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Amyloid-PET predicts inhibition of de novo plaque formation upon chronic γ-secretase modulator treatment.
Brendel M, Jaworska A, Herms J, Trambauer J, Rötzer C, Gildehaus FJ, Carlsen J, Cumming P, Bylund J, Luebbers T, Bartenstein P, Steiner H, Haass C, Baumann K, Rominger A. Brendel M, et al. Among authors: trambauer j. Mol Psychiatry. 2015 Oct;20(10):1179-87. doi: 10.1038/mp.2015.74. Epub 2015 Jun 9. Mol Psychiatry. 2015. PMID: 26055427 Free PMC article.
Monitoring of chronic γ-secretase modulator treatment by serial amyloid-PET.
Brendel M, Jaworska A, Herms J, Trambauer J, Rötzer C, Gildehaus FJ, Carlsen J, Cumming P, Bylund J, Luebbers T, Bartenstein P, Steiner H, Haass C, Baumann K, Rominger A. Brendel M, et al. Among authors: trambauer j. Mol Psychiatry. 2015 Oct;20(10):1141. doi: 10.1038/mp.2015.146. Mol Psychiatry. 2015. PMID: 26401838 No abstract available.
Generation and deposition of Aβ43 by the virtually inactive presenilin-1 L435F mutant contradicts the presenilin loss-of-function hypothesis of Alzheimer's disease.
Kretner B, Trambauer J, Fukumori A, Mielke J, Kuhn PH, Kremmer E, Giese A, Lichtenthaler SF, Haass C, Arzberger T, Steiner H. Kretner B, et al. Among authors: trambauer j. EMBO Mol Med. 2016 May 2;8(5):458-65. doi: 10.15252/emmm.201505952. Print 2016 May. EMBO Mol Med. 2016. PMID: 26988102 Free PMC article.
Identification of a rare presenilin 1 single amino acid deletion mutation (F175del) with unusual amyloid-β processing effects.
Vöglein J, Willem M, Trambauer J, Schönecker S, Dieterich M, Biskup S, Giudici C, Utz K, Oberstein T, Brendel M, Rominger A, Danek A, Steiner H, Haass C, Levin J. Vöglein J, et al. Among authors: trambauer j. Neurobiol Aging. 2019 Dec;84:241.e5-241.e11. doi: 10.1016/j.neurobiolaging.2019.08.034. Epub 2019 Sep 20. Neurobiol Aging. 2019. PMID: 31627977
Modulation of γ-Secretase Activity by a Carborane-Based Flurbiprofen Analogue.
Saretz S, Basset G, Useini L, Laube M, Pietzsch J, Drača D, Maksimović-Ivanić D, Trambauer J, Steiner H, Hey-Hawkins E. Saretz S, et al. Among authors: trambauer j. Molecules. 2021 May 11;26(10):2843. doi: 10.3390/molecules26102843. Molecules. 2021. PMID: 34064783 Free PMC article.