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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1987 1
1988 1
1989 1
1991 1
1992 3
1993 1
1994 1
1995 7
1996 2
1997 2
1998 3
1999 4
2000 13
2001 9
2002 12
2003 15
2004 18
2005 20
2006 25
2007 39
2008 42
2009 53
2010 56
2011 78
2012 82
2013 77
2014 87
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2017 84
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1,347 results

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Page 1
PGC-1alpha-mediated regulation of mitochondrial function and physiological implications.
Halling JF, Pilegaard H. Halling JF, et al. Appl Physiol Nutr Metab. 2020 Sep;45(9):927-936. doi: 10.1139/apnm-2020-0005. Epub 2020 Jun 9. Appl Physiol Nutr Metab. 2020. PMID: 32516539 Review.
This review aims to highlight the current evidence for PGC-1alpha-mediated regulation of skeletal muscle mitochondrial function beyond the effects on mitochondrial biogenesis as well as the potential PGC-1alpha-related impact on insulin-stimulated gluc …
This review aims to highlight the current evidence for PGC-1alpha-mediated regulation of skeletal muscle mitochondrial function …
Quality control of the mitochondrion.
Ng MYW, Wai T, Simonsen A. Ng MYW, et al. Dev Cell. 2021 Apr 5;56(7):881-905. doi: 10.1016/j.devcel.2021.02.009. Epub 2021 Mar 3. Dev Cell. 2021. PMID: 33662258 Free article. Review.
Mitochondria are essential organelles that execute and coordinate various metabolic processes in the cell. Mitochondrial dysfunction severely affects cell fitness and contributes to disease. Proper organellar function depends on the biogenesis and maintenance …
Mitochondria are essential organelles that execute and coordinate various metabolic processes in the cell. Mitochondrial dysfunction …
Transcriptional paradigms in mammalian mitochondrial biogenesis and function.
Scarpulla RC. Scarpulla RC. Physiol Rev. 2008 Apr;88(2):611-38. doi: 10.1152/physrev.00025.2007. Physiol Rev. 2008. PMID: 18391175 Free article. Review.
The transcription factors target genes that specify the respiratory chain, the mitochondrial transcription, translation and replication machinery, and protein import and assembly apparatus among others. These factors are in turn activated directly or indirect …
The transcription factors target genes that specify the respiratory chain, the mitochondrial transcription, translation …
Mitochondrial OXPHOS Biogenesis: Co-Regulation of Protein Synthesis, Import, and Assembly Pathways.
Tang JX, Thompson K, Taylor RW, Oláhová M. Tang JX, et al. Int J Mol Sci. 2020 May 28;21(11):3820. doi: 10.3390/ijms21113820. Int J Mol Sci. 2020. PMID: 32481479 Free PMC article. Review.
The assembly of mitochondrial oxidative phosphorylation (OXPHOS) complexes is an intricate process, which-given their dual-genetic control-requires tight co-regulation of two evolutionarily distinct gene expression machineries. ...In this review, we describe …
The assembly of mitochondrial oxidative phosphorylation (OXPHOS) complexes is an intricate process, which-given their dual-genetic …
Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network.
Scarpulla RC. Scarpulla RC. Biochim Biophys Acta. 2011 Jul;1813(7):1269-78. doi: 10.1016/j.bbamcr.2010.09.019. Epub 2010 Oct 13. Biochim Biophys Acta. 2011. PMID: 20933024 Free PMC article. Review.
The PGC-1 family of regulated coactivators, consisting of PGC-1alpha, PGC-1beta and PRC, plays a central role in a regulatory network governing the transcriptional control of mitochondrial biogenesis and respiratory function. These coactivators …
The PGC-1 family of regulated coactivators, consisting of PGC-1alpha, PGC-1beta and PRC, plays a central role in a regulatory network govern …
Sirt1 and the Mitochondria.
Tang BL. Tang BL. Mol Cells. 2016 Feb;39(2):87-95. doi: 10.14348/molcells.2016.2318. Epub 2016 Feb 2. Mol Cells. 2016. PMID: 26831453 Free PMC article. Review.
Although primarily a nuclear protein, Sirt1's deacetylation of Peroxisome proliferator-activated receptor Gamma Coactivator-1alpha (PGC-1alpha) has been extensively implicated in metabolic control and mitochondrial biogenesis, which was proposed to partially …
Although primarily a nuclear protein, Sirt1's deacetylation of Peroxisome proliferator-activated receptor Gamma Coactivator-1alpha (PGC-1alp …
Replication and Transcription of Human Mitochondrial DNA.
Falkenberg M, Larsson NG, Gustafsson CM. Falkenberg M, et al. Annu Rev Biochem. 2024 Aug;93(1):47-77. doi: 10.1146/annurev-biochem-052621-092014. Epub 2024 Jul 2. Annu Rev Biochem. 2024. PMID: 38594940 Free article. Review.
Single molecules of mtDNA are packaged by mitochondrial transcription factor A into mitochondrial nucleoids, and their level of compaction influences the initiation of both replication and transcription. ...Mechanisms controlling mtDNA replicati …
Single molecules of mtDNA are packaged by mitochondrial transcription factor A into mitochondrial nucleoids, and their …
Transcriptional control of mitochondrial biogenesis and function.
Hock MB, Kralli A. Hock MB, et al. Annu Rev Physiol. 2009;71:177-203. doi: 10.1146/annurev.physiol.010908.163119. Annu Rev Physiol. 2009. PMID: 19575678 Review.
The same transcriptional network senses cues relaying cellular energy status, nutrient availability, and the physiological state of the organism and enables short- and long-term adaptive responses, resulting in adjustments to mitochondrial function and mit …
The same transcriptional network senses cues relaying cellular energy status, nutrient availability, and the physiological state of t …
Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1.
Wu Z, Puigserver P, Andersson U, Zhang C, Adelmant G, Mootha V, Troy A, Cinti S, Lowell B, Scarpulla RC, Spiegelman BM. Wu Z, et al. Cell. 1999 Jul 9;98(1):115-24. doi: 10.1016/S0092-8674(00)80611-X. Cell. 1999. PMID: 10412986 Free article.
PGC-1 stimulates a powerful induction of NRF-1 and NRF-2 gene expression; in addition, PGC-1 binds to and coactivates the transcriptional function of NRF-1 on the promoter for mitochondrial transcription factor A (mtTFA), a direct regulator of mitoc …
PGC-1 stimulates a powerful induction of NRF-1 and NRF-2 gene expression; in addition, PGC-1 binds to and coactivates the transcriptional …
Transcriptional control of mitochondrial biogenesis and its interface with inflammatory processes.
Piantadosi CA, Suliman HB. Piantadosi CA, et al. Biochim Biophys Acta. 2012 Apr;1820(4):532-41. doi: 10.1016/j.bbagen.2012.01.003. Epub 2012 Jan 14. Biochim Biophys Acta. 2012. PMID: 22265687 Free PMC article. Review.
Recent evidence indicates that these cell defenses also include mitochondrial biogenesis and the clearance of damaged mitochondria through autophagy. SCOPE OF REVIEW: This review addresses a group of transcriptional signaling mechanisms that engage mitocho …
Recent evidence indicates that these cell defenses also include mitochondrial biogenesis and the clearance of damaged mitochon …
1,347 results