ME. Yhnell E, et al. Among authors: Busse ME. Pilot Feasibility Stud. 2018 Feb 6;4:45. doi: 10.1186/s40814-018-0237-0. eCollection 2018. Pilot Feasibility Stud. 2018. PMID: 29445514 Free PMC article.
BACKGROUND: Cognitive impairments, especially deficits of executive function, have been well documented as a core and early feature in Huntington's disease (HD). ...DISCUSSION: The results of this study will provide crucial guidance and information regarding the fea …
BACKGROUND: Cognitive impairments, especially deficits of executive function, have been well documented as a core and early feature in Hunti …
Physical Activity Self-Management and Coaching Compared to Social Interaction in Huntington Disease: Results From the ENGAGE-HD Randomized, Controlled Pilot Feasibility Trial.
Busse M, Quinn L, Drew C, Kelson M, Trubey R, McEwan K, Jones C, Townson J, Dawes H, Tudor-Edwards R, Rosser A, Hood K. Busse M, et al. Phys Ther. 2017 Jun 1;97(6):625-639. doi: 10.1093/ptj/pzx031. Phys Ther. 2017. PMID: 28371942 Free PMC article. Clinical Trial.
SETTING: Participants were recruited and assessed at baseline, 16 weeks following randomization, and then again at 26 weeks in HD specialist clinics with intervention delivery by trained coaches in the participants' homes. PATIENTS AND INTERVENTION: People with H
SETTING: Participants were recruited and assessed at baseline, 16 weeks following randomization, and then again at 26 weeks in HD spe …
Exercise testing and training in people with Huntington's disease.
Dawes H, Collett J, Debono K, Quinn L, Jones K, Kelson MJ, Simpson SA, Playle R, Backx K, Wasley D, Nemeth AH, Rosser A, Izardi H, Busse M. Dawes H, et al. Among authors: Busse M. Clin Rehabil. 2015 Feb;29(2):196-206. doi: 10.1177/0269215514540921. Epub 2014 Aug 20. Clin Rehabil. 2015. PMID: 25142278 Clinical Trial.
OBJECTIVE: To explore exercise response in people with Huntington's disease (HD). DESIGN: Experimental observational study with a randomly allocated subgroup before/after interventional study. ...SUBJECTS: People with HD (n=30) and a healthy comparator group …
OBJECTIVE: To explore exercise response in people with Huntington's disease (HD). DESIGN: Experimental observational study wit …
Neurorehabilitation with neural transplantation.
Döbrössy M, Busse M, Piroth T, Rosser A, Dunnett S, Nikkhah G. Döbrössy M, et al. Among authors: Busse M. Neurorehabil Neural Repair. 2010 Oct;24(8):692-701. doi: 10.1177/1545968310363586. Epub 2010 Jul 20. Neurorehabil Neural Repair. 2010. PMID: 20647502 Review.
Cell replacement therapy has been tested clinically in Parkinson's disease (PD) and Huntington's disease (HD), epilepsy, spinal cord injury, and stroke. ...The growing evidence of plasticity demonstrated by the brain and grafts in response to environmental an …
Cell replacement therapy has been tested clinically in Parkinson's disease (PD) and Huntington's disease (HD), epilepsy …
Development and Delivery of a Physical Activity Intervention for People With Huntington Disease: Facilitating Translation to Clinical Practice.
Quinn L, Trubey R, Gobat N, Dawes H, Edwards RT, Jones C, Townson J, Drew C, Kelson M, Poile V, Rosser A, Hood K, Busse M. Quinn L, et al. Among authors: Busse M. J Neurol Phys Ther. 2016 Apr;40(2):71-80. doi: 10.1097/NPT.0000000000000119. J Neurol Phys Ther. 2016. PMID: 26863152 Free PMC article. Clinical Trial.
Training of coaches (physical therapists, occupational therapists, research nurses, and exercise trainers) was delivered via group and 1:1 training sessions using a detailed coach's manual, and with ongoing support via video calls, and e-mail communication as
Training of coaches (physical therapists, occupational therapists, research nurses, and exercise trainers) was delivered via group an
Practice, progress and future directions for physical therapies in Huntingtons disease.
Busse M, Khalil H, Brooks S, Quinn L, Rosser A. Busse M, et al. J Huntingtons Dis. 2012;1(2):175-85. doi: 10.3233/JHD-120025. J Huntingtons Dis. 2012. PMID: 25063330 Review.
Physical therapies and exercise may have potential as a disease modifying agent in Huntington's disease (HD) and in recent years, there have been several small scale feasibility studies that have shown benefit as a result of physical interventions. ...The majority o …
Physical therapies and exercise may have potential as a disease modifying agent in Huntington's disease (HD) and in recent yea …
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